Exosomal microRNA-133b-3p from bone marrow mesenchymal stem cells inhibits angiogenesis and oxidative stress via FBN1 repression in diabetic retinopathy

Liang, Gaohua; Qin, Zhi-Liang; Luo, Yanni; Yin, Jiayang; Shi, Zhimin; Wei, Rizhang; Ma, Wenhao

doi:10.1038/s41434-021-00310-5

Cited by 21 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The miRNAs described above can commonly inhibit angiogenesis through downregulation of target genes. In fact, miR-205 downregulates VEGA in gastric cancer [ 71 ], hepatocellular carcinoma [ 72 ], and the extracellular vesicles from diabetic ulcers [ 73 ], whereas miR133b in the exosomes secreted from bone marrow mesenchymal stem cells downregulates FBN1 [ 74 ] and miR-27b downregulates AMPK in brain microvascular endothelial cells [ 75 ], CDH5 (a.k.a. VE-cadherin) in ovarian cancer [ 76 ], and VEGFC in gastric cancer [ 77 ].…”

Section: Micrornas Related To Cleft Lipmentioning

confidence: 99%

MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate

Iwaya

Suzuki

Iwata

2023

IJMS

View full text Add to dashboard Cite

Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding questions is how environmental factors lead to craniofacial developmental anomalies. Recent studies highlight non-coding RNAs as potential epigenetic regulators in cleft lip and palate. In this review, we will discuss microRNAs, a type of small non-coding RNAs that can simultaneously regulate expression of many downstream target genes, as a causative mechanism of cleft lip and palate in humans and mice.

show abstract

Section: Micrornas Related To Cleft Lipmentioning

confidence: 99%

MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate

Iwaya

Suzuki

Iwata

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…MiR-133b has been described as an anti-angiomiR in murine models of diabetic retinopathy, in which treatment of retinal microvascular endothelial cells with upregulation of miR-133b resulted in impaired proliferation and migration with upregulation of apoptosis ( 155 ). Zhong et al ( 156 ) examined the relationship between miR-133b and EGFR after confirming EGFR as a direct target of miR-133b via luciferase assay and observing downregulation of EGFR in high glucose-treated HUVECs.…”

Section: Dysregulated Micrornas In Diabetic Angiogenesismentioning

confidence: 99%

Effects of microRNAs on angiogenesis in diabetic wounds

et al. 2023

View full text Add to dashboard Cite

Diabetes mellitus is a morbid condition affecting a growing number of the world population, and approximately one third of diabetic patients are afflicted with diabetic foot ulcers (DFU), which are chronic non-healing wounds that frequently progress to require amputation. The treatments currently used for DFU focus on reducing pressure on the wound, staving off infection, and maintaining a moist environment, but the impaired wound healing that occurs in diabetes is a constant obstacle that must be faced. Aberrant angiogenesis is a major contributor to poor wound healing in diabetes and surgical intervention is often necessary to establish peripheral blood flow necessary for healing wounds. Over recent years, microRNAs (miRNAs) have been implicated in the dysregulation of angiogenesis in multiple pathologies including diabetes. This review explores the pathways of angiogenesis that become dysregulated in diabetes, focusing on miRNAs that have been identified and the mechanisms by which they affect angiogenesis.

show abstract

“…Furthermore, EVs can themselves be therapeutic or serve as delivery vehicles for encapsulated therapeutic molecules (drugs, peptides, small molecules) and notably both of these approaches have been utilized for several eye diseases including specific retinal disease (Table 3). (Aboul Naga et al, 2015;Moisseiev et al, 2017;Zhu et al, 2017;Zhou et al, 2018;Xu et al, 2019;Bian et al, 2020;Kang et al, 2020;Dong et al, 2021;Gu et al, 2021;Tian et al, 2021;Wang T et al, 2021;Wang W et al, 2021;Zhou et al, 2021;Liang et al, 2022;Lin et al, 2022;Liu Y et al, 2022;Pollalis et al, 2022;Ren et al, 2022;Zhou et al, 2022) To date, two different modes of encapsulating molecules, active and passive, have been used with EVs. Active encapsulation includes sonication of drugs or molecules in the cells.…”

Section: Ev-based Therapeutics For Retinal Diseasesmentioning

confidence: 99%

“…Mechanistically, this was due to the internalization of mNPC-exosomes by the retinal microglia, which suppressed their activation. Recently, bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-133b-3p suppressed angiogenesis and oxidative stress in a mouse model of DR ( Liang et al, 2022 ). Furthermore, BMSC-derived exosomes co-cultured with high glucose-treated Muller glial cells inhibited oxidative stress, inflammation, apoptosis, and promoted cell proliferation in a DR model ( Li W et al, 2021 ).…”

Section: Ev-based Therapeutics For Retinal Diseasesmentioning

confidence: 99%

Extracellular vesicles: an emerging player in retinal homeostasis

Chatterjee

Singh

2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Extracellular vesicles (EVs) encompass secreted membrane vesicles of varied sizes, including exosomes (−30–200 nm) and microvesicles (MVs) that are ∼100–1,000 nm in size. EVs play an important role in autocrine, paracrine, and endocrine signaling and are implicated in myriad human disorders including prominent retinal degenerative diseases, like age related macular degeneration (AMD) and diabetic retinopathy (DR). Studies of EVs in vitro using transformed cell lines, primary cultures, and more recently, induced pluripotent stem cell derived retinal cell type(s) (e.g., retinal pigment epithelium) have provided insights into the composition and function of EVs in the retina. Furthermore, consistent with a causal role of EVs in retinal degenerative diseases, altering EV composition has promoted pro-retinopathy cellular and molecular events in both in vitro and in vivo models. In this review, we summarize the current understanding of the role of EVs in retinal (patho)physiology. Specifically, we will focus on disease-associated EV alterations in specific retinal diseases. Furthermore, we discuss the potential utility of EVs in diagnostic and therapeutic strategies for targeting retinal diseases.

show abstract

Exosomal microRNA-133b-3p from bone marrow mesenchymal stem cells inhibits angiogenesis and oxidative stress via FBN1 repression in diabetic retinopathy

Cited by 21 publications

References 30 publications

MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate

MicroRNAs and Gene Regulatory Networks Related to Cleft Lip and Palate

Effects of microRNAs on angiogenesis in diabetic wounds

Extracellular vesicles: an emerging player in retinal homeostasis

Contact Info

Product

Resources

About