Exosomal miRNA-223-3p derived from tumor associated macrophages promotes pulmonary metastasis of breast cancer 4T1 cells

Wang, Ziyuan; Zhang, Chen; Guo, Jian; Wang, Wei; Qin, Si; Chen, Chong; Luo, Yunping; Duan, Zhiqing

doi:10.1016/j.tranon.2023.101715

Cited by 11 publications

(3 citation statements)

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“…Furthermore, the sorting of miR-122-5p by extracellular vesicles (EVs), mediated by heterogeneous nuclear ribonucleoprotein A2B1, is implicated in promoting lung cancer progression ( 39 ). Additionally, exosomal miRNA-223-3p derived from tumor-associated macrophages promotes lung metastasis in breast cancer 4T1 cells ( 40 ). Exosomal miRNA-26b-5p is found to downregulate activating transcription factor 2, enhancing radiosensitivity in lung adenocarcinoma cells ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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BackgroundLung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis.MethodsPublications related to exosomes in lung cancer patients were systematically searched on the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, and the R package “Bibliometrics”. Publications were quantitatively analyzed using Microsoft Office Excel 2019. The language of publication was restricted to “English” and the search strategy employed TS=(exosomes or exosomes or exosomes) and TS=(lung cancer). The search period commenced on January 1, 2004, and concluded on November 12, 2023, at noon. The selected literature types included Articles and Reviews.ResultsThe study encompassed 1699 papers from 521 journals across 71 countries and 2105 institutions. Analysis revealed a consistent upward trend in lung cancer exosome research over the years, with a notable surge in recent times. This surge indicates a growing interest and depth of inquiry into lung cancer exosomes. Major research institutions in China and the United States, including Nanjing Medical University, Shanghai Jiao Tong University, Chinese Academy Of Sciences, and Utmd Anderson Cancer Center, emerged as crucial research hubs. The annual publication count in this field witnessed a continuous rise, particularly in recent years. Key terms such as lung cancer, non-small cell lung cancer (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, and oncology dominated the research landscape. Fields like cell biology, biochemistry, biotechnology, and oncology exhibited close relation with this research. Clotilde Théry emerged as the most cited author in the field, underlining her significant contributions. These results demonstrate the broad impact of exosome research in lung cancer, with key terms covering not only disease-specific aspects such as lung cancer and NSCLC but also basic biological concepts like microvesicles and intercellular communication. Explorations into exosomal microRNAs and oncology have opened new avenues for lung cancer exosome research. In summary, lung cancer exosome research is poised to continue receiving attention, potentially leading to breakthroughs in treatment and prevention.ConclusionPublications on lung cancer exosomes show a rising trend year by year, with China and the United States ranking first and second in terms of the number of publications. However, there is insufficient academic learning cooperation and exchanges between the two sides, and Chinese universities account for a large proportion of research institutions in this field. Jing Li is the most productive author, Clotilde Théry is the most co-cited author, and Cancers is the journal with the highest number of publications. The current focus in the field of lung cancer exosomes is on biomarkers, liquid biopsies, immunotherapy, and tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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“…Exosomal miR-503-3p generated from macrophages upregulated DACT2, inhibited glycolysis through the Wnt/β-catenin signaling pathway, and promoted oxidative phosphorylation in the mitochondria of BC cells [87]. In vivo experiments revealed that TAM-derived exosomal miR-223-3p can be delivered to 4T1 cells and facilitate lung metastasis in BC patients by targeting Cbx5 [88]. Yu et al investigated how TAM-derived exosomes influence tumor recurrence and metastasis after chemotherapy.…”

Section: Effects Of Immune Cell-derived Exosomesmentioning

confidence: 99%

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

Wang,

Shen

et al. 2024

IJMS

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Breast cancer (BC) is a global health risk for women and has a high prevalence rate. The drug resistance, recurrence, and metastasis of BC affect patient prognosis, thus posing a challenge to scientists. Exosomes are extracellular vesicles (EVs) that originate from various cells; they have a double-layered lipid membrane structure and contain rich biological information. They mediate intercellular communication and have pivotal roles in tumor development, progression, and metastasis and drug resistance. Exosomes are important cell communication mediators in the tumor microenvironment (TME). Exosomes are utilized as diagnostic and prognostic biomarkers for estimating the treatment efficacy of BC and have the potential to function as tools to enable the targeted delivery of antitumor drugs. This review introduces recent progress in research on how exosomes influence tumor development and the TME. We also present the research progress on the application of exosomes as prognostic and diagnostic biomarkers and drug delivery tools.

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“…In a murine experimental model, TAMs release exosomal miR-223-3p, which specifically supports the pulmonary metastasis of 4T1 cells [ 156 ]. In addition to TAM-derived EVs, recent work by Tang et al demonstrated both in vitro and in a TNBC murine experimental model that BC small extracellular vesicles (sEVs) carrying miR-106b-5p and miR-18a-5p trigger M2 polarization and PD-L1 expression in macrophages [ 157 ].…”

Section: Introductionmentioning

confidence: 99%

Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment

Ruocco,

Gisonna,

Acampora

et al. 2024

IJMS

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Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues. In particular, the cross talk of immune cells and their interactions with cancer cells dramatically influence BC dissemination, immunoediting, and the outcomes of cancer therapies. Tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) represent prominent immune cell populations of breast TMEs, and they have important roles in cancer immunoescape and dissemination. Therefore, in this article we review the features of TILs, TAMs, and MDSCs in BCs. Moreover, we highlight the mechanisms by which these immune cells remodel the immune TME and lead to breast cancer metastasis.

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Exosomal miRNA-223-3p derived from tumor associated macrophages promotes pulmonary metastasis of breast cancer 4T1 cells

Cited by 11 publications

References 38 publications

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment

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