Expanding the application of tryptophan: Industrial biomanufacturing of tryptophan derivatives

Xiao, Shujian; Wang, Zhen; Wang, Bangxu; Hou, Bo; Cheng, Jie; Bai, Ting; Zhang, Yin; Wang, Wei; Yan, Lixiu; Zhang, Jiamin

doi:10.3389/fmicb.2023.1099098

Cited by 22 publications

(6 citation statements)

References 102 publications

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“…These fungal biochemical compounds include carbohydrates (β-glucans/lentinan, trehalose, chitosans) [ 210 ], carbohydrate-binding proteins (lectins) [ 211 ], mono- and polyunsaturated fatty acids(linoleic, oleic, palmitic) [ 212 ], phenolic compounds (caffeic, gallic, cinnamic, p-hydroxybenzoic, p-coumaric, and melatonin) [ 213 ], indole compounds (L-trytptophan) [ 214 ], vitamins (vitamins B complex, vitamin C, and tocopherols), terpenoids (carotenoids such as β-carotene and lycopene) [ 215 ], and unique molecules (e.g. ergothioneine and glutathione) [ 216 , 217 ].…”

Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

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Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a congenital blood disorder characterized by considerable phenotypic diversity. It comprises a group of disorders, with sickle cell anemia (SCA) being the most prevalent and serious genotype. Although there have been some systematic reviews of global data, worldwide statistics regarding SCD prevalence, morbidity, and mortality remain scarce. In developed countries with a lower number of sickle cell patients, cutting-edge technologies have led to the development of new treatments. However, in developing settings where sickle cell disease (SCD) is more prevalent, medical management, rather than a cure, still relies on the use of hydroxyurea, blood transfusions, and analgesics. This is a disease that affects red blood cells, consequently affecting most organs in diverse manners. We discuss its etiology and the advent of new technologies, but the aim of this study is to understand the various types of nutrition-related studies involving individuals suffering from SCD, particularly in Africa. The interplay of the environment, food, gut microbiota, along with their respective genomes collectively known as the gut microbiome, and host metabolism is responsible for mediating host metabolic phenotypes and modulating gut microbiota. In addition, it serves the purpose of providing essential nutrients. Moreover, it engages in direct interactions with host homeostasis and the immune system, as well as indirect interactions via metabolites. Nutrition interventions and nutritional care are mechanisms for addressing increased nutrient expenditures and are important aspects of supportive management for patients with SCD. Underprivileged areas in Sub-Saharan Africa should be accompanied by efforts to define and promote of the nutritional aspects of SCD. Their importance is key to maintaining well-being and quality of life, especially because new technologies and products remain limited, while the use of native medicinal plant resources is acknowledged.

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Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

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“…Subsequently, through several steps, this intermediate can be further converted into tryptophan [26]. Tryptophan can also serve as a precursor for many chemical substances and continue to be converted into downstream products such as indole and auxin through the tryptophan metabolism pathway [17]. In addition, OABA can also be catalyzed by anthranilic acid methyltransferase 1 (AAMT1) to produce the grape flavor compound methyl anthranilate [24,27].…”

Section: Synthesis Pathway 21 Oaba and Its Derivativesmentioning

confidence: 99%

“…Furthermore, fossil resources are non-renewable and excessive reliance on and exploitation of these resources will eventually lead to fuel exhaustion. Therefore, green, ecological, and sustainable synthesis is the trend for the future [15][16][17]. The metabolic pathways of ABA and its derivatives are present in various plants and microorganisms and are important components of the shikimate pathway [18].…”

Section: Introductionmentioning

confidence: 99%

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

Xiao,

Zeng,

Wang

et al. 2024

Sustainability

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Aminobenzoic acid and its derivatives are a class of aromatic compounds that are important foundational chemicals for various dyes, food additives, and pharmaceuticals. Their production relies on chemical synthesis using petroleum-derived substances such as benzene as precursors, but due to the toxicity, environmental pollution, and non-renewable nature of raw materials in chemical synthesis, some suitable alternative methods are gradually being developed. Green, environmentally friendly, and sustainable biosynthesis methods have gradually been favored by researchers, especially after the discovery of the synthetic pathways of aminobenzoic acid and its derivatives in plants and microorganisms. Based on the purpose of protecting the ecological environment, reducing the use of non-renewable resources, and providing theoretical support for industrial green development, this article reviews the biosynthesis pathways of ortho-aminobenzoic acid, meta-aminobenzoic acid, para-aminobenzoic acid, and its derivatives such as catechol, folic acid, etc., and lists some examples of biosynthesis, analyzes their advantages and disadvantages, summarizes and looks forward to the future development direction of biosynthesis of aminobenzoic acid and its derivatives.

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“…As one of the essential amino acids, tryptophan is key in the (bio)synthesis of peptides, proteins, and many small indole-containing molecules of biological relevance. − In synthetic chemistry routes, harnessing this abundant and biobased building block can be a large asset for their overall sustainability and cost efficiency . Moreover, tryptophan residues are often tied to specific protein functions and possess intrinsic fluorescence, which results in a widespread use of tryptophan analogues in biochemical research. − Along with the rise of bioconjugation methods for the site-selective synthetic modification of peptides or proteins, the catalytic conversion of the C–H bonds in native tryptophan residues is a promising approach to further expand such synthetic possibilities. − Rather than reacting on functional groups, such as −NH 2 or −SH, in lysine or cysteine or relying on the labeling with non-native amino acid residues (e.g., azide or alkyne functional groups), a recent research focus is to translate the advances in Pd-catalyzed C–H bond activation on the C2 position of indole scaffolds − toward the direct C–H coupling of tryptophan residues.…”

Section: Introductionmentioning

confidence: 99%

Overcoming Pd Catalyst Deactivation in the C–H Coupling of Tryptophan Residues in Water Using Air as the Oxidant

Beckers,

Vos,

Van Dessel

et al. 2024

ACS Catal.

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The Pd-catalyzed C−H activation of natural tryptophan residues has emerged as a promising approach for their direct synthetic modification. While using water as the solvent and harnessing air as the oxidant is enticing, these conditions induce catalyst deactivation by promoting the formation of inactive Pd(0) clusters. In this work, we have studied optimized Pd-based catalytic systems via nonsteady state kinetic analysis and in situ Xray absorption spectroscopy (XAS) to overcome catalyst deactivation, which enables the effective use of lower Pd loadings.

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Expanding the application of tryptophan: Industrial biomanufacturing of tryptophan derivatives

Cited by 22 publications

References 102 publications

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

A New Direction for the Green, Environmentally Friendly and Sustainable Bioproduction of Aminobenzoic Acid and Its Derivatives

Overcoming Pd Catalyst Deactivation in the C–H Coupling of Tryptophan Residues in Water Using Air as the Oxidant

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