Expanding the scope and scale of microbiome research

Knight, Rob; Ley, Ruth E.; Raes, Jeroen; Grice, Elizabeth A.

doi:10.1186/s13059-019-1804-2

Cited by 1 publication

(2 citation statements)

References 17 publications

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“…Newly emerging methods such as long-read DNA sequencing, hybrid assembly, or proximity ligation prior to sequencing can help reduce such uncertainties. 90 , 92 …”

Section: A New Millennium Evolving Methods and Understanding: What Ha...mentioning

confidence: 99%

“…A major challenge to assembly has also been that the dominant sequencing technology currently applied for environmental metagenomics, Illumina (Illumina, Inc., San Diego, CA), produces large sequence libraries, but with very short (∼150 bp) reads, which are computationally challenging to accurately piece together. Newly emerging methods such as long-read DNA sequencing, hybrid assembly, or proximity ligation prior to sequencing can help reduce such uncertainties. , …”

Section: A New Millennium Evolving Methods and Understanding: What Ha...mentioning

confidence: 99%

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Antimicrobial Resistance Monitoring of Water Environments: A Framework for Standardized Methods and Quality Control

Liguori

Keenum

Davis

et al. 2022

Environ. Sci. Technol.

143

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Antimicrobial resistance (AMR) is a grand societal challenge with important dimensions in the water environment that contribute to its evolution and spread. Environmental monitoring could provide vital information for mitigating the spread of AMR; this includes assessing antibiotic resistance genes (ARGs) circulating among human populations, identifying key hotspots for evolution and dissemination of resistance, informing epidemiological and human health risk assessment models, and quantifying removal efficiencies by domestic wastewater infrastructure. However, standardized methods for monitoring AMR in the water environment will be vital to producing the comparable data sets needed to address such questions. Here we sought to establish scientific consensus on a framework for such standardization, evaluating the state of the science and practice of AMR monitoring of wastewater, recycled water, and surface water, through a literature review, survey, and workshop leveraging the expertise of academic, governmental, consulting, and water utility professionals.

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“…Newly emerging methods such as long-read DNA sequencing, hybrid assembly, or proximity ligation prior to sequencing can help reduce such uncertainties. 90 , 92 …”

Section: A New Millennium Evolving Methods and Understanding: What Ha...mentioning

confidence: 99%

Section: A New Millennium Evolving Methods and Understanding: What Ha...mentioning

confidence: 99%

Antimicrobial Resistance Monitoring of Water Environments: A Framework for Standardized Methods and Quality Control

Liguori

Keenum

Davis

et al. 2022

Environ. Sci. Technol.

143

View full text Add to dashboard Cite

show abstract

Expanding the scope and scale of microbiome research

Cited by 1 publication

References 17 publications

Antimicrobial Resistance Monitoring of Water Environments: A Framework for Standardized Methods and Quality Control

Antimicrobial Resistance Monitoring of Water Environments: A Framework for Standardized Methods and Quality Control

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