Expanding the functional role of long noncoding RNAs

Johnsson, Per; Morris, Kevin V.

doi:10.1038/cr.2014.104

Cited by 40 publications

(32 citation statements)

References 7 publications

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“…37 In addition, as lncRNAs are likely to function through the formation of secondary and tertiary structures, the major evolutionary constraint for lncRNAs could be to maintain their functional structures. 38-40 However, accurate prediction of lncRNA structures still remains a big challenge for the field.…”

Section: General Characteristics Of Lncrnasmentioning

confidence: 99%

Long non-coding RNAs as regulators of the endocrine system

Knoll¹,

Lodish²,

Sun³

2015

Nat Rev Endocrinol

205

147

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Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments and establish active or repressive chromatin states; others are cytosolic and regulate the stability of mRNA or act as microRNA sponges. This Review summarizes the current knowledge of lncRNAs as regulators of the endocrine system, with a focus on the identification and mode of action of several endocrine-important lncRNAs. We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.

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Section: General Characteristics Of Lncrnasmentioning

confidence: 99%

Long non-coding RNAs as regulators of the endocrine system

Knoll¹,

Lodish²,

Sun³

2015

Nat Rev Endocrinol

205

147

View full text Add to dashboard Cite

show abstract

“…lncRNAs are transcripts of >200 nucleotides and conventionally cannot be translated into proteins to participate in a large number of biological processes (8,9). However, recent studies hypothesized that a number of lncRNAs are key developmental regulators that are involved in cell homeostasis and proliferation (9,10). Notably, increasing numbers of studies are indicating that the abnormal expression of certain lncRNAs is associated with tumor growth, carcinogenesis or metastasis in a range of malignancies (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The findings may improve our understanding of the roles and the clinic implications of HOTAIR in the development and progression of AML. 9 ) of the patients at the time of diagnosis, and from 33 patients who were in CR following two cycles of chemotherapy. Additionally, 40 PB specimens were obtained from healthy donors as negative controls.…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Zheng

Chen

et al. 2015

Oncology Letters

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Abstract. The long non-coding RNA, HOX transcript antisense intergenic RNA (HOTAIR), has been indicated to have involvement in a number of cancers, however, its role in acute myeloid leukemia (AML) is unknown. The present study aimed to investigate the pattern of HOTAIR expression in AML and to evaluate its clinical significance in tumor progression. Quantitative polymerase chain reaction was performed to examine the HOTAIR expression in mononuclear cells from the bone marrow (BM) or peripheral blood specimens of 85 patients with newly diagnosed AML. The association of HOTAIR expression with the clinicopathological factors and prognosis of AML patients was statistically analyzed. The expression of HOTAIR was significantly upregulated in the AML patients compared with the healthy controls (mean expression value, 3.87±0.29 vs. 1.28±0.09; P<0.001), and markedly decreased in the patients post-treatment compared with pre-treatment (4.76±0.47 vs. 2.81±0.27; P<0.001). Moreover, high levels of HOTAIR were associated with higher white blood cell and BM blast counts (P<0.001 and P=0.001, respectively), and lower hemoglobin and platelet counts (P=0.007 and 0.001, respectively). Patients with a high level of HOTAIR expression had relatively poor overall survival (OS; 20.5 vs. 32.1 months, P=0.001) and relapse-free survival (21.5 vs. 33.6 months, P=0.001) times compared with those with a low level of HOTAIR expression. These data demonstrated that HOTAIR expression was upregulated in newly diagnosed AML patients and was associated with leukemic burden, and DFS and OS times. HOTAIR may represent a biomarker of a poor prognosis and is a potential therapeutic target for AML treatment.

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“…Given the large number of lncRNAs whose functions are still to be elucidated, there is clear potential for widespread regulation of chromatin modifications and gene expression. Thus, lncRNA are dynamic in their mechanisms of action, operating through cis or trans mechanisms to influence transcription, splicing and/or translation 3, 21, 22 . LncRNAs are emerging as important regulators of a variety of cellular responses, developmental and disease processes 23–31 .…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Disease

et al. 2015

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Long noncoding RNAs (lncRNAs) are an emerging class of genomic regulatory molecules reported in various species. In the rat, which is one of the major mammalian model organisms, discovery of lncRNAs on a genome-wide scale is lagging. Renal LncRNA sequencing and lncRNA transcriptome analysis was conducted in three rat strains that are widely used in cardiovascular and renal research, the Dahl salt-sensitive (S) rat, the Spontaneously Hypertensive Rat (SHR) and the Dahl salt-resistant (R) rat. Through the RNA sequencing approach, 3,273 transcripts were identified as rat lncRNAs. A majority of lncRNAs were without predicted target genes. Differential expression of 273 and 749 lncRNAs was detected between S versus R and S versus SHR comparisons respectively. To couple the observed differential expression of lncRNAs with the status of mRNAs, an mRNA transcriptome analysis was conducted. Several cis mRNA genes were co-regulated with lncRNAs. Of these, the protein expression status of four target genes, Asb3, Chac2, Pex11b and Sp5, were differentially expressed between the relevant strain comparisons thereby suggesting that the differentially expressed lncRNAs associated with these genes are candidate genetic determinants of blood pressure. This study serves as a first-generation catalog of rat lncRNAs and illustrates the prioritization of lncRNAs as positional candidates for complex polygenic traits.

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Expanding the functional role of long noncoding RNAs

Cited by 40 publications

References 7 publications

Long non-coding RNAs as regulators of the endocrine system

Long non-coding RNAs as regulators of the endocrine system

Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia

Genome-Wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Disease

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