Expanding the armamentarium for neutrophil‐mediated angiogenesis

Hsu, Brian; Siegel, Peter M.

doi:10.1002/hep.29143

Cited by 1 publication

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neutrophil-derived MMP-9 catalyzes the release of ECM-bound VEGF through proteolytic cleavage and finally induces tumor angiogenesis. 53 Tian et al demonstrated that CRC cells induced neutrophils to promote liver metastasis via the Anterior gradient-2 (AGR2)-CD98hc-xCT axis. 54 Therefore, neutrophils play a role in the process of metastasis in a dual way.…”

Section: Neutrophilicmentioning

confidence: 99%

“…In addition, neutrophils directly express VEGF. Neutrophil‐derived MMP‐9 catalyzes the release of ECM‐bound VEGF through proteolytic cleavage and finally induces tumor angiogenesis 53 . Tian et al demonstrated that CRC cells induced neutrophils to promote liver metastasis via the Anterior gradient‐2 (AGR2)‐CD98hc‐xCT axis 54 …”

Section: Nonparenchymal Cells Of the Livermentioning

confidence: 99%

See 1 more Smart Citation

Cells in the liver microenvironment regulate the process of liver metastasis

Wang,

Jie,

Yao

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

The research of liver metastasis is a developing field. The ability of tumor cells to invade the liver depends on the complicated interactions between metastatic cells and local subpopulations in the liver (including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells, and immune‐related cells). These interactions are mainly mediated by intercellular adhesion and the release of cytokines. Cell populations in the liver microenvironment can play a dual role in the progression of liver metastasis through different mechanisms. At the same time, we can see the participation of liver parenchymal cells and nonparenchymal cells in the process of liver metastasis of different tumors. Therefore, the purpose of this article is to summarize the relationship between cellular components of liver microenvironment and metastasis and emphasize the importance of different cells in the occurrence or potential regression of liver metastasis.

show abstract

Section: Neutrophilicmentioning

confidence: 99%

Section: Nonparenchymal Cells Of the Livermentioning

confidence: 99%