Expanding the 18F-Radiochemical Space: Synthesis and Applications of 1,1-18F-Difluorinated Alkenes

Abstract

The synthesis of 18F-perfluorinated motifs from [18F]fluoride is a non-trivial undertaking as highlighted by the few methods and range of motifs that are known. In this Synpacts article we highlight our recent work on the synthesis and derivatization of 1,1-18F-difluoroalkenes to expand the accessible radiochemical space with fluorine-18.1 Introduction2 Overview of the Main Strategies to Access 18F-Perfluorinated Motifs with [18F]Fluoride3 1,1-18F-Difluoroalkenes4 Conclusion