Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Lv, Lin‐Li; Feng, Yan; Wu, Min; Wang, Bin; Li, Zuo‐Lin; Zhong, Xin; Wu, Weijun; Chen, Jun; Ni, Haifeng; Tang, Tao-Tao; Tang, Ri‐Ning; Lan, Hui‐Yao; Liu, Bi-Cheng

doi:10.1038/s41418-019-0349-y

Cited by 285 publications

(240 citation statements)

References 33 publications

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“…The expression of the exocrine marker proteins CD9, CD63 and CD81 was increased. High glucose induces the upregulation of miR‐27a, miR‐155, miR‐19b‐3p and miRNA‐23a expression in TECs and activation of the inflammatory response by targeting NF‐κB . Inflammatory factors act on vascular endothelial cells, inducing expression of procoagulant factors and adhesion molecules that adhere to inflammatory cells, promoting intravascular thrombosis, increasing capillary permeability and inducing endothelial cell dysfunction.…”

Section: The Role Of Crosstalk Between Tecs and Gecs In Dkdmentioning

confidence: 99%

Crosstalk between tubular epithelial cells and glomerular endothelial cells in diabetic kidney disease

Chen

Liu

et al. 2020

Cell Proliferation

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In recent years, although the development of clinical therapy for diabetic kidney disease (DKD) has made great progress, the progression of DKD still cannot be controlled. Therefore, further study of the pathogenesis of DKD and improvements in DKD treatment are crucial for prognosis. Traditional studies have shown that podocyte injury plays an important role in this process. Recently, it has been found that glomerulotubular balance and tubuloglomerular feedback (TGF) may be involved in the progression of DKD. Glomerulotubular balance is the specific gravity absorption of the glomerular ultrafiltrate by the proximal tubules, which absorbs only 65% to 70% of the ultrafiltrate. This ensures that the urine volume will not change much regardless of whether the glomerular filtration rate (GFR) increases or decreases. TGF is one of the significant mechanisms of renal blood flow and self‐regulation of GFR, but how they participate in the development of DKD in the pathological state and the specific mechanism is not clear. Injury to tubular epithelial cells (TECs) is the key link in DKD. Additionally, injury to glomerular endothelial cells (GECs) plays a key role in the early occurrence and development of DKD. However, TECs and GECs are close to each other in anatomical position and can crosstalk with each other, which may affect the development of DKD. Therefore, the purpose of this review was to summarize the current knowledge on the crosstalk between TECs and GECs in the pathogenesis of DKD and to highlight specific clinical and potential therapeutic strategies.

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Section: The Role Of Crosstalk Between Tecs and Gecs In Dkdmentioning

confidence: 99%

Crosstalk between tubular epithelial cells and glomerular endothelial cells in diabetic kidney disease

Chen

Liu

et al. 2020

Cell Proliferation

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“…Exosomes contain various types of molecules, such as lipids, proteins, lipid rafts, mRNAs, miRNAs, and other non-coding RNAs, such as long non-coding RNAs (lncRNAs) (Zhang et al, 2015). Various cell types can release exosomes, such as reticulocytes (Pan and Johnstone, 1983;Diaz-Varela et al, 2018), dendritic cells (Morelli et al, 2004;Huang et al, 2019), B cells (Benjamin et al, 2019, mast cells (Xie et al, 2018), T cells , epithelial cells (Lv et al, 2019), and tumor cells (McAtee et al, 2019).…”

Section: Description Of Exosomesmentioning

confidence: 99%

Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?

2020

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MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19-25 nucleotides that are involved in regulating a range of developmental and physiological processes. Non-exosomal circulating and exosomal miRNAs have also been proposed to be useful in diagnostics as biomarkers for diseases and different types of cancer. In this review, the quantity of miRNAs and of reliable experimental data analyses of miRNAs that come from exosomal and non-exosomal sources are discussed from the perspective of their use as biomarkers for cancer and other diseases, including viral infections, nervous system disorders, cardiovascular disorders, and diabetes. We summarize other research findings regarding the use of miRNA from these two sources as biomarkers in diagnostics and clinical use. The challenges in using miRNA from these two sources in cancer and disease diagnostics are evaluated and discussed. Validation of specific miRNA signatures as biomarkers is a critical milestone in diagnostics.

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“…Increased exosomal miR-19b-3p in lipopolysaccharide-induced AKI. (Lv et al, 2019) Therapeutics Serum (mouse)/ myoblast (mouse)…”

Section: Renal Tubular Epithelial Cells (Mouse)mentioning

confidence: 99%

Section: Acute Kidney Injurymentioning

confidence: 99%

“…A most recent transcriptomics study has revealed that exosomal miR-19b-3p derived from renal tubular epithelial cells was elevated in mice with lipopolysaccharide-induced AKI (Lv et al, 2019). This molecule has been proposed to play a critical pathogenic role in tubulointerstitial inflammation by recruiting macrophage infiltration (Lv et al, 2019). Moreover, studies of cisplatin-induced AKI have revealed the increased level of fetuin-A but decreased level of AQP-2 in urinary exosomes from the AKI animals (Zhou et al, 2006;Sonoda et al, 2019a;Sonoda et al, 2019b).…”

Section: Acute Kidney Injurymentioning

confidence: 99%

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Roles for Exosome in Various Kidney Diseases and Disorders

Thongboonkerd

2020

Front. Pharmacol.

110

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Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Cited by 285 publications

References 33 publications

Crosstalk between tubular epithelial cells and glomerular endothelial cells in diabetic kidney disease

Crosstalk between tubular epithelial cells and glomerular endothelial cells in diabetic kidney disease

Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?

Roles for Exosome in Various Kidney Diseases and Disorders

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