Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression

Ye, Leiguang; Li, Yingpu; Zhang, Sifan; Lei, Bo

doi:10.1016/j.cytogfr.2023.05.002

Cited by 22 publications

(4 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lipid metabolism includes lipogenesis, lipid uptake, fatty acid oxidation, and lipolysis. Previously, much attention has been paid on the role of lipid metabolism in regulation of exosome biogenesis; however, exosomes-regulated lipid metabolism in tumorigenesis and cancer progression are emerging in recent years [ 162 ]. The expression of HBV pre-S2 trans-regulated protein 3 (HSPC111) was elevated in CRC cells with highly metastatic potential [ 163 ].…”

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Wu,

Cao,

Chen

et al. 2024

Biol Proced Online

View full text Add to dashboard Cite

Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment. After secretion, the exosomes carrying a wide range of bioactive cargos can be ingested by local or distant recipient cells. The released cargos act through a variety of mechanisms to elicit multiple biological effects and impact most if not all hallmarks of cancer. Moreover, owing to their excellent biocompatibility and capability of being easily engineered or modified, exosomes are currently exploited as a promising platform for cancer targeted therapy. In this review, we first summarize the current knowledge of roles of exosomes in risk and etiology, initiation and progression of cancer, as well as their underlying molecular mechanisms. The aptamer-modified exosome as a promising platform for cancer targeted therapy is then briefly introduced. We also discuss the future directions for emerging roles of exosome in tumor biology and perspective of aptamer-modified exosomes in cancer therapy.

show abstract

Section: Tumor Biology Of Exosomesmentioning

confidence: 99%

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Wu,

Cao,

Chen

et al. 2024

Biol Proced Online

View full text Add to dashboard Cite

show abstract

“…It has been discovered that exosomes play important roles in many biological processes, including the presentation of antigen, angiogenesis, and intercellular signal transduction. On the one hand, exosomes can promote epithelial-mesenchymal transition (EMT) of tumor cells ( Bhattacharya et al, 2023 ), induce angiogenesis ( Jiang et al, 2022 ), mediate immune escape, regulate macrophage polarization and lipid metabolism to promote tumor development ( Ye et al, 2023 ). For example, LncRNA BCRT1 can promote M2 polarization of macrophages, promote tumor migration and chemotactic ability, and thus promote tumor progression ( Ye et al, 2023 ).…”

Section: Overview Of Exosome Functions and Applicationsmentioning

confidence: 99%

“…On the one hand, exosomes can promote epithelial-mesenchymal transition (EMT) of tumor cells ( Bhattacharya et al, 2023 ), induce angiogenesis ( Jiang et al, 2022 ), mediate immune escape, regulate macrophage polarization and lipid metabolism to promote tumor development ( Ye et al, 2023 ). For example, LncRNA BCRT1 can promote M2 polarization of macrophages, promote tumor migration and chemotactic ability, and thus promote tumor progression ( Ye et al, 2023 ). On the other hand, different cells carry different antigens, which affect the anti-tumor functions of immune cells such as DC cells, T cells, macrophages and so on ( Zhang and Yu, 2019 ).…”

Section: Overview Of Exosome Functions and Applicationsmentioning

confidence: 99%

Application of exosomes in tumor immunity: recent progresses

Qiu,

Liang,

Yang

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role in intercellular communication and material transfer. In tumor immunity, exosomes present various functions while the following two are of great importance: regulating the immune response and serving as delivery carriers. This review starts with the introduction of the formation, compositions, functions, isolation, characterization, and applications of exosomes, and subsequently discusses the current status of exosomes in tumor immunotherapy, and the recent applications of exosome-based tumor immunity regulation and antitumor drug delivery. Finally, current challenge and future prospects are proposed and hope to demonstrate inspiration for targeted readers in the field.

show abstract

“…These results suggest that exosome-carrying circRNAs are useful for cellular communication between multiple cell types in TME. Besides glycolysis, tumor metabolic reprogramming also includes lipid and amino acid metabolism, and exosomes are involved in these metabolic processes ( 83 , 84 ). However, the processes by which exosomal circRNAs of hepatocellular carcinoma secreted are involved in these metabolic reprogramming remain unclear and need to be further elucidated.…”

Section: Hcc-derived Exosomal Circrnas Remodel the Tmementioning

confidence: 99%

An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment

Xu,

Lin,

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC), the most common primary malignancy of the liver, is one of the leading causes of cancer-related death and is associated with a poor prognosis. The tumor microenvironment (TME) of HCC comprises immune, immunosuppressive, and interstitial cells with hypoxic, angiogenic, metabolic reprogramming, inflammatory, and immunosuppressive features. Exosomes are nanoscale extracellular vesicles that secrete biologically active signaling molecules such as deoxyribonucleic acid (DNA), messenger ribonucleic acid (mRNA), microribonucleic acid (miRNA), proteins, and lipids. These signaling molecules act as messengers in the tumor microenvironment, especially the tumor immunosuppressive microenvironment. Exosomal circRNAs reshape the tumor microenvironment by prompting hypoxic stress response, stimulating angiogenesis, contributing to metabolic reprogramming, facilitating inflammatory changes in the HCC cells and inducing tumor immunosuppression. The exosomes secreted by HCC cells carry circRNA into immune cells, which intervene in the activation of immune cells and promote the overexpression of immune checkpoints to regulate immune response, leading tumor cells to acquire immunosuppressive properties. Furthermore, immunosuppression is the final result of a combination of TME-related factors, including hypoxia, angiogenesis, metabolic reprogramming, and inflammation changes. In conclusion, exosomal circRNA accelerates the tumor progression by adjusting the phenotype of the tumor microenvironment and ultimately forming an immunosuppressive microenvironment. HCC-derived exosomal circRNA can affect HCC cell proliferation, invasion, metastasis, and induction of chemoresistance. Therefore, this review aimed to summarize the composition and function of these exosomes, the role that HCC-derived exosomal circRNAs play in microenvironment formation, and the interactions between exosomes and immune cells. This review outlines the role of exosomal circRNAs in the malignant phenotype of HCC and provides a preliminary exploration of the clinical utility of exosomal circRNAs.

show abstract

Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression

Cited by 22 publications

References 158 publications

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy

Application of exosomes in tumor immunity: recent progresses

An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment

Contact Info

Product

Resources

About