Exosome and virus infection

Peng, Yiqiu; Yang, Yuxi; Li, Yingying; Shi, Tingjuan; Luan, Yingyi; Yin, Chenghong

doi:10.3389/fimmu.2023.1154217

Cited by 29 publications

(12 citation statements)

References 123 publications

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“…Numerous studies have shown that exosome biogenesis in infected cells was altered, leading to increases in their production and modifications in their content. Such results were obtained for in vitro infections with several phylogenetically unrelated families of both RNA and DNA viruses, and confirmed by analyses of biological samples, e.g., patient plasma [120][121][122][123][124][125]. In particular, an increase in exosome quantity has been revealed in the case of infection with flaviviruses, notably Dengue (DENV) and Zika (ZIKV) viruses.…”

Section: Exosomes and Biology Of Infectionmentioning

confidence: 57%

Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design

El Safadi,

Mokhtari,

Krejbich

et al. 2024

Vaccines

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Exosomes are small subtypes of extracellular vesicles (EVs) naturally released by different types of cells into their environment. Their physiological roles appear to be multiple, yet many aspects of their biological activities remain to be understood. These vesicles can transport and deliver a variety of cargoes and may serve as unconventional secretory vesicles. Thus, they play a crucial role as important vectors for intercellular communication and the maintenance of homeostasis. Exosome production and content can vary under several stresses or modifications in the cell microenvironment, influencing cellular responses and stimulating immunity. During infectious processes, exosomes are described as double-edged swords, displaying both beneficial and detrimental effects. Owing to their tractability, the analysis of EVs from multiple biofluids has become a booming tool for monitoring various pathologies, from infectious to cancerous origins. In this review, we present an overview of exosome features and discuss their particular and ambiguous functions in infectious contexts. We then focus on their properties as diagnostic or therapeutic tools. In this regard, we explore the capacity of exosomes to vectorize immunogenic viral antigens and their function in mounting adaptive immune responses. As exosomes provide interesting platforms for antigen presentation, we further review the available data on exosome engineering, which enables peptides of interest to be exposed at their surface. In the light of all these data, exosomes are emerging as promising avenues for vaccine strategies.

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Section: Exosomes and Biology Of Infectionmentioning

confidence: 57%

Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design

El Safadi,

Mokhtari,

Krejbich

et al. 2024

Vaccines

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“…Exosomes are heterogeneous nanosomes that mediate intercellular communication. [ 36 ] As an important biological carrier, exosomes have been proved to contain a variety of substances including circRNA. [ 37,38 ] Given the importance of circRNA in the progression of cancer, the detection of exosomal RNA in patient body fluids is of great value for the diagnosis and prognosis of cancer.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Liu,

Wu,

Wang

et al. 2024

J Biochem & Molecular Tox

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Circular RNA is an important regulator for non‐small cell lung cancer (NSCLC). Circ_0000735 has been found to be significantly overexpressed in NSCLC tissues. Therefore, its role and mechanism in NSCLC progression need to be further explored. The expression levels of circ_0000735, miR‐345‐5p and A disintegrin and metalloprotease 19 (ADAM19) were determined using quantitative real‐time PCR. EdU staining, wound healing and transwell assays were utilized to detect cell proliferation and metastasis. The protein levels of metastasis markers, exosome markers and ADAM19 were determined using western blot. Animal experiments were performed to confirm the role of circ_0000735 in NSCLC tumorigenesis. The exosomes from cells and serum were identified using transmission electron microscopy and nanoparticle tracking analysis. We found that circ_0000735 was upregulated in NSCLC, and its knockdown repressed NSCLC cell proliferation and metastasis. In terms of mechanism, circ_0000735 targeted miR‐345‐5p to regulate ADAM19. MiR‐345‐5p inhibitor reversed the suppressive effect of circ_0000735 knockdown on NSCLC progression, and ADAM19 overexpression abolished the inhibition effect of miR‐345‐5p on NSCLC progression. Also, animal experiments showed that silencing of circ_0000735 reduced NSCLC tumorigenesis. In addition, exosomes mediated the intercellular transmission of circ_0000735, and serum exosomal circ_0000735 might be an important indicator for the diagnosis of NSCLC. In conclusion, circ_0000735 facilitated NSCLC progression via miR‐345‐5p/ADAM19 pathway, and serum exosomal circ_0000735 might be a potential biomarker for NSCLC diagnosis.

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“…Based on their origins, exosomes can be classified into various types, such as tumor cell-derived vesicles, immune cell-derived vesicles, and stromal cell-derived vesicles. These vesicles play crucial roles in intercellular communication, 133 modulation of antiviral immune responses, 134 and participation in tissue repair. 135 The small size, modifiability, compositional diversity, and heterogeneity of exosomes make them a new class of effective nanodrugs.…”

Section: Advanced Nanotechnologiesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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Exosome and virus infection

Cited by 29 publications

References 123 publications

Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design

Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

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