Expanding the comprehensive national neonatal screening programme in the United Arab Emirates from 1995 to 2011

H, Al Hosani; Salah, Mohamed; Hm, Osman; Hm, Farag; El-Assiouty, L; Saade, D.; Hertecant, Jozef

doi:10.26719/2014.20.1.17

Cited by 43 publications

(43 citation statements)

References 20 publications

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“…Data from another large screening program in Lebanon report a prevalence of 1: 1,700 [27]. These rates are comparable to those reported from the United Arab Emirates (1: 1,873) [28], and from the Greek Cypriot population (1: 1,800) [29] but higher than some of the reported rates from Turkey (1: 2,326) [22], Egypt (1: 3,587) [23], and from different regions in Saudi Arabia (1: 2,759 [24] and 1: 4,208 [25]). Nevertheless, this apparently higher rate in the overall incidence of congenital hypothyroidism in Lebanon does not explain the magnitude of the increase in the rates detected in our population of VLBW infants.…”

Section: Discussionsupporting

confidence: 73%

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center

Tfayli¹,

Charafeddine²,

Tamim³

et al. 2018

Horm Res Paediatr

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Background/Aims: Preterm newborns with a very low birth weight (VLBW) of < 1,500 g have an atypical form of hypothyroidism with a delayed rise in TSH, necessitating a second newborn screening specimen collection. The aims of this study were to survey the compliance with second newborn screening to detect delayed TSH rise in VLBW preterm infants at a tertiary care center, and to determine the rate of atypical hypothyroidism. Methods: Retrospective review of the records of 104 preterm VLBW infants. Late TSH rise was defined as an increase in TSH concentration after 14 days of age in the presence of a normal initial screen. Results: The compliance rate was 92% for the second screening. High rates of hypothyroidism (16.3%) and of late TSH rise (4.8%) were detected. Patients with hypothyroidism had a significantly lower birth weight (p = 0.01) and longer hospital stay (p = 0.004). Patients with late versus those with early TSH rise had a significantly lower mean birth weight (851 ± 302 vs. 1,191 ± 121 g, p = 0.004). Conclusion: The rates of early and late TSH rise in this VLBW population were higher than those in the literature and could be due to the use of povidone-iodine disinfectants. The yield of a second TSH screening in this study was high indicating the need for vigilance in screening VLBW preterm infants.

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Section: Discussionsupporting

confidence: 73%

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center

Tfayli¹,

Charafeddine²,

Tamim³

et al. 2018

Horm Res Paediatr

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“…The same disorders of hormone synthesis seem to explain the moderately severe nature of the delayed milestones observed in our study, although the other clinical signs were typical for hypothyroidism (1-3, 5, 22 This trend of a higher incidence of dyshormonogenesis is found in Middle East countries (19)(20)(21). Although, we identified no consanguinity among families, the fact that patients belonged to very closed families, particularly from the same village, might suggest the presence of similar genetic characteristics and explain the predominance of dyshormonosynthesis in our study population (1)(2)(3)20).…”

Section: Discussioncontrasting

confidence: 40%

Dyshormonogenesis seems to be more frequent in a group of Cameroonian children with congenital hypothyroidism

Sap¹,

Koki²,

Dongmo³

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Congenital hypothyroidism is a main congenital endocrine disorder, affecting 1 in 4000 births. It is not well described in sub-Saharan countries, and to draw attention to that issue, we decided to describe affected pediatric patients. We retrospectively analyzed the records of eight patients over a period of 6 years. We analyzed clinical sings of hypothyroidism and psychomotor development; hormonal assays and thyroid ultrasound were performed. We included four boys and four girls aged from 3 to 84 months at diagnosis with a median thyroid-stimulating hormone (TSH) level of 156.5 mUI/L. All except one present with a moderate psychomotor delay. Other clinical signs were classical for hypothyroidism. Thyroid ultrasound performed showed a goiter in half of patients, a normal gland in three of them and a hypoplasic gland in the last one, consonant with dyshormonogenesis. We therefore concluded that dyshormonogenesis seems to be more frequent in our context, and this raised the issue of neonatal screening of hypothyroidism in Africa.

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“…114,115 Likewise, successful screening models in Lebanon and Qatar have demonstrated the feasibility of using screening laboratories in other countries to provide NBS services. 116,117 National NBS programs with extensive screening coverage are now present in Bahrain, Egypt, Iran, Israel, Kuwait, Oman, Qatar (only for Qataris), State of Palestine, Saudi Arabia, and the United Arab Emirates.…”

Section: Middle East and North Africamentioning

confidence: 97%

Current status of newborn screening worldwide: 2015

Therrell

Padilla

Loeber³

et al. 2015

Seminars in Perinatology

484

418

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Expanding the comprehensive national neonatal screening programme in the United Arab Emirates from 1995 to 2011

Cited by 43 publications

References 20 publications

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center

Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center

Dyshormonogenesis seems to be more frequent in a group of Cameroonian children with congenital hypothyroidism

Current status of newborn screening worldwide: 2015

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