Expanding Our Understanding of Children's Interstitial Lung Disease

Deterding, Robin R.

doi:10.1089/ped.2010.2302

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…NEHI is increasingly recognized worldwide as a chronic disease of infants and young children characterized by impressive clinical findings . This is the largest series of NEHI subjects from one center ever published.…”

Section: Discussionmentioning

confidence: 98%

Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy

Kerby

Wagner

Popler

et al. 2012

Pediatric Pulmonology

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Section: Discussionmentioning

confidence: 98%

Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy

Kerby

Wagner

Popler

et al. 2012

Pediatric Pulmonology

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Approach to the patient with Childhood Interstitial and Diffuse Lung Disease

Fiorino,

Fishman

2024

Pediatric Pulmonology

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Childhood Interstitial and Diffuse Lung Disease (chILD) encompasses a group of rare, chronic lung disorders in infants and children with overlapping clinical features but diverse etiologies. The clinical presentation of chILD is of chronic or recurring respiratory signs and symptoms, often including increased work of breathing and hypoxia, with diffuse radiographic abnormalities on chest imaging. Recognition can be challenging since some clinical features overlap with those of more common pediatric respiratory diseases including asthma and recurrent viral infections, among others. chILD should be considered as an underlying diagnosis when a patient's respiratory symptoms seem disproportionate to the clinical scenario and/or persist. The diagnostic process involves multiple steps and is tailored to the individual patient. Nearly all children will undergo imaging and pulmonary function testing, many will undergo bronchoscopy with bronchoalveolar lavage, many will receive genetic testing, and some will require lung biopsy. Treatment includes preventive care, evaluation for comorbidities, pharmacotherapy according to diagnosis, and ongoing disease surveillance, including revisiting genetic and histopathologic results as new clinical information becomes available and as our understanding of these rare disorders improves. The purpose of this review is to provide a broad approach to the diagnosis and management of patients with chILD.

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Interstitial lung disease in infants: new classification system, imaging technique, clinical presentation and imaging findings

Lee

2012

Pediatr Radiol

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Interstitial lung disease (ILD) is defined as a rare, heterogeneous group of parenchymal lung conditions that develop primarily because of underlying developmental or genetic disorders. Affected infants typically present with clinical syndromes characterized by dyspnea, tachypnea, crackles and hypoxemia. Until recently, the understanding of ILD in infants has been limited largely owing to a lack of evidence-based information of underlying pathogenesis, natural history, imaging findings and histopathological features. However, ILD in infants is now better understood and managed because of (1) advances in imaging methods that result in rapid and accurate detection, (2) improved thoracoscopic techniques for lung biopsy, (3) a consensus regarding the pathological criteria for these particular lung conditions and (4) a new classification system based on the underlying etiology of ILD. This article reviews the new classification system, imaging technique, clinical presentation and imaging findings of ILD in infants. Specialized knowledge of this new classification system in conjunction with recognition of characteristic imaging findings of ILD in infants has great potential for early and accurate diagnosis, which in turn can lead to optimal patient management.

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Expanding Our Understanding of Children's Interstitial Lung Disease

Cited by 5 publications

References 8 publications

Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy

Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy

Approach to the patient with Childhood Interstitial and Diffuse Lung Disease

Interstitial lung disease in infants: new classification system, imaging technique, clinical presentation and imaging findings

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