2016
DOI: 10.3324/haematol.2015.138180
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Expanding transplant options to patients over 50 years. Improved outcome after reduced intensity conditioning mismatched-unrelated donor transplantation for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the EBMT

Abstract: T he outcome of patients undergoing HLA-matched unrelated donor allogeneic hematopoietic cell transplantation following reduced-intensity conditioning or myeloablative regimens is reported to be equivalent; however, it is not known if the intensity of the conditioning impacts outcomes after mismatched unrelated donor transplantation for acute myeloid leukemia. Eight hundred and eighty three patients receiving reduced-intensity conditioning were compared with 1041 myeloablative conditioning regimen recipients i… Show more

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Cited by 36 publications
(26 citation statements)
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“…Both OS and TRM for AYAs undergoing allogeneic HSCT were poor in our study, consistent with past reports demonstrating inferior outcomes for this population, primarily due to higher rates of TRM . These dismal outcomes may reflect the nearly one‐third of patients identified as having high‐risk disease by the DRI, and represent a similar proportion as compared to other studies conducted at large, adult transplant centers . Better patient selection criteria including the use of more sensitive minimal residual disease testing and risk scores such as the HCT‐CI and DRI have begun to improve outcomes for these patients in recent years …”
Section: Discussionsupporting
confidence: 63%
“…Both OS and TRM for AYAs undergoing allogeneic HSCT were poor in our study, consistent with past reports demonstrating inferior outcomes for this population, primarily due to higher rates of TRM . These dismal outcomes may reflect the nearly one‐third of patients identified as having high‐risk disease by the DRI, and represent a similar proportion as compared to other studies conducted at large, adult transplant centers . Better patient selection criteria including the use of more sensitive minimal residual disease testing and risk scores such as the HCT‐CI and DRI have begun to improve outcomes for these patients in recent years …”
Section: Discussionsupporting
confidence: 63%
“…[1][2][3][4]8,9,[25][26][27][28][29] In recent years, new conditioning regimens have been explored to improve transplantation outcomes in AML. [1][2][3][4]8,9,[25][26][27][28][29] In recent years, new conditioning regimens have been explored to improve transplantation outcomes in AML.…”
Section: Discussionmentioning
confidence: 99%
“…The impact of dose intensity on outcomes in AML patients has been the focus of many studies since the development of non-myeloablative/RIC regimens in the last 2 decades [1318]. These studies have focussed mainly on patients given PBSC as stem cell source.…”
Section: Discussionmentioning
confidence: 99%