Expanding humanity beyond Earth entails scientific and socioeconomic advancements. Critical to this endeavor is to leverage space to improve terrestrial lives. Since its inception in 2005, the International Space Station United States National Laboratory has spearheaded in-space experimentation, transforming research into intellectual assets and applications on Earth. This paper evaluates the lab's scientific and economic impacts by linking ISS experimental records to scholarly publications and patent inventions. Our findings highlight several key points. First, the volume of experiments on the ISS has steadily increased, with notable contributions from commercial developers and investigators. Growth accelerated in 2012 following NASA's delegation of civilian research management to The Center for the Advancement of Science in Space. From the National Lab, 384 scholarly publications have emerged, predominantly post-2012 and from public sector investigations. However, this growth did not correspond to an increase in patent inventions. We then measured the impact of ISS research with paper and patent citations and applied regression analyses to estimate the variations associated with using the National Lab's facilities. Our results show that ISS papers and patents receive significantly higher citations than their terrestrial counterparts, even when individual scientist-level characteristics are fixed. The difference was disproportionately attributed to experiments developed by public entities, highlighting a fundamental distinction between private and public sciences. Overall, our findings suggest the gradual formation of an ecosystem around the ISS National Lab, which continuously advances scientific knowledge and economic development in space.