Exosomes from CD133+ human urine-derived stem cells combined adhesive hydrogel facilitate rotator cuff healing by mediating bone marrow mesenchymal stem cells

Tong, Xiaopeng; Xu, Yixin; Zhang, Tao; Deng, Chao; Xun, Jinrui; Sun, Dong; Xu, Daqi

doi:10.1016/j.jot.2023.02.002

Cited by 12 publications

(10 citation statements)

References 41 publications

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“…Xiaopeng Tong et al analyzed the function of hydrogels coated human urine-derived stem cells (USCs) exosomes on a rat rotator cuff tear model. The results proved its ability to heal tendon-bone interface (Tong et al, 2023). Jinwei Lu et al developed GelMA hydrogels coated platelet-derived exosomes and verified their capacity to promote tendon stem/ progenitor cell proliferation and regeneration, facilitating tendon repair (Lu et al, 2023).…”

Section: Hydrogels Coated Exosomes In Rotator Cuff Tear/ Tendon Repairmentioning

confidence: 95%

Role of nano-hydrogels coated exosomes in bone tissue repair

Pan

Dong

et al. 2023

Front. Bioeng. Biotechnol.

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With the development of nanotechnology, nanomaterials are widely applied in different areas. Some nanomaterials are designed to be biocompatible and can be used in the medical field, playing an important role in disease treatment. Exosomes are nanoscale vesicles with a diameter of 30–200 nm. Studies have shown that exosomes have the effect of angiogenesis, tissue (skin, tendon, cartilage, et al.) repair and reconstruction. Nano-hydrogels are hydrogels with a diameter of 200 nm or less and can be used as the carrier to transport the exosomes into the body. Some orthopedic diseases, such as bone defects and bone infections, are difficult to handle. The emergence of nano-hydrogels coated exosomes may provide a new idea to solve these problems, improving the prognosis of patients. This review summarizes the function of nano-hydrogels coated exosomes in bone tissue repair, intending to illustrate the potential use and application of nano-hydrogels coated exosomes in bone disease.

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Section: Hydrogels Coated Exosomes In Rotator Cuff Tear/ Tendon Repairmentioning

confidence: 95%

Role of nano-hydrogels coated exosomes in bone tissue repair

Pan

Dong

et al. 2023

Front. Bioeng. Biotechnol.

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“…Intriguingly, Tong et al discovered that sEVs from CD133 + urine-derived stem cells could facilitate rotator cuff healing by mediating BM MSCs. [55] Furthermore, Zhang et al proved that sEVs secreted by hypoxia-preconditioned BM MSCs could accelerate grafted tendon-bone tunnel healing by coupling with peri-graft bone and blood vessel microarchitecture. [56] Finally, Cai et al showed that sEVs derived from Kartogenin-stimulated BM MSCs, when loaded in a sodium alginate HG, could promote cartilage formation and collagen maturation for enthesis regeneration in chronic RCT.…”

Section: Muscle and Tendon Tearmentioning

confidence: 99%

“…discovered that sEVs from CD133 + urine‐derived stem cells could facilitate rotator cuff healing by mediating BM MSCs. [ 55 ] Furthermore, Zhang et al. proved that sEVs secreted by hypoxia‐preconditioned BM MSCs could accelerate grafted tendon‐bone tunnel healing by coupling with peri‐graft bone and blood vessel microarchitecture.…”

Section: Orthopedic and Trauma Surgery And Biomaterial‐assisted Sc‐se...mentioning

confidence: 99%

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Tan,

Xu,

et al. 2024

Advanced Therapeutics

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Stem cell‐derived small extracellular vesicles that are either naturally produced or pharmacogenetically engineered have shown tremendous potential in regenerative medicine in recent years. These sEVs exert multiple therapeutic effects comparable or superior to their parental stem cells while avoiding the limitations of stem cell‐based therapy, such as infusion toxicity, immunogenicity, tumorigenic potential, and ethical issues. The two routine modalities of sEV administration are systemic injection and local delivery, each presenting distinct benefits and drawbacks. Various biomaterials have been developed to assist their local delivery to improve the targeting of organs, minimize non‐specific accumulation in vital organs, and ensure the protection and release of sEVs. Based on a thorough search and meticulous dissection of relevant literature from the past five years, we present this comprehensive, up‐to‐date, specialty‐specific, disease‐oriented, and preclinical review to expound on the surgical application and potential of stem cell‐derived sEVs. The local delivery of stem cell‐derived sEVs, which possess similar indications as systemic transfer, could treat numerous diseases encountered in orthopedic surgery, neurosurgery, plastic surgery, cardiothoracic surgery, general surgery, urology, otorhinolaryngology, ophthalmology, obstetrics and gynecology, and dental surgery. In addition, the biomaterials utilized encompass a wide range of sources (e.g., natural, synthetic, and hybrid polymers), format (e.g., scaffold, patch, spray, microneedle), and responsiveness (e.g., temperature, pH, and protein), which enables customized sEV therapy tailored to specific diseases. This review demonstrates biomaterial‐facilitated local delivery of stem cell‐derived sEVs as a viable alternative or even a superior option to systemic sEV therapy. Future collaboration among surgeons, biomaterial scientists, and stem cell researchers is essential to advance this research area.This article is protected by copyright. All rights reserved

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“…Since the introduction and widespread application of cell-free therapies based on exosomes, extracellular vesicles derived from ADSCs, BMSCs, and urine-derived stem cells (USCs) have been proven to promote tendon repair by modulating the biological characteristics of TSCs and the extracellular microenvironment. Preconditioning such stem cells under hypoxic conditions has shown to be advantageous in promoting vascular generation and accelerating tendon-to-bone healing [ 235 , 296 , 297 ]. In another study, extracellular vesicle products derived from human platelets expressing CD41a and CD9 demonstrated extensive skeletal muscle regeneration in a rat model for volumetric muscle loss (VML) defect.…”

Section: Application Of the Hydrogel-exosome System For Tissue Repair...mentioning

confidence: 99%

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Fan,

Pi,

Zou

et al. 2024

Bioactive Materials

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Exosomes from CD133+ human urine-derived stem cells combined adhesive hydrogel facilitate rotator cuff healing by mediating bone marrow mesenchymal stem cells

Cited by 12 publications

References 41 publications

Role of nano-hydrogels coated exosomes in bone tissue repair

Role of nano-hydrogels coated exosomes in bone tissue repair

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

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