Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing

Zhu, Ziying; Zhang, Xiaona; Hao, Haojie; Shu, Jun; Hou, Qi; Wang, Min

doi:10.3389/fncel.2022.913009

Cited by 31 publications

(18 citation statements)

References 124 publications

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“…It is quite possible that intact SVF or mesenchymal stem cells also accelerate the recovery process and repair the injured nerve endings. 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Claytor

Sheck²,

Jones

et al. 2023

Aesthetic Surgery Journal Open Forum

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Background Treating facial aging with CO2 lasering or microneedling are cornerstones of facial rejuvenation. Skin rejuvenation utilizing thermal and mechanical treatments have historically been considered too injurious to be combined at a single setting. Autologous nanofat has been shown to deliver wound healing properties. We investigated the safety and efficacy of co-terminus CO2 lasering and microneedling to resolve fine lines and rhytids in facial skin with addition of autologous nanofat to aid in recovery. Objectives Combination treatments may result in better results with faster recovery. We investigated the safety and efficacy of co-terminus CO2 lasering and microneedling to resolve fine lines and rhytids in facial skin with addition of autologous nanofat to aid in recovery. Methods Twenty-three patients underwent facial treatment with CO2 lasering followed by microneedling and application of autologous nanofat (LaMiNa). One volunteer patient had tissue biopsies of treatment areas to demonstrate histologic tissue level changes. Results All patients verbally reported no pain (NRS 0/10) following procedure and had rapid recovery within an average of 5 days. Pathology results demonstrated that CO2 and microneedling had persistent epidermal disruption and perineural inflammation at 4 days while the introduction of autologous nanofat at the time of CO2 and microneedling resulted in full recovery of epidermis and resolution of perineural inflammation. Conclusions Triple therapy (LaMiNa) with thermal CO2 remodeling and mechanical microneedling penetration have accelerated and pain free recovery with the addition of autologous nanofat. Histologic analysis reveals that epidermal recovery is accelerated and perineural inflammation is reduced with the addition of autologous nanofat following skin remodeling from combined CO2 and microneedling.

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“…It is quite possible that intact SVF or mesenchymal stem cells also accelerate the recovery process and repair the injured nerve endings. 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Claytor

Sheck²,

Jones

et al. 2023

Aesthetic Surgery Journal Open Forum

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“…Previous studies have shown that denervated skin contributes to adverse wound healing consequences. Zhu et al noted that hUC-MSC-exos could stimulate dermal fibroblasts to secrete nerve growth factors (NGFs) in vitro [ 65 ]. In a mouse model, hUC-MSC-exos could promote skin regeneration and full-thickness cutaneous wound healing by recruiting fibroblasts, stimulating their production of NGFs, and thereby promoting cutaneous nerve regeneration.…”

Section: Huc-mscsmentioning

confidence: 99%

Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

Zhou¹,

Zhang²,

Yang³

et al. 2023

Stem Cell Res Ther

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Wound healing is a dynamic and highly sequential process involving a series of overlapping spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal stem cells (MSCs) are multipotent stem cells with self-renewal, multidirectional differentiation potential, and paracrine regulation. Exosomes are subcellular vesicular components 30–150 nm in size and are novel carriers of intercellular communication in regulating the biological behaviors of skin cells. Compared to MSCs, MSC-derived exosomes (MSC-exos) possess lower immunogenicity, easy storage, and highly effective biological activity. MSC-exos, mainly derived from adipose-derived stem cells (ADSCs), bone marrow-derived MSCs (BMSCs), human umbilical cord MSCs (hUC-MSCs), and other stem cell types, play a role in shaping the activity of fibroblasts, keratinocytes, immune cells, and endothelial cells in diabetic wounds, inflammatory wound repair, and even wound-related keloid formation. Therefore, this study focuses on the specific roles and mechanisms of different MSC-exos in wound healing, as well as the current limitations and various perspectives. Deciphering the biological properties of MSC-exos is crucial to providing a promising cell-free therapeutic tool for wound healing and cutaneous regeneration. Graphical Abstract

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“…Further study revealed the mechanism for these effects involving inhibiting the expression of receptor for AGEs (RAGE) and stimulating the activation of Smad signaling pathway in these cells ( Bian et al, 2020 ; Zhao et al, 2021 ). Interestingly, Zhu and colleagues reported that hucMSC-sEVs could not only promote proliferation and migration of fibroblasts, but also remarkedly boost cutaneous nerve regeneration by stimulating fibroblasts to produce nerve growth factors (NGFs), which can stimulate nerve regeneration, re-establish local sensory innervation homeostasis, and enhance angiogenesis, thereby achieving an ideally regenerative healing both morphologically and functionally ( Zhu et al, 2022 ). Additionally, ADSC-Exos can transport miRNAs, lncRNA, and functional proteins ( Choi et al, 2018 ; Cooper et al, 2018 ; Parvanian et al, 2020 ; Qian et al, 2021 ) to promote the migration, proliferation, ECM secretion of fibroblasts ( Hu et al, 2016 ; Wang et al, 2021b ).…”

Section: Therapeutic Potential Of Msc-sevs For Chronic Non-healing Wo...mentioning

confidence: 99%

Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment

Wei

Liu

et al. 2023

Front. Bioeng. Biotechnol.

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Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing. Therefore, regulating and restoring normal cellular behavior is the core of chronic non-healing wound treatment. In recent years, the therapy with mesenchymal stem cells (MSCs) has become a promising option for chronic wound healing and the efficacy has increasingly been attributed to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) are reported to benefit almost all stages of wound healing by regulating the cellular behavior to participate in the process of inflammatory response, angiogenesis, re-epithelization, and scarless healing. Here, we describe the characteristics of MSC-sEVs and discuss their therapeutic potential in chronic wound treatment. Additionally, we also provide an overview of the application avenues of MSC-sEVs in wound treatment. Finally, we summarize strategies for large-scale production and engineering of MSC-sEVs. This review may possibly provide meaningful guidance for chronic wound treatment with MSC-sEVs.

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Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing

Cited by 31 publications

References 124 publications

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

LaMiNa: A Creative Synergistic Approach to Facial Rejuvenation

Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment

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