Expanded polytetrafluoroethylene conduits and patches with bulging sinuses and fan-shaped valves in right ventricular outflow tract reconstruction: Multicenter study in Japan

Miyazaki, Tatsuya; Yamagishi, Masaaki; Maeda, Yoashinobu; Yamamoto, Yusuke; Taniguchi, Satoshi; Sasaki, Yuji; Yaku, Hitoshi

doi:10.1016/j.jtcvs.2011.08.018

Cited by 92 publications

(73 citation statements)

References 20 publications

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“…Miyazaki and colleagues [20] reported an excellent mid-term outcome of a handmade valved ePTFE conduit with bulging sinuses, in the multicenter study in Japan, with no conduit reoperation in large conduits for 10 years and good conduit valve function [20]. The bulging sinuses represented the shape of sinus of Valsalva and were expected to enhance handmade valve function [15].…”

Section: Commentmentioning

confidence: 99%

Outcome of Right Ventricle to Pulmonary Artery Conduit for Biventricular Repair

Shinkawa

Chipman

Bozzay

et al. 2015

The Annals of Thoracic Surgery

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Section: Commentmentioning

confidence: 99%

Outcome of Right Ventricle to Pulmonary Artery Conduit for Biventricular Repair

Shinkawa

Chipman

Bozzay

et al. 2015

The Annals of Thoracic Surgery

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“…8 Miyazaki et al reported the usefulness of fan-shaped ePTFE valve conduits with bulging sinuses during mid-term follow-up. 17 ePTFE valves should be covered by a thin fibrous tissue and show focal regions of endothelialization. The ePTFE valve cannot be expected to develop adaptive growth during the follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Application of a Fresh Decellularized Pulmonary Allograft for Pulmonary Valve Replacement in Japan

Ozawa

Ueno

Terabe

et al. 2018

Circ J

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Background: Tissue engineering has advanced the technique of decellularization of the heart valve. The valve is reseeded with the patient's own cells after implantation with suppression of immunologic reactions. The same advantage has been reported for fresh decellularized heart valves, and more than 10 years of excellent outcomes have been achieved. We began performing such heart valve implantations in 2013 as part of a clinical study at Osaka University. We report our evaluation of the safety and efficacy of heart valve implantation. Methods and Results:Human pulmonary valves from the German Society for Tissue Transplantation (n=2) or from Japanese heart transplant recipient heart (n=4) were used to make decellularized heart valves; the decellularization process was the same as that used in Europe. Valves were implanted in 5 adults with pulmonary valve insufficiency after tetralogy of Fallot repair and in 1 infant with a double-outlet right ventricle with pulmonary stenosis. Postoperative echocardiography and cardiac magnetic resonance imaging revealed that the valve and ventricular function were significantly improved and maintained postoperatively. Conclusions:Decellularized heart valves could be the new material used as artificial heart valves. Pulmonary allografts derived from the hearts of heart transplant recipients are considered to be useful material for decellularized heart valves. The application of this valve to Japanese clinical circumstances and using the hearts of heart transplant recipients is considered to be very significant.

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“…The benefit of using ePTFE is that it provides a better modulus match than most continuous polymers for many soft biological tissue application [9], easier availability, higher biocompatible and resistance to degeneration or calcification [4]. Recently, ePTFE valved conduits with bulging sinuses of Valsava for RVOT reconstruction has been reported and showed excellent early to mid-term results in patients [10].…”

Section: Introductionmentioning

confidence: 99%

Thermal treatment of expanded polytetraflu-oroethylene (ePTFE) membranes for reconstruction of a valved conduit1

Zhu

Yuan

Yeo

et al. 2015

BME

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Abstract. The unique micro porous structure of expanded polytetrafluoroethylene (ePTFE) that allows bio-integration for fixation, as well as overall mechanical integrity make it used successfully in a number of biomedical and clinical applications, which include the reconstruction of the pulmonary valve in in right ventricular outflow tract reconstruction (RVOT) operations. The objective of this study was to determine the effects of the thermal treatment on physical and mechanical properties of ePTFE membranes. ePTFE sheets were cut into 16 rectangle strips (10 mm by 60 mm) and evenly separated into 4 groups. One group was the blank control (group A), while the rest of the three groups (group B to D) were heated to 350°C and cooled to 24°C at different cooling rates (10°C/min, 20°C/min and rapid ambient air cooling) in a temperature controlled atmosphere. The mechanical and morphological characteristics of all the samples were tested using a tensile test machine and a scanning electron microscopy (SEM). The results show that the elastic modulus of group B to D was 24.95%, 33.45% and 72.76% higher than group A. The percentage elongation of groups B to D was found to be between 2.3% and 40.45 % lower than group A. The proportion of pores in the ePTFE membrane was reduced following the thermal treatment. There were no morphology differences observed between groups B to D. In summary, the selection of cooling rate was important for preserving the mechanical properties of ePTFE membranes under thermal treatment. These findings may provide useful information for the preparation of molded ePTFE valve in RVOT operations.

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Expanded polytetrafluoroethylene conduits and patches with bulging sinuses and fan-shaped valves in right ventricular outflow tract reconstruction: Multicenter study in Japan

Abstract: Fan-shaped ePTFE valved conduits and patches with bulging sinuses have a high freedom from reoperation and prevent pulmonary insufficiency. They represent a promising material for RVOT reconstruction.

Cited by 92 publications

References 20 publications

Outcome of Right Ventricle to Pulmonary Artery Conduit for Biventricular Repair

Outcome of Right Ventricle to Pulmonary Artery Conduit for Biventricular Repair

Application of a Fresh Decellularized Pulmonary Allograft for Pulmonary Valve Replacement in Japan

Thermal treatment of expanded polytetraflu-oroethylene (ePTFE) membranes for reconstruction of a valved conduit1

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