Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost, Yana; Muskat, Ahava; Mhaimeed, Nour; Nazarian, Roya; Kobets, Kseniya

doi:10.1111/jocd.15008

Cited by 21 publications

(30 citation statements)

References 62 publications

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“…However, specific guidelines on their use have not been generated. Furthermore, the use of exosomes in AGA is not well supported, as data showing clear efficacy and safety of exosomes for alopecia is lacking [ 82 ]. Additional research is necessary to justify the routine use of MSC–exosomes in treatment of AGA.…”

Section: Nonsurgical Nondrug Treatmentsmentioning

confidence: 99%

Androgenetic Alopecia: Therapy Update

Devjani

Ezemma

Kelley

et al. 2023

Drugs

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Androgenetic alopecia (AGA), also known as male pattern hair loss (MPHL) or female pattern hair loss (FPHL), is the most common form of alopecia worldwide, and arises from an excessive response to androgens. AGA presents itself in a characteristic distribution unique to both sexes. Despite its prevalence, AGA can be quite challenging to treat. The condition is chronic in nature and stems from an interplay of genetic and environmental factors. There are only two US Food and Drug Administration (FDA)-approved drugs for the condition: topical minoxidil and oral finasteride. However, numerous non-FDA-approved treatments have been shown to be effective in treating AGA in various studies. Some of these treatments are relatively new and still to be explored, thus emphasizing the need for an updated review of the literature. In this comprehensive review, we discuss the evaluation of AGA and the mechanisms of action, costs, efficacies, and safety profiles of existing, alternative, and upcoming therapeutics for this widespread condition.

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Section: Nonsurgical Nondrug Treatmentsmentioning

confidence: 99%

Androgenetic Alopecia: Therapy Update

Devjani

Ezemma

Kelley

et al. 2023

Drugs

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“…91,92 Compared with ADSC-assisted treatment, a novel strategy of exosomes as "cell-free therapy" not only mimics the capability of the original cells but also may effectively avoid limited implanted cell survival, foreign body reaction, immune-mediated rejection, and risk of tumorigenicity. 90,91,93,94 The most promising avenue for the treatment of hair loss is using exosomes from DP cells, DF cells, DP ORS cells coculture, and 3D-cultured DP cells (DP sphere). 93,95 A recent study also demonstrated that exosomes from 3Dcultured DP cells (3D DP-Exos) promoted the proliferation of DP and ORS cells and increased the expression of IGF-1, KGF, and HGF in DP cells.…”

Section: Exosomesmentioning

confidence: 99%

Medical Treatment for Androgenetic Alopecia

Panchaprateep

2023

Facial Plast Surg

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Androgenetic alopecia (AGA) is a common type of hair loss, which is generally influenced by genetic factors and systemic androgens resulting in follicular miniaturization1. It can cause cosmetic problems leading to psychological distress among affected men and women. Effective standard medical treatments available are topical minoxidil 2-5%, oral finasteride, oral dutasteride, and hair transplantation.1 However, some patients do not achieve favorable results with standard treatments. For these reasons, other novel treatments have been developed, including new medications, regenerative medicines (autologous platelet-rich plasma (PRP), adipose derived stem cells, micrograft generation and exosome) and low-level laser therapy (LLLT).

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“…DPCs serve as signaling centers in the hair follicle (HF) and play an important role in regulating hair growth, formation, and circulation. Exosomes can inhibit hair loss by inducing HF regeneration by promoting the proliferation of DPCs ( Kost et al, 2022 ).…”

Section: The Regulatory Mechanism Of Exosomes In Medical Aestheticsmentioning

confidence: 99%

Exosomes based advancements for application in medical aesthetics

Zhang

Gong²,

Li³

et al. 2022

Front. Bioeng. Biotechnol.

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Beauty is an eternal pursuit of all people. Wound repair, anti-aging, inhibiting hyperpigmentation and hair loss are the main demands for medical aesthetics. At present, the repair and remodeling of human body shape and function in medical aesthetics are often achieved by injection of antioxidants, hyaluronic acid and botulinum toxin, stem cell therapy. However, there are some challenges, such as difficulty controlling the injection dose, abnormal local contour, increased foreign body sensation, and the risk of tumor occurrence and deformity induced by stem cell therapy. Exosomes are tiny vesicles secreted by cells, which are rich in proteins, nucleic acids and other bioactive molecules. They have the characteristics of low immunogenicity and strong tissue penetration, making them ideal for applications in medical aesthetics. However, their low yield, strong heterogeneity, and long-term preservation still hinder their application in medical aesthetics. In this review, we summarize the mechanism of action, administration methods, engineered production and preservation technologies for exosomes in medical aesthetics in recent years to further promote their research and industrialization in the field of medical aesthetics.

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Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Cited by 21 publications

References 62 publications

Androgenetic Alopecia: Therapy Update

Androgenetic Alopecia: Therapy Update

Medical Treatment for Androgenetic Alopecia

Exosomes based advancements for application in medical aesthetics

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