Exosomes: New regulators of reproductive development

Chen, Chang; Zhang, Zhenhao; Gu, Xing; Sheng, Xihui; Xiao, Longfei; Wang, Xiangguo

doi:10.1016/j.mtbio.2023.100608

Cited by 21 publications

(11 citation statements)

References 149 publications

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“…This fluid will become a nutrient for the ovum from maturation until implanted in the uterus. 22 Figure 1 shows the histological structure of the primary, secondary, De Graafian and corpus luteum follicles after administering Sunkai extract for the treatment duration. The increase in ovulation rate is very effective in improving the fertility rate of experimental animals.…”

Section: Resultsmentioning

confidence: 99%

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

2023

TJNPR

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Sungkai leaf (Peronema canescens Jack.) is a natural source of flavonoids. Flavonoids have been implicated in increasing fertility in humans. This study aims to determine the effect of oral ethanol extract of Sungkai leaf on the fertility of female mice. Twenty-four female mice randomly divided into four groups were used in this study. The test (II-IV) groups were administered orally ethanol leaf extract of Peronema canescens at doses of 200 mg/kg bw, 400 mg/kg bw, and 800 mg/kg bw, respectively, for 14 days. The negative control (I) group received 0.5% Na-CMC only. On the 15th day, the mice were mated with male mice in one cage until pregnancy was established. On the 10th day of gestation, the mice were sacrificed by cervical dislocation, and both ovaries were excised. The result shows increased primary ovarian follicles, corpus luteum, and ovulation rate. The optimal increase of the ovaries occurred at the dose of 200 mg/kg bw. There was however a decrease in the above parameters at extract doses of 400 and 800 200 mg/kg bw. The study concludes that the leaf extract of Peronema canescens has the potential to treat infertility.

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Section: Resultsmentioning

confidence: 99%

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

2023

TJNPR

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“…1 ). Among these, ultrahigh-speed centrifugation is the most commonly used method of exosome isolation [ 21 ]. There are multiple techniques available to extract exosomes.…”

Section: Preparation Of Exosomesmentioning

confidence: 99%

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

Yu,

Yang,

Zhou

et al. 2024

Stem Cell Res Ther

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Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primary and secondary injury, and secondary injury is a cascade of amplified responses triggered by the primary injury. Due to the complexity of the pathological mechanisms of SCI, there is no clear and effective treatment strategy in clinical practice. Exosomes, which are extracellular vesicles of endoplasmic origin with a diameter of 30–150 nm, play a critical role in intercellular communication and have become an ideal vehicle for drug delivery. A growing body of evidence suggests that exosomes have great potential for repairing SCI. In this review, we introduce exosome preparation, functions, and administration routes. In addition, we summarize the effect and mechanism by which various exosomes repair SCI and review the efficacy of exosomes in combination with other strategies to repair SCI. Finally, the challenges and prospects of the use of exosomes to repair SCI are described.

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“…miRNAs are also involved in regulating the sperm-oocyte binding like miR-34c affect the expression of the ion channel protein CatSper, which is required for sperm-oocyte fusion (Kathirvel et al, 2013). Similarly, miR-199a-5p has been shown to regulate the expression of the membrane protein CD9, which is also required for sperm-egg fusion (Chen et al, 2023).…”

Section: Mirna In Fertilizationmentioning

confidence: 99%

Role of MicroRNAs in Mammalian Reproduction

Shavi,

Saini,

Gupta

et al. 2023

Anim. Reprod. Update

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MicroRNAs are small, endogenous, non-coding RNA molecules that are around 19-25 nucleotides long. Most miRNAs are produced via transcription of DNA sequences into primary miRNAs, precursor miRNAs, and then mature miRNAs. These miRNA molecules base-pair to mRNAs to control gene expression post-transcriptionally. Mammalian genome now has over 2000 annotated miRNAs which are thought to influence one-third of the genes in the genome since each miRNA can regulate hundreds of target genes. miRNAs are involved in morphogenesis, tissue maintenance, cell development, differentiation, apoptosis, and metabolism etc. This review aims to summarize the current understanding of the role of miRNAs in various stages of mammalian reproductive biology and their involvement in reproductive disorders. We have also summarized the recent advances about miRNA and provide an updated overview of the literature, including the most recent and relevant studies.

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Exosomes: New regulators of reproductive development

Cited by 21 publications

References 149 publications

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy

Role of MicroRNAs in Mammalian Reproduction

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