Exosome-laden injectable self-healing hydrogel based on quaternized chitosan and oxidized starch attenuates disc degeneration by suppressing nucleus pulposus senescence

Guan, Ming; Liu, Can; Zheng, Qiangqiang; Chu, Guangyu; Wang, Hehui; Jin, Jiale; Wu, Honghao; Chen, Jingyao; Huang, Qiong; Deng, Zexing; Wang, Yue

doi:10.1016/j.ijbiomac.2023.123479

Cited by 24 publications

(15 citation statements)

References 40 publications

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“…39 By promoting the overall hydration of the NP tissue explant, the L-pNIPAM-co-DMAc hydrogel material effectively replicates the biomechanical properties observed in natural NP tissues. Consequently, the hydrogel is administered via minimally invasive injection into collagenase-digested bovine 41 Cartilaginous endplate stem cell Regulating autophagy and senescence in NPCs HDC Hydrogel 51,60 riboflavin Enhances IVD mechanical properties and promotes fiber ring repair Fibrin hydrogel 55 Genpin Supports disc cell growth and maintains tissue adhesion PEGDA/DAFM hydrogel 57 TGF-b1 Supports AF cell migration, adhesion, and proliferation, promotes ECM deposition, and closes AF defects PLGAmSphere-based IPN hydrogels 59…”

Section: Nucleus Pulposus Regeneration and Repairmentioning

confidence: 99%

“…These exosomes hold significant therapeutic promise due to their inheritable nature. 41,42 Hydrogel-encapsulated exosomes offer several advantageous properties, including enhanced stability, reduced susceptibility to degradation, and the ability to be effectively preserved. 43 In their scholarly work, Luo et al elucidated the characteristics of a hydrogel incorporated with a rib cartilage extracellular matrix and various cytokines.…”

Section: Msc-exosmentioning

confidence: 99%

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The current status and development trend of hydrogel application in spinal surgery

Qiu,

Cai,

Zhang

et al. 2024

J. Mater. Chem. B

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Section: Nucleus Pulposus Regeneration and Repairmentioning

confidence: 99%

Section: Msc-exosmentioning

confidence: 99%

The current status and development trend of hydrogel application in spinal surgery

Qiu,

Cai,

Zhang

et al. 2024

J. Mater. Chem. B

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“…In this regard, Guan et al developed a BM MSC-derived sEVsladen injectable self-healing HG based on quaternized chitosan & oxidized starch. [61] The local SC-sEV therapy alleviated oxidative stress-induced senescence in H 2 O 2 -treated NP cells, promoted ECM remodeling, and restored the structures of NP and annulus fibrosus (AF) in rats.…”

Section: Intervertebral Disc Degenerationmentioning

confidence: 99%

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Tan,

Xu,

et al. 2024

Advanced Therapeutics

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Stem cell‐derived small extracellular vesicles that are either naturally produced or pharmacogenetically engineered have shown tremendous potential in regenerative medicine in recent years. These sEVs exert multiple therapeutic effects comparable or superior to their parental stem cells while avoiding the limitations of stem cell‐based therapy, such as infusion toxicity, immunogenicity, tumorigenic potential, and ethical issues. The two routine modalities of sEV administration are systemic injection and local delivery, each presenting distinct benefits and drawbacks. Various biomaterials have been developed to assist their local delivery to improve the targeting of organs, minimize non‐specific accumulation in vital organs, and ensure the protection and release of sEVs. Based on a thorough search and meticulous dissection of relevant literature from the past five years, we present this comprehensive, up‐to‐date, specialty‐specific, disease‐oriented, and preclinical review to expound on the surgical application and potential of stem cell‐derived sEVs. The local delivery of stem cell‐derived sEVs, which possess similar indications as systemic transfer, could treat numerous diseases encountered in orthopedic surgery, neurosurgery, plastic surgery, cardiothoracic surgery, general surgery, urology, otorhinolaryngology, ophthalmology, obstetrics and gynecology, and dental surgery. In addition, the biomaterials utilized encompass a wide range of sources (e.g., natural, synthetic, and hybrid polymers), format (e.g., scaffold, patch, spray, microneedle), and responsiveness (e.g., temperature, pH, and protein), which enables customized sEV therapy tailored to specific diseases. This review demonstrates biomaterial‐facilitated local delivery of stem cell‐derived sEVs as a viable alternative or even a superior option to systemic sEV therapy. Future collaboration among surgeons, biomaterial scientists, and stem cell researchers is essential to advance this research area.This article is protected by copyright. All rights reserved

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“…Among various materials discussed previously, chitosan has shown its distinct position in the biomedical field because the presence of amino and hydroxyl groups allows chitosan to be modified: it has many smart characteristics such as pH-responsive, thermoresponsive, shape memory, and (bio)chemicals-responsive . pH-responsive materials are very useful for targeted drug delivery application, which can minimize the side effect suffered by the patient during the medication process. , The thermoresponsive properties of chitosan are exploited to fabricate an injectable hydrogel that is in the liquid phase at room temperature but the gel phase at body temperature, which has advantages in osteogenesis and wound healing applications. , The shape-memory characteristic of chitosan allows the development of a self-healing hydrogel for dynamic wound applications and shape-memory scaffolds to minimize invasive bone surgery, treating deep penetrating wounds, and synthesizing self-healing wound dressings. , …”

Section: Introductionmentioning

confidence: 99%

“…20,21 The shape-memory characteristic of chitosan allows the development of a self-healing hydrogel for dynamic wound applications and shape-memory scaffolds to minimize invasive bone surgery, treating deep penetrating wounds, and synthesizing self-healing wound dressings. 22,23 Considering research on chitosan-based smart biomaterial has grown rapidly in the past decades with many biomedical applications, researchers need an up-to-date review that discusses not only chitosan-based traditional biomaterials but also chitosan-based smart biomaterials. To the best of our knowledge, many reviews only focus on the general properties of chitosan and the strategy to optimize its pristine properties.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

show abstract

Exosome-laden injectable self-healing hydrogel based on quaternized chitosan and oxidized starch attenuates disc degeneration by suppressing nucleus pulposus senescence

Cited by 24 publications

References 40 publications

The current status and development trend of hydrogel application in spinal surgery

The current status and development trend of hydrogel application in spinal surgery

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

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