Expanded Efficacy of Venovenous Extracorporeal Membrane Oxygenation Support for Deceased Donor Liver Transplantation

Park, Soon Ji; Park, Ju Yeon; Ri, Hyun-Su; Chung, Minwoo; Ryu, Je Ho; Lee, Tae Beom; Yoon, Ji-Uk

doi:10.1016/j.transproceed.2021.02.021

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Initially an intervention most often utilized in non-adult populations, this advanced emergent life-saving support has increasingly been employed following the benefits demonstrated in the Conventional Ventilator Support versus Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure (CESAR) study [ 3 ], and has seen continued supporting evidence in acute respiratory disorders [ 4 ], as a bridge to heart transplant or a durable MCS device [ 5 , 6 ], or following cardiac arrest and cardiogenic shock [ 7 , 8 ]. It has also shown promise as a method to improve hypoxic-related outcomes during liver transplantation [ 9 ].…”

Section: Ecmo Backgroundmentioning

confidence: 99%

The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics

Peitz

Murry

2023

Antibiotics

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Extracorporeal membrane oxygenation (ECMO) is becoming increasingly utilized to support critically ill patients who experience life-threatening cardiac or pulmonary compromise. The provision of this intervention poses challenges related to its complications and the optimization of medication therapy. ECMO’s mechanical circulatory support is facilitated via various devices and equipment that have been shown to sequester lipophilic- and protein-bound medications, including anti-infectives. Since infectious outcomes are dependent on achieving specific anti-infectives’ pharmacodynamic targets, the understanding of these medications’ pharmacokinetic parameters in the setting of ECMO is important to clinicians. This narrative, non-systematic review evaluated the findings of the most recent and robust pharmacokinetic analyses for commonly utilized anti-infectives in the setting of ECMO. The data from available literature indicates that anti-infective pharmacokinetic parameters are similar to those observed in other non-ECMO critically ill populations, but considerable variability in the findings was observed between patients, thus prompting further evaluation of therapeutic drug monitoring in this complex population.

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Section: Ecmo Backgroundmentioning

confidence: 99%

The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics

Peitz

Murry

2023

Antibiotics

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“…To date, some studies have described the outcomes of ECMO treatment in adult OLT recipients during the peritransplantation period. However, almost all studies were limited to small case series and their short‐term outcomes 15–21. This retrospective study aimed to provide guidance for the early identification of patients who might benefit from ECMO support by characterizing the outcomes of OLT recipients with ECMO treatment at our institution.…”

Section: Introductionmentioning

confidence: 99%

“…However, almost all studies were limited to small case series and their short-term outcomes. [15][16][17][18][19][20][21] This retrospective study aimed to provide guidance for the early identification of patients who might benefit from ECMO support by characterizing the outcomes of OLT recipients with ECMO treatment at our institution.…”

Section: Introductionmentioning

confidence: 99%

Role of extracorporeal membrane oxygenation as a salvage therapy for liver transplantation recipients in a high‐volume transplant center

Yoon

Lim

Lee

et al. 2022

Liver Transplantation

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Extracorporeal membrane oxygenation (ECMO) has been used sporadically in adult orthotopic liver transplantation (OLT) recipients for the treatment of acute cardiopulmonary failure. This retrospective study aimed to identify OLT patients who would benefit from ECMO support. We reviewed 109 OLT patients who received ECMO support for more than 24 h from January 2007 to December 2020. Among the enrolled patients, 15 (13.8%) experienced 18 ECMO‐related complications and 12 (11.0%) experienced ECMO reapplication after weaning during the same hospitalization period. The successful weaning rates were 50.98% in patients who received ECMO support during the peritransplantation period (0–30 days from transplantation) and 51.72% in patients who received ECMO support in the post‐OLT period (more than 30 days after OLT); 24 (47.1%) and 23 (39.7%) patients survived until hospital discharge, respectively. The 109 enrolled OLT recipients who received ECMO support during the perioperative period had a 1‐year survival rate of 42.6%. Multivariate analyses identified the following as significant and independent risk factors for in‐hospital mortality: ECMO treatment prior to 2011 (p = 0.04), septic shock as the indication for ECMO treatment (p = 0.001), and a total bilirubin level of ≥5.0 mg/dl (p = 0.02). The outcomes of adult OLT recipients with ECMO treatment were acceptable in terms of weaning success and survival until hospital discharge. This study confirmed that ECMO treatment for OLT recipients with septic shock and elevated bilirubin levels might be associated with a higher in‐hospital mortality and demonstrated the importance of a multidisciplinary ECMO team approach.

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Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center

Patel,

Gutmann,

Loveridge

et al. 2024

American Journal of Transplantation

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Expanded Efficacy of Venovenous Extracorporeal Membrane Oxygenation Support for Deceased Donor Liver Transplantation

Cited by 4 publications

References 17 publications

The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics

The Influence of Extracorporeal Membrane Oxygenation on Antibiotic Pharmacokinetics

Role of extracorporeal membrane oxygenation as a salvage therapy for liver transplantation recipients in a high‐volume transplant center

Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center

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