Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy

Li, Xinsheng; Cao, Qiuchen; Xu, Changlin; Wang, Jinfan; Pan, Ting; Liu, Qinghuai; Xie, Ping; Hu, Zizhong

doi:10.1016/j.exer.2024.109912

Experimental Eye Research

2024

DOI: 10.1016/j.exer.2024.109912

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Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy

Xinsheng Li,

Qiuchen Cao,

Changlin Xu

et al.

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Cited by 4 publications

References 48 publications

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Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

Tang,

Xu,

Zhao

et al. 2025

Clinical Neurology and Neurosurgery

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Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

Tang,

Xu,

Zhao

et al. 2025

Clinical Neurology and Neurosurgery

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Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications

Fang,

Zhang,

Zhang

et al. 2024

J Transl Med

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Diabetic vascular complications attract increased attention due to their high morbidity, mortality and disability rate. Comprehensive and in-depth exploration of the etiology and pathogenesis of diabetic vascular complications is important for diagnosis and treatment. Endothelial extracellular vesicles (EVs) serve as potential intercellular communicators, transmitting biological information from the donor cell to the recipient cell, exerting both harmful and beneficial effects on vascular function. Endothelial EVs are new diagnostic and therapeutic targets and biomarkers in diabetic vascular complications. This review summarizes the biogenesis and release of endothelial EVs, as well as isolation and characterization methods, and discusses the role of endothelial EVs in the maintenance of vascular homeostasis along with their contributions to vascular dysfunction. Finally, the article illustrates the impact of endothelial EVs on the pathogenesis of diabetic vascular complications and evaluates their potential as therapeutic tools and diagnostic markers in diabetic vascular complications.

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Deciphering the role of exosomal derived regulatory noncoding RNAs as potential biomarkers for diabetic retinopathy: a systematic review

Nandalal,

Venkatesan,

Haridoss

et al. 2024

Int J Retin Vitr

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About one-third of individuals with diabetes develop diabetic retinopathy (DR), with one-tenth experiencing vision-threatening conditions such as diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Current treatments only show recovery in 50% of cases, and the disease often remains asymptomatic. Therefore, novel early detection methods and new biomarkers are crucial. Our study aims to summarise evidence on the role of altered exosomal regulatory noncoding RNAs in DR, based on human studies. Observational studies delineating the different exosomal noncoding RNAs in DR were searched systematically from inception to June 2024 in PubMed-MEDLINE and SCOPUS databases. Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines was used to conduct this systematic review (Prospero ID: CRD42023406724). We synthesised data from 13 human studies that assessed the expression of exosomal regulatory ncRNAs from individuals with DR. Among the 13 studies, nine focused on miRNA, while three examined lncRNA and one on circRNA. Although no common genes were identified across the studies, the review underscores the critical roles of exosomal noncoding RNAs in the pathogenesis of diabetic retinopathy, highlighting their potential as therapeutic targets. Future studies should aim for a unified approach in terms of sample selection, RNA analysis, and appropriate controls for a comprehension of exosomal expression patterns for early diagnosis of DR.

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Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy

Cited by 4 publications

References 48 publications

Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications

Deciphering the role of exosomal derived regulatory noncoding RNAs as potential biomarkers for diabetic retinopathy: a systematic review

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