Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes

Zhao, Dan; Wu, Kerui; Sharma, Sambad; Xing, Fei; Wu, Soon‐Yi; Tyagi, Abhishek; Deshpande, Ravindra Pramod; Singh, Ravi; Wabitsch, Martin; Mo, Yin‐Yuan; Watabe, Kounosuke

doi:10.1038/s41467-022-35305-2

Cited by 17 publications

(10 citation statements)

References 83 publications

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“…[143] At the same time, next-generation sequencing and CRISPR-Cas have been used to identify single nucleotide polymorphisms (SNPs) that distinguish similar miRNA generations during biogenesis and influence disease. [144] This literature review focuses on cellular and exosome-derived miRNAs as biomarkers, and their diagnostic and prognostic value in breast cancer at the clinical level. It presents a comprehensive perspective to understanding breast disease, subtyping and staging breast cancer, breast cancer regulatory mechanisms and pathways, and predicting disease outcomes during treatment using miRNAs.…”

Section: Discussionmentioning

confidence: 99%

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Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Zablon,

Desai,

Dellinger

et al. 2024

Advanced Biology

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Breast cancer accounts for the highest cancer cases globally, with 12% of occurrences progressing to metastatic breast cancer with a low survival rate and limited effective early intervention strategies augmented by late diagnosis. Moreover, a low concentration of prognostic and predictive markers hinders disease monitoring. Circulating and exosomal microRNAs (miRNAs) have recently shown a considerable interplay in breast cancer, standing out as effective diagnostic and prognostic markers. The primary functions are as gene regulatory agents at the genetic and epigenetic levels. An array of dysregulated miRNAs stimulates cancer‐promoting mechanisms, activating oncogenes and controlling tumor‐suppressing genes and mechanisms. Exosomes are vastly studied extracellular vesicles, carrying, and transporting cargo, including noncoding RNAs with premier roles in oncogenesis. Translocation of miRNAs from the circulation to exosomes, with RNA‐binding proteins in stress‐induced conditions, has shown significant cooperation in function to promote breast cancer. This review examines cellular and exosomal miRNA biogenesis and loading, the clinical implications of their dysregulation, their function in diagnosis, prognosis, and prediction of breast cancer, and in regulating cancer signaling pathways. The influence of cellular and exosomal miRNAs presents clinical significance on breast cancer diagnosis, subtyping, staging, prediction, and disease monitoring during treatment, hence a potent marker for breast cancer.

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Section: Discussionmentioning

confidence: 99%

“…[ 143 ] At the same time, next‐generation sequencing and CRISPR‐Cas have been used to identify single nucleotide polymorphisms (SNPs) that distinguish similar miRNA generations during biogenesis and influence disease. [ 144 ]…”

Section: Discussionmentioning

confidence: 99%

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Zablon,

Desai,

Dellinger

et al. 2024

Advanced Biology

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“…Increasing evidence indicates that miRNAs also serve as candidate genes for many important traits, including fertility and disease traits [ 25 , 49 , 50 ]; however, they have shorter sequences and relatively fewer variants than protein-encoding genes and lncRNAs. In domestic animals, some miRNA variants are associated with economically important traits.…”

Section: Discussionmentioning

confidence: 99%

miR-423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

Li,

Zhang,

Wang

et al. 2023

J Animal Sci Biotechnol

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Background Atresia and degeneration, a follicular developmental fate that reduces female fertility and is triggered by granulosa cell (GC) apoptosis, have been induced by dozens of miRNAs. Here, we report a miRNA, miR-423, that inhibits the initiation of follicular atresia (FA), and early apoptosis of GCs. Results We showed that miR-423 was down-regulated during sow FA, and its levels in follicles were negatively correlated with the GC density and the P4/E2 ratio in the follicular fluid in vivo. The in vitro gain-of-function experiments revealed that miR-423 suppresses cell apoptosis, especially early apoptosis in GCs. Mechanically speaking, the miR-423 targets and interacts with the 3'-UTR of the porcine SMAD7 gene, which encodes an apoptosis-inducing factor in GCs, and represses its expression and pro-apoptotic function. Interestingly, FA and the GC apoptosis-related lncRNA NORHA was demonstrated as a ceRNA of miR-423. Additionally, we showed that a single base deletion/insertion in the miR-423 promoter is significantly associated with the number of stillbirths (NSB) trait of sows. Conclusion These results demonstrate that miR-423 is a small molecule for inhibiting FA initiation and GC early apoptosis, suggesting that treating with miR-423 may be a novel approach for inhibiting FA initiation and improving female fertility.

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“…Cancer-related adipocytes (CAAs) have also recently received a considerable amount of attention from researchers based on the analysis of patient serum-derived exosomes [62]. Zhao et al noted that BC cell-derived exosomes activate CAA by delivering miR-1304-3p, accelerating adipocyte differentiation and lipid accumulation, targeting the antiadipogenic gene GATA2 to exert a pro-carcinogenic effect, and potentially enabling the prediction of the prognosis of African American patients [74]. BC cell-derived exosomes deliver miR-155 to target UBQLN1 in adipocytes, inhibit white adipose tissue browning, and promote fat reduction related to cancer cachexia [75].…”

Section: Roles Of Cancer-derived Exosomes In the Bc Microenvironmentmentioning

confidence: 99%

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

Wang,

Shen

et al. 2024

IJMS

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Breast cancer (BC) is a global health risk for women and has a high prevalence rate. The drug resistance, recurrence, and metastasis of BC affect patient prognosis, thus posing a challenge to scientists. Exosomes are extracellular vesicles (EVs) that originate from various cells; they have a double-layered lipid membrane structure and contain rich biological information. They mediate intercellular communication and have pivotal roles in tumor development, progression, and metastasis and drug resistance. Exosomes are important cell communication mediators in the tumor microenvironment (TME). Exosomes are utilized as diagnostic and prognostic biomarkers for estimating the treatment efficacy of BC and have the potential to function as tools to enable the targeted delivery of antitumor drugs. This review introduces recent progress in research on how exosomes influence tumor development and the TME. We also present the research progress on the application of exosomes as prognostic and diagnostic biomarkers and drug delivery tools.

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Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes

Cited by 17 publications

References 83 publications

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

miR-423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

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