Exosome-mediated miR-222 transferring: An insight into NF-κB-mediated breast cancer metastasis

Ding, Jiong; Xu, Zhi; Zhang, Yanyan; Tan, Chunli; Hu, Weizi; Wang, Mei; Xu, Yong; Tang, Jinhai

doi:10.1016/j.yexcr.2018.05.014

Cited by 71 publications

(42 citation statements)

References 52 publications

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“…Furthermore, increased level of exosomal miR-222-3p in serum of the NSCLC patients was associated with poor prognosis [94, 95]. TDEs containing miR-222 enhanced the migration and invasion ability of breast cancer cells through down-regulation of PDLIM2- (a tumor suppressor) which lead to activation of NF-κB signaling pathway [96]. Studies on the metastatic niche have endorsed that high amounts of integrins and MMPs increase matrix and basement membrane degradation [97].…”

Section: Introductionmentioning

confidence: 99%

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

et al. 2019

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Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. Exosomes initiate or suppress various signaling pathways in the recipient cells via transmitting heterogeneous cargoes. In this review we discuss exosome biogenesis, exosome mediated metastasis and chemoresistance. Furthermore, tumor derived exosomes role in tumor microenvironment remodeling, and angiogenesis is reviewed. Also, exosome induction of epithelial mesenchymal transition (EMT) is highlighted. More importantly, we discuss extensively how exosomes regulate drug resistance in several cancers. Thus, understanding exosome biogenesis, their contents and the molecular mechanisms and signaling pathways that are responsible for metastasis and drug-resistance mediated by TDEs may help to devise novel therapeutic approaches for cancer progression particularly to overcome therapy-resistance and preventing metastasis as major factors of cancer mortality.

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Section: Introductionmentioning

confidence: 99%

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

et al. 2019

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“…The expression of multiple microRNA (miR) molecules and proteins in cervical cancer suggests that miRs may play important roles in the regulation of disease-related proteins (14). miR-222 is found to be abnormally expressed in many tumor tissues (15)(16)(17), and is associated with MDR (18,19). However, the regulatory relationship between miR-222 and ALDH1 in cervical cancer has, to the best of our knowledge, not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Aldehyde dehydrogenase 1, a target of miR‑222, is expressed at elevated levels in cervical cancer

et al. 2020

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The aim of the present study was to investigate the expression of microRNA-222 (miR-222) and aldehyde dehydrogenase 1 (ALDH1) in tissues and peripheral blood of cervical cancer patients, and to elucidate their underlying mechanisms of action. Tumor tissues and tumor-adjacent tissues were obtained from 33 cervical cancer patients and peripheral blood was obtained from these patients and 28 healthy subjects. The expression of miR-222 and ALDH1 mRNA was evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). To examine the levels of ALDH1 protein in tissues and blood, western blotting and ELISA were used. To confirm a direct interaction between miR-222 and ALDH1 mRNA, a dual luciferase reporter assay was performed. HeLA cells were transfected with agomiR-222 and expression of ALDH1 in the cells was measured by RT-qPCR and western blotting. MTT assay was preform to investigate the proliferation of HeLA cells. Expression of ALDH1 mRNA and protein was elevated in cervical cancer tissues and peripheral blood from patients compared with tumor-adjacent tissues and healthy controls, while the expression of miR-222 was reduced. Upregulation of miR-222 inhibited HeLA cell proliferation possibly due to a reduction in the expression of ALDH1. A dual luciferase reporter assay showed that miR-222 can bind with the 3'-untranslated seed region of ALDH1 mRNA to regulate its expression. miR-222 regulation of ALDH1 expression may play a role in the prevention of cervical cancer.

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“…When EVs-miR222, overexpressed in multiple types of cancer, was analyzed in plasma from breast cancer patients with and without lymph node metastasis, the highest level of miR-222 was metastatic patients. In the same study, the authors confirmed the EVs-miR-222 overexpression in more invasive breast cancer cell lines [89].…”

Section: Cancer Stagingmentioning

confidence: 63%

Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?

Martellucci

Orefice

Angelucci

et al. 2020

IJMS

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Extracellular Vesicles (EVs) represent a heterogeneous population of membranous cell-derived structures, including cargo-oriented exosomes and microvesicles. EVs are functionally associated with intercellular communication and play an essential role in multiple physiopathological conditions. Shedding of EVs is frequently increased in malignancies and their content, including proteins and nucleic acids, altered during carcinogenesis and cancer progression. EVs-mediated intercellular communication between tumor cells and between tumor and stromal cells can modulate, through cargo miRNA, the survival, progression, and drug resistance in cancer conditions. These consolidated suggestions and EVs’ stability in bodily fluids have led to extensive investigations on the potential employment of circulating EVs-derived miRNAs as tumor biomarkers and potential therapeutic vehicles. In this review, we highlight the current knowledge about circulating EVs-miRNAs in human cancer and the application limits of these tools, discussing their clinical utility and challenges in functions such as in biomarkers and instruments for diagnosis, prognosis, and therapy.

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Exosome-mediated miR-222 transferring: An insight into NF-κB-mediated breast cancer metastasis

Cited by 71 publications

References 52 publications

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Aldehyde dehydrogenase 1, a target of miR‑222, is expressed at elevated levels in cervical cancer

Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?

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