Exosomal lncRNAs in gastrointestinal cancer

Vosough, Parisa; Khatami, Seyyed Hossein; Hashemloo, Ali; Tajbakhsh, Amir; Karimi-Fard, Farzaneh; Taghvimi, Sina; Taheri‐Anganeh, Mortaza; Fard, Elahe Soltani; Savardashtaki, Amir; Movahedpour, Ahmad

doi:10.1016/j.cca.2022.117216

Cited by 8 publications

(4 citation statements)

References 156 publications

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“…Numerous dysregulated lncRNAs have been reported in GC and are involved in tumorigenesis, metastasis, invasion, drug resistance, stem cell progression, and immune escape 20,47,68–73 . LncRNAs are emerging as a new class of promising biomarkers for the diagnosis and prognosis of GC and as therapeutic targets for GC precision medicine 72,74,75 . However, the functions and mechanisms of most lncRNAs remain to be clarified.…”

Section: Discussionmentioning

confidence: 99%

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LINC00355 promotes gastric carcinogenesis by scaffolding p300 to activate CDC42 transcription and enhancing HNRNPA2B1 to stabilize CDC42 mRNA dependent on m6A

Chen,

Xiao,

Xie

et al. 2023

Molecular Carcinogenesis

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LINC00355 is involved in the tumorigenesis of several types of cancer. We verified that LINC00355 is upregulated in gastric cancer (GC) and contributes to GC cells' proliferation and metastasis. RNA sequencing (RNA‐seq) and rescue assays suggested that LINC00355 controls gastric carcinogenesis by regulating the expression of cell division cycle 42 (CDC42) guanosine triphosphatase (GTPases), thereby activating their downstream pathways. Most previous studies have shown that LINC00355 acts as a ceRNA by sponging miRNAs to modulate downstream gene expression. Our group focus on epigenetic regulatory potential of LINC00355 in gene expression. Mechanistically, LINC00355 binds to p300 histone acetyltransferase, specifying the histone modification pattern on the CDC42 promoter to activate CDC42 transcription, thereby altering GC cell biology. In addition, HNRNPA2B1, which is upregulated by LINC00355, recognizes the N6‐methyladenosine (m6A) sites of CDC42 and enhances the stability of CDC42 mRNA transcripts. Therefore, LINC00355 is mechanistically, functionally, and clinically oncogenic in GC cells.

show abstract

Section: Discussionmentioning

confidence: 99%

“…20,47,[68][69][70][71][72][73] and prognosis of GC and as therapeutic targets for GC precision medicine. 72,74,75 However, the functions and mechanisms of most lncRNAs remain to be clarified.…”

Section: Discussionmentioning

confidence: 99%

LINC00355 promotes gastric carcinogenesis by scaffolding p300 to activate CDC42 transcription and enhancing HNRNPA2B1 to stabilize CDC42 mRNA dependent on m6A

Chen,

Xiao,

Xie

et al. 2023

Molecular Carcinogenesis

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“…Exosomal lncRNAs present multiple benefits when considered as biomarkers. Protected from degradation by RNases within exosomes, these lncRNAs remained stable and detectable in various body fluids, making them a potential non-invasive diagnostic tool [ 135 , 140 , 141 , 142 , 143 , 144 ]. Moreover, given the tissue- or disease-specific nature of many lncRNAs, the detection of specific exosomal lncRNAs might indicate distinct cancer types.…”

Section: Lncrnas As Serum Biomarkers In Liver Cancermentioning

confidence: 99%

A New Understanding of Long Non-Coding RNA in Hepatocellular Carcinoma—From m6A Modification to Blood Biomarkers

Eun,

Cheong,

Jeong

et al. 2023

Cells

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With recent advancements in biological research, long non-coding RNAs (lncRNAs) with lengths exceeding 200 nucleotides have emerged as pivotal regulators of gene expression and cellular phenotypic modulation. Despite initial skepticism due to their low sequence conservation and expression levels, their significance in various biological processes has become increasingly apparent. We provided an overview of lncRNAs and discussed their defining features and modes of operation. We then explored their crucial function in the hepatocarcinogenesis process, elucidating their complex involvement in hepatocellular carcinoma (HCC). The influential role of lncRNAs within the HCC tumor microenvironment is emphasized, illustrating their potential as key modulators of disease dynamics. We also investigated the significant influence of N6-methyladenosine (m6A) modification on lncRNA function in HCC, enhancing our understanding of both their roles and their upstream regulators. Additionally, the potential of lncRNAs as promising biomarkers was discussed in liver cancer diagnosis, suggesting a novel avenue for future research and clinical application. Finally, our work underscored the dual potential of lncRNAs as both contributors to HCC pathogenesis and innovative tools for its diagnosis. Existing challenges and prospective trajectories in lncRNA research are also discussed, emphasizing their potential in advancing liver cancer research.

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“…LncRNAs function as competitive endogenous RNAs by competitively occupying the shared binding sequences of miRNAs, thus sequestering the miRNAs and changing the expression of their downstream target genes ( 89 ). Exosomal lncRNAs may also act as biomarkers in the diagnosis of cancers and infectious diseases ( 90 , 91 ). The present review summarizes all lncRNAs related to TB in following studies ( Table 3 ).…”

Section: The Roles Of Other Exosomal Ncrnas In M Tb ...mentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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Tuberculosis (TB) is a major infectious disease induced by Mycobacterium tuberculosis (M. tb) which causes the world’s dominant fatal bacterial contagious disease. Increasing studies have indicated that exosomes may be a novel option for the diagnosis and treatment of TB. Exosomes are nanovesicles (30-150 nm) containing lipids, proteins and non-coding RNAs (ncRNAs) released from various cells, and can transfer their cargos and communicate between cells. Furthermore, exosomal ncRNAs exhibit diagnosis potential in bacterial infections, including TB. Additionally, differential exosomal ncRNAs regulate the physiological and pathological functions of M. tb-infected cells and act as diagnostic markers for TB. This current review explored the potential biological roles and the diagnostic application prospects of exosomal ncRNAs, and included recent information on their pathogenic and therapeutic functions in TB.

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Exosomal lncRNAs in gastrointestinal cancer

Cited by 8 publications

References 156 publications

LINC00355 promotes gastric carcinogenesis by scaffolding p300 to activate CDC42 transcription and enhancing HNRNPA2B1 to stabilize CDC42 mRNA dependent on m6A

LINC00355 promotes gastric carcinogenesis by scaffolding p300 to activate CDC42 transcription and enhancing HNRNPA2B1 to stabilize CDC42 mRNA dependent on m6A

A New Understanding of Long Non-Coding RNA in Hepatocellular Carcinoma—From m6A Modification to Blood Biomarkers

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

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