This paper aims to identify and examine the relationships between individual life domains of mobile information services (MIS) and the overall domain, and their impact on the quality of life (QoL) of Japanese Internet users. Questionnaires were distributed online to Japanese Internet users aged 15 to 69, sampled from Japan's Internet population. We obtained 2,997 effective responses, or 72.1% of the entire sample. Comprehensive analyses of the relationships between constructs were conducted using PLS-SEM as this analytical method is appropriate for a model with a reflective construct and formative constructs. The results based on the bottom-up spillover theory clearly indicated that the relationship between individual and overall contribution in the specified model is valid and reliable for analysis. The contribution of the health life domain has the highest influence on the overall contribution to the QoL for Japanese Internet users as demonstrated by this study for the first time. Further, positive significant individual domains were noted in a descending order, as follows: cultural life domain, trustworthy life domain, leisure life domain, consumer life domain, and safety life domain.