Expanding nanoparticle multifunctionality: size-selected cargo release and multiple logic operations

Chen, Wei; Cheng, Chi‐An; Xiang, Danlei; Zink, Jeffrey I.

doi:10.1039/d1nr00642h

Cited by 5 publications

(6 citation statements)

References 69 publications

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“…The incorporation of responsive modules to MTF-modified electrodes can indeed be a breakthrough, as it will impart the possibility of creating systems adaptable to external solicitations. A wealth of mesoporous responsive systems that stem from the combination of mesopores, nanoparticles, and stimuli-responsive molecules or polymers is available for exploring this concept, which leads to a wealth of different behaviors, from active gating to autonomous and programmable materials that might, one day, take their own decisions. ,− …”

Section: Discussionmentioning

confidence: 99%

“…A wealth of mesoporous responsive systems that stem from the combination of mesopores, nanoparticles, and stimuli-responsive molecules or polymers is available for exploring this concept, which leads to a wealth of different behaviors, from active gating to autonomous and programmable materials that might, one day, take their own decisions. 7 , 185 − 187 …”

Section: Discussionmentioning

confidence: 99%

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Ordered Mesoporous Electrodes for Sensing Applications

et al. 2023

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Electrochemical sensors have become increasingly relevant in fields such as medicine, environmental monitoring, and industrial process control. Selectivity, specificity, sensitivity, signal reproducibility, and robustness are among the most important challenges for their development, especially when the target compound is present in low concentrations or in complex analytical matrices. In this context, electrode modification with Mesoporous Thin Films (MTFs) has aroused great interest in the past years. MTFs present high surface area, uniform pore distribution, and tunable pore size. Furthermore, they offer a wide variety of electrochemical signal modulation possibilities through molecular sieving, electrostatic or steric exclusion, and preconcentration effects which are due to mesopore confinement and surface functionalization. In order to fully exploit these advantages, it is central to develop reproducible routes for sensitive, selective, and robust MTF-modified electrodes. In addition, it is necessary to understand the complex mass and charge transport processes that take place through the film (particularly in the mesopores, pore surfaces, and interfaces) and on the electrode in order to design future intelligent and adaptive sensors. We present here an overview of MTFs applied to electrochemical sensing, in which we address their fabrication methods and the transport processes that are critical to the electrode response. We also summarize the current applications in biosensing and electroanalysis, as well as the challenges and opportunities brought by integrating MTF synthesis with electrode microfabrication, which is critical when moving from laboratory work to in situ sensing in the field of interest.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ordered Mesoporous Electrodes for Sensing Applications

et al. 2023

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“…Starting from these simulations, the authors could setup the experimental bench considering an exposure of the solution sample to the low intensity B field of about 2 ± 0.3 mT. This kind of exposure, although using MNPs (embedded in the membrane of liposomes), is considered non-thermal with respect to other non-invasive magnetic stimuli available in the literature, where the goal is the use of superparamagnetic NPs to provide drug delivery nanosystems [22][23][24].…”

Section: Characterization Of the Exposure Setupmentioning

confidence: 99%

The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs

et al. 2021

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Stimuli-sensitive nanocarriers have recently been developed as a powerful tool in biomedical applications such as drug delivery, detection, and gene transfer techniques. Among the external triggers investigated, low intensity magnetic fields represent a non-invasive way to remotely control the release of compounds from a magneto-sensitive carrier. Magnetoliposomes (MLs), i.e., liposomes entrapping magnetic nanoparticles (MNPs), are studied due to their capacity to transport hydrophobic and hydrophilic agents, their easy production, and due to the ability of MNPs to respond to a magnetic actuation determining the triggered release of the encapsulated compounds. Here we investigated the design and optimization of the MLs to obtain an efficient on-demand release of the transported compounds, due to the magneto-mechanical actuation induced by applying low-intensity pulsed electromagnetic fields (PEMFs). In particular we studied the effect of the bilayer packing on the ability of MLs, with oleic acid-coated MNPs encapsulated in the bilayer, to respond to PEMFs application. Three kinds of MLs are produced with an increasing rigidity of the bilayer, defined as Liquid Disorder, Liquid Order, and Gel MLs and the delivery of a hydrophilic dye (as a model drug) is investigated. Results demonstrate the efficacy of the magnetic trigger on high-ordered bilayers, which are unable to dampen the perturbation produced by MNPs motion.

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“…6 In particular, chemical control of photoisomerization has allowed azobenzene derivatives to be exploited as logic gates and for drug delivery and small molecule release. [7][8][9] The photophysics of azobenzene have been well studied as a model system for transcis photoisomerization. Most reports describe the photophysical evolution of azobenzene that begins with excitation into the symmetry allowed S 2 excited state.…”

Section: Introductionmentioning

confidence: 99%

“…6 In particular, chemical control of photoisomerization has allowed azobenzene derivatives to be exploited as logic gates and for drug delivery and small molecule release. 7–9…”

Section: Introductionmentioning

confidence: 99%

Controlling excited-state dynamics via protonation of naphthalene-based azo dyes

Martin,

Hamburger,

Huang

et al. 2024

Phys. Chem. Chem. Phys.

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Expanding nanoparticle multifunctionality: size-selected cargo release and multiple logic operations

Abstract: Physically stimulated nanoparticles that deliver size-selected cargo and function as logic gates are reported. To achieve this goal the particle requires multiple components, and we recognized early on that the...

Cited by 5 publications

References 69 publications

Ordered Mesoporous Electrodes for Sensing Applications

Ordered Mesoporous Electrodes for Sensing Applications

The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs

Controlling excited-state dynamics via protonation of naphthalene-based azo dyes

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