Exosomes in cutaneous biology and dermatologic disease

Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation

“…Studies have shown the anti‐inflammatory, regenerative, immunomodulatory, and anti‐prostaglandin effects of MSC exosomes, with proper homing, due to the multitude of robust growth factors, including TGFB3 and VEGF 1 . Histological verification of neocollagenesis, elastin production and angiogenesis has been shown in numerous exosome studies (4, 5, 6).…”

“…The fields of cellular medicine, regenerative and stem cell therapies continue to grow exponentially, particularly as it relates to therapeutics and diagnostics. Exosome research has progressed over the past two decades, culminating in thousands of peer‐reviewed publications 1 . The focus of early research was primarily on functional disorders, particularly degenerative and autoimmune diseases 2 .…”

“…Within this patient population exists a desire for minimally invasive, non‐surgical procedures seeking preventative aesthetic solutions to prolong the necessity for future corrective aesthetic therapies. This trend has fueled the current explosion in the expanding knowledge and study of placental mesenchymal stem cell‐derived vesicles or exosomes 1 . Mesenchymal Stem Cell Exosomes (MSC exosomes) are produced by stem cells of connective tissue lineage which is the origin of skin, hair, bone, muscle, and cartilage.…”

“…Exosome research has progressed over the past two decades, culminating in thousands of peer-reviewed publications. 1 The focus of early research was primarily on functional disorders, particularly degenerative and autoimmune diseases. 2 In recent years, more research has emerged focusing on aesthetic and reconstructive surgical applications.…”

“…This trend has fueled the current explosion in the expanding knowledge and study of placental mesenchymal stem cell-derived vesicles or exosomes. 1 with high-intensity LED therapy (SaltFacial®, SaltMed, Cardiff, CA), utilizing the collagen restoration preset program of combination red (660 nm) near-infrared (930 nm) wavelength for 20 min. Post-treatment Quantificare analysis was performed at 15 and 30 days after treatment.…”