Expanding Molecular Diagnostics for Central Nervous System Infections

Gutiérrez, M Oviedo; Emmanuel, Patricia

doi:10.1016/j.yapd.2018.04.005

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…Infections with these types of bacteria can occur and usually follow a breakdown of the mucocutaneous barrier or immunosuppression. Anaerobic meningitis is a rare condition, especially in the adult population, and it appears usually in association with several risk factors such as mastoiditis, acute or chronic otitis media, gastrointestinal disease, craniotomy, abdominal trauma, head or neck tumors, ventricular shunts, bronchogenic carcinoma, peritoneal infections, or the presence of an ignored congenital dermal sinus [ 3 , 4 , 23 , 24 , 25 , 26 ]. Its mortality is usually higher than in other types of acute bacterial meningitis (30.8 vs. 25.5) [ 5 , 27 ]…”

Section: Discussionmentioning

confidence: 99%

“…Polymicrobial meningitis including anaerobes is very rare nowadays, but was reported in the past as a complication in ear–nose–throat (ENT), abdominal, or gynecological infections, or other rare clinical malformations, such as Currarino syndrome (characterized by the triad of sacral anomaly, anorectal malformation, and presacral mass) [ 1 , 2 ]. Of these, otolaryngological infections are a known predisposing factor mainly for anaerobic meningitis [ 3 ]. Chronic suppurative otitis media (CSOM) is a common complication of brain abscess, meningitis, and lateral sinus thrombophlebitis, the prevalence of all intracranial complications being 0.17% and the mean age 5–10 years old, most cases being reported in the pediatric population [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Polymicrobial Bacterial Meningitis in a Patient with Chronic Suppurative Otitis Media: Case Report and Literature Review

Vâţă,

Irimie-Băluţă,

Roşu

et al. 2023

Medicina

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Polymicrobial meningitis is a rare entity in the adult population, especially in the antibiotic era. However, disorders such as chronic suppurative otitis media (CSOM) or even poor oral hygiene are considered risk factors for the development of such cerebral infection. We report a case of polymicrobial meningitis associated with oto-mastoiditis in a 64-year-old female patient known to have CSOM. The patient presented atypical symptoms for community-acquired meningitis, showing subacute evolution of headache, without fever or neck stiffness. The aerobe microorganisms Streptococcus anginosus and Corynebacterium spp., sensitive to beta-lactamines, and the anaerobe Prevotella spp., resistant to penicillin and metronidazole, were isolated from CSF specimens, while Proteus mirabilis and Enterococcus faecalis were identified from the ear drainage. The diversity of pathogens identified in our case led us to the hypothesis of two different sources of meningitis: otogenic and/or odontogenic. Favorable evolution was obtained after a multi-disciplinary approach, combining surgery and broad-spectrum antibiotics. In addition, we performed a literature review that highlights the low incidence of polymicrobial mixed aerobe–anaerobe meningitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymicrobial Bacterial Meningitis in a Patient with Chronic Suppurative Otitis Media: Case Report and Literature Review

Vâţă,

Irimie-Băluţă,

Roşu

et al. 2023

Medicina

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“…The variations may be due to different groupings (which may include socioeconomic differences), the absence of active virus replication, or even methodological failure. HHV latency and the high serological prevalence found with this viral family do not reflect the active viral infection; therefore, the detection of latent particles can also influence the higher prevalence in some studies 2 , 3 , 21 , 43 , 44 .…”

Section: Discussionmentioning

confidence: 99%

Arbovirus, herpesvirus, and enterovirus associated with neurological syndromes in adult patients of a university hospital, 2017-2018

Leon

Lima

Boffi

et al. 2021

Rev. Soc. Bras. Med. Trop.

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“…There are some special predisposing factors of anaerobic meningitis. Clinicians should screen for predisposing factors, including otolaryngological infection (60%), gastrointestinal infection (10%), premature birth (10%), other causes (5%; congenital dermal sinus, head and neck tumor, ventricular shunt) and unknown causes (15%) (10). The dermal sinus is an abnormal channel between the skin surface and the central nervous system in the dorsal midline and is mostly discovered in the lumbosacral region.…”

Section: Introductionmentioning

confidence: 99%

Polymicrobial anaerobic bacterial meningitis secondary to dermal sinus: a case report

Luo¹,

Wang²,

Shen³

et al. 2021

Transl Pediatr

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Anaerobic bacterial meningitis is a rare infectious disease, and there are some special predisposing factors for it. We report a case of polymicrobial anaerobic bacterial meningitis in a nine-monthold boy who visited our hospital due to "fever with drowsiness and vomiting for 2 days". It was confirmed by the method of sanger sequencing after polymerase chain reaction (PCR) that the purulent meningitis was caused by a mixture of four anaerobic bacteria (Finegoldia magna, Campylobacter ureolyticus, Bacteroides fragilis and Porphyromonas bennonis). Even though there was no obvious structural abnormality on the skin surface, magnetic resonance imaging (MRI) examination suggested the presence of a sacrococcygeal dermal sinus. It was proven that anaerobic bacterial meningitis was secondary to retrograde infection of the dermal sinus. Finally, he was cured by a combination of anti-infection measures and surgical treatment.In conclusion, using appropriate molecular diagnostic techniques may quickly and accurately determine the pathogenic bacteria of anaerobic bacterial meningitis. When anaerobic bacterial meningitis occurs, the presence of structural abnormalities such as dermal sinus needs to be ruled out to avoid recurrence of the disease. In addition to anti-infective treatment, patients with dermal sinuses should undergo surgery as soon as possible to address abnormal structures and their root causes.

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Expanding Molecular Diagnostics for Central Nervous System Infections

Cited by 7 publications

References 50 publications

Polymicrobial Bacterial Meningitis in a Patient with Chronic Suppurative Otitis Media: Case Report and Literature Review

Polymicrobial Bacterial Meningitis in a Patient with Chronic Suppurative Otitis Media: Case Report and Literature Review

Arbovirus, herpesvirus, and enterovirus associated with neurological syndromes in adult patients of a university hospital, 2017-2018

Polymicrobial anaerobic bacterial meningitis secondary to dermal sinus: a case report

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