Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Tang, Qiaomei; Lu, Bing; He, Jian; Chen, Xiao; Fu, Qiang; Han, Heyou; Luo, Chenqi; Yin, Houfa; Qin, Zhenwei; Lyu, Danni; Zhang, Lifang; Zhou, Min; Yao, Ke

doi:10.1016/j.biomaterials.2021.121320

Cited by 146 publications

(100 citation statements)

References 43 publications

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“…EVs from embryonic mesenchymal stem cells alleviate osteoarthritis ( Wang et al, 2017 ), mediate cartilage repair ( Zhang et al, 2018 ), inhibit cell death ( Tavakoli Dargani and Singla, 2019 ), enhance cardiac function after myocardial infarction ( Khan et al, 2015 ), and promote pressure ulcer healing ( Chen et al, 2019 ). EVs from induced pluripotent stem cells can improve myocardial infarction ( Gao et al, 2020 ), accelerate skin cell proliferation ( Kim et al, 2018 ), promote corneal epithelial hyperplasia ( Tang et al, 2022 ), and resist osteoporosis ( Cui et al, 2022 ). Similarly, EVs derived from MSCs have also been extensively studied.…”

Section: Discussionmentioning

confidence: 99%

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Lin

Yang

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Objective: With the development of extracellular vesicles (EVs) based on stem cells research all over the world, our present study was aiming to discover the global trends in this field.Methods: All publications related to EVs based on stem cells from 1991 to 2021 were collected from the Science Citation Index-Expanded of Web of Science Subsequently, the data were evaluated using the bibliometric methodology. In terms of visualized study, the VOS viewer software was performed to investigate the bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, and last for the publication’s trends involved in the field of EVs based on stem cells.Results: A total of 8,208 publications were retrieved and the relative number of global publications and research interests were increasing every year especially in recent 5 years. China rank top one in terms of total publications, prolific authors, and funds, whereas the USA made the greatest contributions with the most total citations and highest H-index to the global research. Stem cell research therapy contributed the highest publications, whereas the journal of PLOS ONE showed the best total link strength. The Shanghai Jiao Tong University, University of California System, and Harvard University were the most contributive institutions. The global studies could be divided into six clusters as follows: cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, and cardiovascular system research. All the directions were predicted to still hotspots in near future researches in this field.Conclusion: The total number of publications about EVs based stem cells would be increasing according to the current global trends. China and the USA was the largest contributors in this field. Further efforts should be put in the directions of cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, as well was cardiovascular system research in this field of EVs based stem cells.

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Section: Discussionmentioning

confidence: 99%

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Lin

Yang

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Conversely, changes in the ECM affect cellular proliferation, migration, and organ morphogenesis. For example, exosomes can promote ECM synthesis by regulating matrix metalloproteinases (MMPs) [ 94 ], whereas some exosomes can inhibit the deposition of the ECM by suppressing collagen biosynthesis [ 95 ]. Exosomes as regulators of the immune response.…”

Section: Exosomesmentioning

confidence: 99%

“…The dynamic coordination of adipose stem cell-derived exosomes and PEG hydrogels via Ag + –S resulted in outstanding injectable, self-healing, and antibacterial properties for endometrial and fertility restoration [ 113 ]. To effectively promote the repair of corneal damage, exosomes derived from MSCs were loaded in thermosensitive chitosan-based hydrogels [ 95 ].…”

Section: Biomedical Exploitation Of Exosomes Delivered In Hydrogelsmentioning

confidence: 99%

Hydrogels for Exosome Delivery in Biomedical Applications

Xie

Guan

Guo

et al. 2022

Gels

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Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological and biomedical applications, such as for drug delivery, tissue engineering, and models for medical studies, have been made. Due to their similarity in physiological structure, hydrogels are highly compatible with extracellular matrices and biological tissues and can be used as both carriers and matrices to encapsulate cellular secretions. As small extracellular vesicles secreted by nearly all mammalian cells to mediate cell–cell interactions, exosomes play very important roles in therapeutic approaches and disease diagnosis. To maintain their biological activity and achieve controlled release, a strategy that embeds exosomes in hydrogels as a composite system has been focused on in recent studies. Therefore, this review aims to provide a thorough overview of the use of composite hydrogels for embedding exosomes in medical applications, including the resources for making hydrogels and the properties of hydrogels, and strategies for their combination with exosomes.

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“…Nowadays, synthetic or allogenic implants are the most widely used options for their treatment, but adverse effects such as high rejection rates frequently occur, and the shortage of donors generates long waiting lists. In the search for alternatives, chitosan has emerged as a good option [149,150].…”

Section: Cornea Damagementioning

confidence: 99%

Applications of Chitosan in Surgical and Post-Surgical Materials

et al. 2022

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The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, chitosan is a promising material for the development of formulations and devices with surgical applications due to its intrinsic bacteriostatic, fungistatic, hemostatic, and analgesic properties. A wide range of products has been manufactured with this polymer, including scaffolds, sponges, hydrogels, meshes, membranes, sutures, fibers, and nanoparticles. The growing interest of researchers in the use of chitosan-based materials for tissue regeneration is obvious due to extensive research in the application of chitosan for the regeneration of bone, nervous tissue, cartilage, and soft tissues. Chitosan can serve as a substance for the administration of cell-growth promoters, as well as a support for cellular growth. Another interesting application of chitosan is hemostasis control, with remarkable results in studies comparing the use of chitosan-based dressings with traditional cotton gauzes. In addition, chitosan-based or chitosan-coated surgical materials provide the formulation with antimicrobial activity that has been highly appreciated not only in dressings but also for surgical sutures or meshes.

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Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Cited by 146 publications

References 43 publications

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Hydrogels for Exosome Delivery in Biomedical Applications

Applications of Chitosan in Surgical and Post-Surgical Materials

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