Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion

Ying, Xiaofang; Jin, Xiaoxiao; Zhu, Ying; Liang, Meili; Chang, Xinwen; Zheng, Lingzhi

doi:10.1016/j.intimp.2020.106981

Cited by 26 publications

(15 citation statements)

References 29 publications

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“…The RNA molecules enclosed in Mφ-EVs comprise mainly mRNA (intact mRNA and mRNA fragments) ( 31 , 43 ), miRNA ( 60 ), long non-coding RNA ( 46 ), and tRNA ( 1 ). Lee et al obtained EVs from Mφ treated with Shiga toxin 2a toxoids and found that they express higher levels of mRNAs encoding the pro-inflammatory cytokines IL-1β and IL-8, thereby exacerbating inflammation ( 9 ).…”

Section: Mφ-evsmentioning

confidence: 99%

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

et al. 2021

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As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control communication among cells. Under physiological and pathological conditions, EVs deliver generic information including proteins and nucleic acids to recipient cells and exert regulatory effects. Macrophages help mediate immune responses, and macrophage-derived EVs may play immunomodulatory roles in the progression of chronic inflammatory diseases. Furthermore, EVs derived from various macrophage phenotypes have different biological functions. In this review, we describe the pathophysiological significance of macrophage-derived extracellular vesicles in the development of chronic inflammatory diseases, including diabetes, cancer, cardiovascular disease, pulmonary disease, and gastrointestinal disease, and the potential applications of these EVs.

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Section: Mφ-evsmentioning

confidence: 99%

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

et al. 2021

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“…EVs exert biological functions mainly through the biologically molecules they conduct. For example, EVs released from DMs could deliver miR-153-3p to target IDO, inhibiting trophoblasts proliferation and migration via STAT3 pathway and contributing to occurrence of unexplained RSA ( 103 ). Recently, our group reported that EVs derived from M1-Mφ could deliver miR-146a-5p and miR-146b-5p to target TNF receptor associated factor 6 (TRAF6), suppressing trophoblast migration and invasion and contributing to the development of RSA ( 104 ).…”

Section: The Role Of Extracellular Vesicles In Crosstalk Between Macrophages and Trophoblasts At The Maternal-fetal Interfacementioning

confidence: 99%

Crosstalk Between Trophoblast and Macrophage at the Maternal-Fetal Interface: Current Status and Future Perspectives

et al. 2021

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The immune tolerance microenvironment is crucial for the establishment and maintenance of pregnancy at the maternal-fetal interface. The maternal-fetal interface is a complex system containing various cells, including lymphocytes, decidual stromal cells, and trophoblasts. Macrophages are the second-largest leukocytes at the maternal-fetal interface, which has been demonstrated to play essential roles in remodeling spiral arteries, maintaining maternal-fetal immune tolerance, and regulating trophoblast’s biological behaviors. Many researchers, including us, have conducted a series of studies on the crosstalk between macrophages and trophoblasts at the maternal-fetal interface: on the one hand, macrophages can affect the invasion and migration of trophoblasts; on the other hand, trophoblasts can regulate macrophage polarization and influence the state of the maternal-fetal immune microenvironment. In this review, we systemically introduce the functions of macrophages and trophoblasts and the cell-cell interaction between them for the establishment and maintenance of pregnancy. Advances in this area will further accelerate the basic research and clinical translation of reproductive medicine.

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“…Regulatory miRNAs in trophoblast cells also contribute to their proliferation, migration, and invasion (such as miR-210 [ 91 ], miR-126-3p [ 92 ], and miR-23a [ 93 ]) during pregnancy. Of note, exosomes play crucial roles in the mediation of cell-to-cell communication at maternal-fetal interface [ 94 , 95 ], and it is worth exploring that whether above functional miRNAs can be transferred into dNK cells by ESCs/trophoblasts-derived exosomes in pregnancy related disorders, inducing dysfunctions of dNK cells and impairing immune system balance of pregnant women. In turn, NK cell-derived exosomes are identified to mediate cytotoxicity against tumor cells [ 96 , 97 ], and it is not known whether dNK cell can secrete miRNA-containing exosomes or micro-vesicles into maternal-fetal interface, which can affect systemic inflammation, decidualization and biological behavior of other decidual cells.…”

Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

miRNAs in decidual NK cells: regulators worthy of attention during pregnancy

Feng

Zhou

et al. 2021

Reprod Biol Endocrinol

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The critical immune effectors, including T, B, and natural killer (NK) cells, dendritic cells, and macrophages participate in regulating immune responses during pregnancy. Among these immune cells, decidual NK (dNK) cells are involved in key placental development processes at the maternal–fetal interface, such as uterine spiral artery remodeling, trophoblast invasion, and decidualization. Mechanistically, dNK cells significantly influence pregnancy outcome by secreting cytokines, chemokines, and angiogenic mediators and by their interactions with trophoblasts and other decidual cells. MicroRNAs (miRNAs) are small non-coding RNA molecules that participate in the initiation and progression of human diseases. Although the functions of circulating miRNAs in pathological mechanism has been extensively studied, the regulatory roles of miRNAs in NK cells, especially in dNK cells, have been rarely reported. In this review, we analyze the effects of miRNA regulations of dNK cell functions on the immune system during gestation. We discuss aberrant expressions of certain miRNAs in dNK cells that may lead to pathological consequences, such as recurrent pregnancy loss (RPL). Interestingly, miRNA expression patterns are also different between dNK cells and peripheral NK (pNK) cells, and pNK cells in the first- and third‐trimester of gestation. The dysregulation of miRNA plays a pivotal regulatory role in driving immune functions of dNK and pNK cells. Further understanding of the molecular mechanisms of miRNAs in dNK cells may provide new insights into the development of therapeutics to prevent pregnancy failure.

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Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion

Cited by 26 publications

References 29 publications

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

Crosstalk Between Trophoblast and Macrophage at the Maternal-Fetal Interface: Current Status and Future Perspectives

miRNAs in decidual NK cells: regulators worthy of attention during pregnancy

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