Exosomes in ischemic heart disease: novel carriers for bioinformation

Zhou, Huan; Wang, Bin; Yang, Yingxi; Jia, Qiujin; Qi, Zhongwen; Zhang, Ao; Lv, Shichao; Zhang, Junping

doi:10.1016/j.biopha.2019.109451

Cited by 24 publications

(17 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The exosomal payload plays a significant role in the pathophysiology of IHD including endothelial cell function, lipid deposition and plaque formation, and ischemia-reperfusion injury by constituting an integral part of the intercellular communication. These exosomes are released by a diverse population of cells including endothelial cells, cardiomyocytes, and smooth muscle cells which are participating in the disease process as shown in Table 1 [134,135]. The exosomal miRs released by these cells, as well as by the inflammatory cells homing-in to injured myocardium, also play a significant role in the acute phase inflammatory response as part of the intrinsic repair process in the heart [134].…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

“…These exosomes are released by a diverse population of cells including endothelial cells, cardiomyocytes, and smooth muscle cells which are participating in the disease process as shown in Table 1 [134,135]. The exosomal miRs released by these cells, as well as by the inflammatory cells homing-in to injured myocardium, also play a significant role in the acute phase inflammatory response as part of the intrinsic repair process in the heart [134]. This necessitates in-depth future studies to develop protocols to ensure that the exogenously delivered exosomes could deliver their miR payload without getting eliminated from the site of injury by the inflammatory cells.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy

2020

View full text Add to dashboard Cite

Bone marrow-derived mesenchymal stem cells (MSCs) have successfully progressed to phase III clinical trials successive to an intensive in vitro and pre-clinical assessment in experimental animal models of ischemic myocardial injury. With scanty evidence regarding their cardiogenic differentiation in the recipient patients' hearts post-engraftment, paracrine secretion of bioactive molecules is being accepted as the most probable underlying mechanism to interpret the beneficial effects of cell therapy. Secretion of small non-coding microRNA (miR) constitutes an integral part of the paracrine activity of stem cells, and there is emerging interest in miRs' delivery to the heart as part of cell-free therapy to exploit their integral role in various cellular processes. MSCs also release membrane vesicles of diverse sizes loaded with a wide array of miRs as part of their paracrine secretions primarily for intercellular communication and to shuttle genetic material. Exosomes can also be loaded with miRs of interest for delivery to the organs of interest including the heart, and hence, exosome-based cell-free therapy is being assessed for cell-free therapy as an alternative to cell-based therapy. This review of literature provides an update on cell-free therapy with primary focus on exosomes derived from BM-derived MSCs for myocardial repair.

show abstract

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy

2020

View full text Add to dashboard Cite

show abstract

“…Subsequently, exosome release following exercise can carry exerkines that might modulate intercellular communication (Safdar and Tarnopolsky, 2018). Several papers have suggested that these might modulate aging (Bertoldi et al, 2018) , T2DM ll Cell Metabolism 33, September 7, 2021 1753 Review (Li et al, 2019b;Safdar et al, 2016), cardiovascular diseases (CVDs) (Bei et al, 2017;Zhou et al, 2019;Ma et al, 2018), immunity (Lancaster and Febbraio, 2005;Wu and Liu, 2018), and sarcopenia (Rong et al, 2020).…”

Section: Skeletal Muscle Exosomesmentioning

confidence: 99%

Exosomes as mediators of intercellular crosstalk in metabolism

et al. 2021

View full text Add to dashboard Cite

“…These particles, bound by a lipid bi-layer, are produced and released by most cell types and can be broadly divided into three classes depending on their biogenesis: exosomes, microvesicles and apoptotic bodies (Van Niel et al 2018 ; Caruso and Poon 2018 ). EVs have been isolated from pericardial fluid from patients undergoing cardiac surgery (Kuosmanen et al 2015 ; Beltrami et al 2017 ) and have been implicated in the progression of cardiovascular disease (Wang et al 2014 ; Emanueli et al 2015 ), but are also thought to have roles in mediating cell–cell communication between different cell types within the heart, including CMs, fibroblasts and immune cells (Bang et al 2014 , 2015 ; Todorova et al 2017 ; Zhou et al 2019 ). Further to this, there is emerging data that suggest there may be EV populations that are cardioprotective and promote angiogenesis (Emanueli et al 2015 ; Todorova et al 2017 ; Zhou et al 2019 ).…”

Section: Extracellular Vesicles Cilia and Signalling Networkmentioning

confidence: 99%

Zebrafish cardiac regeneration—looking beyond cardiomyocytes to a complex microenvironment

Ryan

Moyse

Richardson

2020

Histochem Cell Biol

View full text Add to dashboard Cite

The study of heart repair post-myocardial infarction has historically focused on the importance of cardiomyocyte proliferation as the major factor limiting adult mammalian heart regeneration. However, there is mounting evidence that a narrow focus on this one cell type discounts the importance of a complex cascade of cell–cell communication involving a whole host of different cell types. A major difficulty in the study of heart regeneration is the rarity of this process in adult animals, meaning a mammalian template for how this can be achieved is lacking. Here, we review the adult zebrafish as an ideal and unique model in which to study the underlying mechanisms and cell types required to attain complete heart regeneration following cardiac injury. We provide an introduction to the role of the cardiac microenvironment in the complex regenerative process and discuss some of the key advances using this in vivo vertebrate model that have recently increased our understanding of the vital roles of multiple different cell types. Due to the sheer number of exciting studies describing new and unexpected roles for inflammatory cell populations in cardiac regeneration, this review will pay particular attention to these important microenvironment participants.

show abstract

Exosomes in ischemic heart disease: novel carriers for bioinformation

Cited by 24 publications

References 83 publications

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy

Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy

Exosomes as mediators of intercellular crosstalk in metabolism

Zebrafish cardiac regeneration—looking beyond cardiomyocytes to a complex microenvironment

Contact Info

Product

Resources

About