2022
DOI: 10.21203/rs.3.rs-2050301/v1
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Expanding the Legionella pan-kinome

Abstract: The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins into the host cell with the aim of disturbing and hijacking cellular processes for their benefit. Despite intensive studies, many effectors remain uncharacterized. Motivated by the richness of Legionella effector repertoires and their oftentimes atypical biochemistry, also by several known atypical Legionella effector kinases and pseudokinases, we undertook an in silico survey and exploration of the pan-kinome of the Leg… Show more

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