Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice

Nie, Hezhongrong; Pan, Yong; Zhou, Yiwen

doi:10.1016/j.bbrc.2018.08.113

Cited by 30 publications

(28 citation statements)

References 33 publications

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“…In silico analysis suggested connection among miR-194 and T2DM due to prediction of targeting several important genes critical for insulin (e.g., AKT2, FOXO1, GRB10) and AMPK signaling (e.g., ATM, MAPK1) [210]. Another interesting study showed that upregulation of miR-194 in obese mice causes heart failure and mitochondrial dysfunction [211]. It is well known, that obese heart is characterized by reduced rates of oxidative phosphorylation (OXPHOS) and diminished efficiency in ATP synthesis [212].…”

Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 99%

“…It is well known, that obese heart is characterized by reduced rates of oxidative phosphorylation (OXPHOS) and diminished efficiency in ATP synthesis [212]. Nie et al established a considerable decrease of mitochondrial complex I activity, oxygen consumption and ATP production in cardiac tissues of obese mice, followed by severe heart injury [211]. Finally, Jaeger et al revealed elevated serum levels of miR-192, miR-194 and miR-215 linked with the presence of both T1DM and T2DM in patients, whereas miR-192 and miR-194 were correlated with the incidence of new-onset T2DM in 6 years of follow-up.…”

Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 99%

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The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 99%

Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…The endogenous basal oxygen consumption was measured with a clark electrode in a water-jacketed chamber connected to a circulating water bath (Hansatech, Norfolk, UK). For enzyme activity of mitochondrial complex I, mitochondria were isolated and measured according to the method described in previous report (Nie et al 2017(Nie et al , 2018. The complex I activity was expressed as a ratio to citrate synthase activity to account for mitochondrial enrichment.…”

Section: Mitochondrial Functional Analysismentioning

confidence: 99%

Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice

Wang

Liu

et al. 2019

Journal of Molecular Endocrinology

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The prevalence of obesity is dramatic increased and strongly associated with cardiovascular disease. Adipokines, secreted from adipose tissues, are critical risk factors for the development of cardiomyopathy. Present study aimed to investigate the pathophysiological role of autotaxin in obesity-related cardiomyopathy. In high-fat diet-fed mice, autotaxin was mainly synthesized and secreted from adipocytes. The increased accumulation of cardiac autotaxin was positively associated with cardiac dysfunction in obese mice. Interestingly, specific blockage of adipose tissue autotaxin effectively protected against high-fat diet-induced cardiac structural disorders, left ventricular hypertrophy and dysfunction. Inhibition of autotaxin further improved high-fat diet-induced cardiac fibrosis and mitochondrial dysfunction, including improvement of mitochondrial structure, mass and activities. Our findings demonstrated intervention of adipose tissue biology could influence cardiac modification in obese mice, and adipocyte-derived autotaxin was a potential diagnostic marker and therapeutic target for obesity-related cardiomyopathy.

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“…Recently, several studies have shown the importance of exosomal miRNA in diet induced complexities. For instance, exosomal miR-194 plays a crucial role in the cardiac function and mitochondrial activity in high-fat diet-induced mice as well as in human subjects ( Nie et al., 2018 ). The upregulation of exosomal miR-194 was closely related to the impaired cardiac function in human subjects.…”

Section: Macronutrients Can Influence Mirna Expression and Functionmentioning

confidence: 99%

“…The upregulation of exosomal miR-194 was closely related to the impaired cardiac function in human subjects. In addition, it has also been shown that exosomes derived from obese mice are involved in the impairment of mitochondrial activity in myocyte through reduced ATP production ( Nie et al., 2018 ), however, the use of miR-194 sponge improved the cardiac function in in vivo mouse model. Similar studies reported the involvement of exosomal miR-29a ( Li et al., 2019 ) and exosomal miR-122 ( Wang et al., 2019 ) in cardiac function in high-fat diet-induced obese mice and mitochondrial activity in cardiomyocyte.…”

Section: Macronutrients Can Influence Mirna Expression and Functionmentioning

confidence: 99%

Macronutrient modulation of mRNA and microRNA function in animals: A review

Sohel

2020

Animal Nutrition

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Dietary macronutrients have been regarded as a basic source of energy and amino acids that are necessary for the maintenance of cellular homeostasis, metabolic programming as well as protein synthesis. Due to the emergence of “nutrigenomics”, a unique discipline that combines nutritional and omics technologies to study the impacts of nutrition on genomics, it is increasingly evident that macronutrients also have a significant role in the gene expression regulation. Gene expression is a complex phenomenon controlled by several signaling pathways and could be influenced by a wide variety of environmental and physiological factors. Dietary macronutrients are the most important environmental factor influencing the expression of both genes and microRNAs (miRNA). miRNA are tiny molecules of 18 to 22 nucleotides long that regulate the expression of genes. Therefore, dietary macronutrients can influence the expression of genes in both direct and indirect manners. Recent advancements in the state-of-the-art technologies regarding molecular genetics, such as next-generation sequencing, quantitative PCR array, and microarray, allowed us to investigate the occurrence of genome-wide changes in the expression of genes in relation to augmented or reduced dietary macronutrient intake. The purpose of this review is to accumulate the current knowledge focusing on macronutrient mediated changes in the gene function. This review will discuss the impact of altered dietary carbohydrate, protein, and fat intake on the expression of coding genes and their functions. In addition, it will also summarize the regulation of miRNA, both cellular and extracellular miRNA, expression modulated by dietary macronutrients.

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Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice

Cited by 30 publications

References 33 publications

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice

Macronutrient modulation of mRNA and microRNA function in animals: A review

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