Exothermic effect of dextran-coated Fe3O4 magnetic fluid and its compatibility with blood

Liu, G.; Hong, Ruoyu; Guo, Liang; Liu, G.H.; Feng, Bin; Li, Y.G.

doi:10.1016/j.colsurfa.2011.03.006

Cited by 16 publications

(5 citation statements)

References 30 publications

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“…However, visual observation proves that BRCs do not coagulate, for example, at 0.32 mg/mL magnetite content (left side of Figure 8). Blood coagulation experiments have also been conducted by Liu and co-workers 62 (using dextran-coated MNPs), and they found the same level of resistance against similar magnetite concentrations as in our experiments.…”

Section: ■ Results and Discussionsupporting

confidence: 86%

Designed Polyelectrolyte Shell on Magnetite Nanocore for Dilution-Resistant Biocompatible Magnetic Fluids

et al. 2012

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Magnetite nanoparticles (MNPs) coated with poly(acrylic acid-co-maleic acid) polyelectrolyte (PAM) have been prepared with the aim of improving colloidal stability of core-shell nanoparticles for biomedical applications and enhancing the durability of the coating shells. FTIR-ATR measurements reveal two types of interaction of PAM with MNPs: hydrogen bonding and innersphere metal-carboxylate complex formation. The mechanism of the latter is ligand exchange between uncharged -OH groups of the surface and -COO -anionic moieties of the polyelectrolyte as revealed by adsorption and electrokinetic experiments. The aqueous dispersion of PAM@MNP particles (magnetic fluids -MFs) tolerate physiological salt concentration at composition corresponding to the plateau of the high-affinity adsorption isotherm. The plateau is reached at small amount of added PAM and at low concentration of non-adsorbed PAM, making PAM highly efficient for coating MNPs. The adsorbed PAM layer is not desorbed during dilution. The performance of the PAM shell is superior to that of polyacrylic acid (PAA), often used in biocompatible MFs. This is explained by the different adsorption mechanisms, namely metalcarboxylate cannot form in the case of PAA. Molecular-level understanding of the protective shell formation on MNPs presented here improves fundamentally the colloidal techniques used in coreshell nanoparticle production for nanotechnology applications. This is a PDF file of an unedited manuscript that has been accepted for publication. Final edited form is published in Langmuir 2012, 28, 16638−16646. http://dx

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Section: ■ Results and Discussionsupporting

confidence: 86%

Designed Polyelectrolyte Shell on Magnetite Nanocore for Dilution-Resistant Biocompatible Magnetic Fluids

et al. 2012

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“…Our group has conducted research on the heating effect of Fe 3 O 4 magnetic fluid; the results demonstrated that the exothermic ability of magnetic fluid was excellent in an alternating magnetic field. 28 Magnetic fluid can be used for magnetic induction heating treatment of a tumor, one of the crucial factors is that the temperature used for cancer therapy should reach 44–47℃. In this section, the in vitro heating effect of the modified magnetic nanoparticles was evaluated systematically.…”

Section: Resultsmentioning

confidence: 99%

RGD-conjugated iron oxide magnetic nanoparticles for magnetic resonance imaging contrast enhancement and hyperthermia

Huang

et al. 2013

J Biomater Appl

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The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-aspartic peptides for integrin α(v)β₃ targeting. The particle size, magnetic properties, heating effect, and stability of the arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide were measured. The arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide demonstrates excellent stability and fast magneto-temperature response. Magnetic resonance imaging signal intensity of Bcap37 cells incubated with arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide was significantly decreased compared with that incubated with plain ultrasmall superparamagnetic iron oxide. The preferential uptake of arginine-glycine-aspartic-ultrasmall superparamagnetic iron oxide by target cells was further confirmed by Prussian blue staining and confocal laser scanning microscopy.

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“…To resolve this challenge, polymeric and inorganic nanoparticles, liposomes, micelles and phospholipid complexes have been used to encapsulate them for delivery. Among them, polymeric nanoparticles are emerging as one of the best options due to their higher stability (Cole et al 2011a ; Lin et al 2012 ; Liu et al 2011 ; Rao et al 2013 ). The particles can be delivered to the tumor either passively thorough vascularization and the enhanced permeation and retention effect (EPR) or actively thorough receptor-mediated endocytosis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

et al. 2017

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Cancer treatment has been very challenging in recent decades. One of the most promising cancer treatment methods is hyperthermia, which increases the tumor temperature (41–45 °C). Magnetic nanoparticles have been widely used for selective targeting of cancer cells. In the present study, magnetic dextran-spermine nanoparticles, conjugated with Anti-HER2 antibody to target breast cancer cells were developed. The magnetic dextran-spermine nanoparticles (DMNPs) were prepared by ionic gelation, followed by conjugation of antibody to them using EDC-NHS method. Then the Prussian blue method was used to estimate the targeting ability and cellular uptake. Cytotoxicity assay by MTT showed that antibody-conjugated MNPs (ADMNPs) have no toxic effect on SKBR3 and human fibroblast cells. Finally, the hyperthermia was applied to show that synthesized ADMNPs, could increase the cancer cells temperature up to 45 °C and kill most of them without affecting normal cells. These observations proved that Anti-HER2 conjugated magnetic dextran-spermine nanoparticles can target and destroy cancer cells and are potentially suitable for cancer treatment.

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Exothermic effect of dextran-coated Fe3O4 magnetic fluid and its compatibility with blood

Cited by 16 publications

References 30 publications

Designed Polyelectrolyte Shell on Magnetite Nanocore for Dilution-Resistant Biocompatible Magnetic Fluids

Designed Polyelectrolyte Shell on Magnetite Nanocore for Dilution-Resistant Biocompatible Magnetic Fluids

RGD-conjugated iron oxide magnetic nanoparticles for magnetic resonance imaging contrast enhancement and hyperthermia

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

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