Exosome-based vaccines and their position in next generation vaccines

Negahdaripour, Manica; Vakili, Bahare; Nezafat, Navid

doi:10.1016/j.intimp.2022.109265

Cited by 18 publications

(16 citation statements)

References 92 publications

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“…While exosomes and PROTACs hold promise in various aspects of medical research and drug development, they also face limitations and challenges within the field of vaccinology, which includes the development and deployment of vaccines: Exosomes in Vaccine Delivery: Exosomes, as promising carriers for vaccine delivery due to their natural cargo transportation ability, face challenges in translating preclinical success to clinical applications. Ensuring the safety, scalability, and efficacy of exosome-based vaccines in humans is an ongoing concern PROTACs in Vaccine Development: PROTACs are primarily used in the targeted degradation of specific proteins within cells, a concept that is not commonly associated with vaccine development .…”

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

“…Exosomes in Vaccine Delivery: Exosomes, as promising carriers for vaccine delivery due to their natural cargo transportation ability, face challenges in translating preclinical success to clinical applications. Ensuring the safety, scalability, and efficacy of exosome-based vaccines in humans is an ongoing concern …”

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

“…Ensuring the safety, scalability, and efficacy of exosome-based vaccines in humans is an ongoing concern. 135 PROTACs in Vaccine Development: PROTACs are primarily used in the targeted degradation of specific proteins within cells, a concept that is not commonly associated with vaccine development. 136 Their utilization in vaccines would require innovative approaches and may not be a conventional solution to common vaccine challenges.…”

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

“…Ensuring the safety, scalability, and efficacy of exosome-based vaccines in humans is an ongoing concern. 135 …”

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

See 3 more Smart Citations

Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy

Mohite,

Yadav,

Pandhare

et al. 2024

ACS Omega

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In the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional cancer vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration of the methodologies, clinical applications, success stories, and future prospects of these approaches. Traditional cancer vaccines have undergone significant advancements utilizing diverse modalities such as proteins, peptides, and dendritic cells. More recent innovations have focused on the physiological mechanisms enabling the human body to recognize and combat precancerous and malignant cells, introducing specific markers like peptide-based anticancer vaccines targeting tumor-associated antigens. Moreover, cancer viral vaccines, leveraging engineered viruses to stimulate immune responses against specific antigens, exhibit substantial promise in inducing robust and enduring immunity. Integration with complementary therapeutic methods, including monoclonal antibodies, adjuvants, and radiation therapy, has not only improved survival rates but also deepened our understanding of viral virulence. Recent strides in vaccine design, encompassing oncolytic viruses, virus-like particles, and viral vectors, mark the frontier of innovation. While these advances hold immense potential, critical challenges must be addressed, such as strategies for immune evasion, potential off-target effects, and the optimization of viral genomes. In the landscape of immunotherapy, noteworthy innovations take the spotlight from the use of immunomodulatory agents for the enhancement of innate and adaptive immune collaboration. The emergence of proteolysis-targeting chimeras (PROTACs) as precision tools for cancer therapy is particularly exciting. With a focus on various cancers, from melanoma to formidable solid tumors, this Review critically assesses types of cancer vaccines, mechanisms, barriers in vaccine therapy, vaccine efficacy, safety profiles, and immune-related adverse events, providing a nuanced perspective on the underlying mechanisms involving cytotoxic T cells, natural killer cells, and dendritic cells. The Review also underscores the transformative potential of cutting-edge technologies such as clinical studies, molecular sequencing, and artificial intelligence in advancing the field of cancer vaccines. These tools not only expedite progress but also emphasize the multidimensional and rapidly evolving nature of this research, affirming its profound significance in the broader context of cancer therapy. ■ UNRAVELING THE COMPLEXITY OF CANCER TREATMENT: A COMPREHENSIVE OVERVIEW OF MODERN INNOVATIONS AND EMERGING TECHNOLOGIESCancer, a word synonymous with uncertainty, suffering, and complexity, has emerged as a multifaceted challenge that transcends biological understanding and societal boundaries. As the leading cause of mortality worldwide, it prompts an immediate yet intricate response from the medical and scientific communities. The panorama of cancer is vast, encompassing various types and stages, ...

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Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

“…Ensuring the safety, scalability, and efficacy of exosome-based vaccines in humans is an ongoing concern. 135 …”

Section: Types Of Cancer Vaccines: a Comprehensive Overviewmentioning

confidence: 99%

See 2 more Smart Citations

Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy

Mohite,

Yadav,

Pandhare

et al. 2024

ACS Omega

View full text Add to dashboard Cite

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“…However, in the last decade, it has been shown that they have other key functions in both physiological and pathological processes. Regarding the physiological roles, exosomes play an important role in intercellular communication since they are able to deliver a number of bioactive cargos to near or distant target cells [126]. Moreover, exosomes display a role in tissue homeostasis and have antiinflammatory functions.…”

Section: Exosomesmentioning

confidence: 99%

A New Perspective for the Treatment of Alzheimer’s Disease: Exosome-Like Liposomes to Deliver Natural Compounds and RNA Therapies

Ribeiro¹,

Lopes²,

Gomes³

2023

Preprint

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With the increment of the aging population in recent years, neurodegenerative diseases exert a major global disease burden, essentially as a result of the lack of treatments that can stop the disease progression. Alzheimer’s Disease (AD) is an example of a neurodegenerative disease, that affects millions of people globally, with no effective treatment. Natural compounds have emerged as a viable therapy to fill a huge gap in AD management, and in recent years, mostly fuelled by the Covid-19 pandemic, RNA-based therapeutics have become a hot topic in the treatment of several diseases. Treatments of neurodegenerative diseases face significant limitations due to the complex and interconnected pathways that lead to their hallmarks and, also due to the necessity to cross the blood–brain barrier. Nanotechnology has contributed to surpass this bottleneck in the treatment of AD, by promoting safe and enhanced drug delivery to the brain. In particular, exosome-like nanoparticles, a hybrid delivery system combining exosomes and liposomes' advantageous features, are demonstrating great potential in the treatment of central nervous system diseases.

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Desai,

Chavda,

Singh

et al. 2024

Small

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Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art in cancer nanovaccine development, elucidating innovative strategies and technologies employed in their design. It explores both preclinical and clinical advancements, emphasizing key studies demonstrating their potential to elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, and the impact of nanoscale properties on vaccine performance. Detailed insights into the complex interplay between the tumor microenvironment and nanovaccine responses are provided, highlighting challenges and opportunities in optimizing therapeutic outcomes. Additionally, the study presents a thorough analysis of ongoing clinical trials, presenting a snapshot of the current clinical landscape. By curating the latest scientific findings and clinical developments, this study aims to serve as a comprehensive resource for researchers and clinicians engaged in advancing cancer immunotherapy. Integrating nanotechnology into vaccine design holds immense promise for revolutionizing cancer treatment paradigms, and this review provides a timely update on the evolving landscape of cancer nanovaccines.

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Exosome-based vaccines and their position in next generation vaccines

Cited by 18 publications

References 92 publications

Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy

Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of Immunotherapy

A New Perspective for the Treatment of Alzheimer’s Disease: Exosome-Like Liposomes to Deliver Natural Compounds and RNA Therapies

Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

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