Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation

Abstract

Oil-in-water nanoemulsions are stable systems with droplet sizes in the 20-200 nm range. The physicochemical properties of these systems may be influenced by the addition of additives. Thus, the influence of ethoxylated (EL) and acetylated lanolin (AL) addition on the droplet size, pH values, electrical conductivity and stability of nanoemulsions was investigated. Then, effect of nano-emulsions additives with EL (NE-EL) or AL (NE-AL) in hydration, oiliness and pH of the skin were evaluated. Nanoemulsion safety was evaluated through the observation of no undesirable effects after skin formulation application. Both additives caused changes in droplet size and electrical conductivity, but not in pH values. Nanoemulsions containing up to 6.0% ethoxylated lanolin and 2.0% acetylated lanolin remained stable after centrifugation tests. Higher concentrations of the additives made the nanoemulsions unstable. Stability tests showed that ethoxylated lanolin produced more stable nanoemulsions then acetylated lanolin and that the major instability phenomenon occurring in these systems is coalescence at elevated temperatures. Nanoemulsion-based lanolin derivatives increased skin hydration and oiliness and did not change cutaneous pH values. These formulations are non-toxic since they did not cause any irritation on the skin surface after nanoemulsion application, showing potential as carriers for pharmaceuticals and cosmetic applications.

Formulation, Characterization and Properties of Hemp Seed Oil and Its Emulsions

“…Recently, exotic vegetable oil-in-water nanoemulsions with the addition of ethoxylated and acetylated lanolin have been obtained by using a low energy EIP method. It has been shown that the lanolin derivative addition caused alterations of droplet size and conductivity of the systems, however the droplet size remained still within the nanometer range (20–200 nm) [ 26 ]. Lane et al [ 27 ] reported on flaxseed and algae nanoemulsions formulated with combinations of Tween 40 and lecithin.…”

Nanocosmetics: Production, Characterization, and Performance Improvement

“…In addition, methodologies such as atomic force microscopy [19,27], transmission electron microscopy [12,22,27,30], scanning electron microscopy [8,20,23], and optical microscopy [9,20] have been used as way to complement size determination and to evaluate particle morphology. Moreover, pH measurement of nanocarriers [25,30,33,34] allows assessing the compatibility of the skin to the nanocarrier.…”

Oils from fruit seeds and their dietetic and cosmetic significance

“…It was confirmed that raspberry seed oil can be a well-tolerated base for cosmetics and dermocosmetics, not causing skin irritation. Research by Pereira et al [25] shows that the nano-emulsion based in plant oils (raspberry, passion fruit and peach oil) positively influences the condition of the skin, improves hydration and lubrication, without changing the pH value of the skin [24]. Oomah et al [23] report that raspberry seed oil has the ability to absorb UV radiation, thus it can be used and consequently a deficiency in the body of these acids (ω-3).…”

“…Niculae et al [26] state that this oil can be used to prepare modern forms of cosmetics. It proved to be a valuable component, improving the antioxidative and photoprotective activity of the product [25]. Due to its anti-inflammatory properties, raspberry seed oil has also found applications in cosmetic and pharmaceutical preparations used to prevent gingivitis, eczema and other skin disorders [22].…”