Expansion of Pulmonary CD8+CD56+ Natural Killer T-Cells in Hypersensitivity Pneumonitis

Korošec, Peter; Osolnik, Katarina; Kern, Izidor; Šilar, Mira; Mohorcic, Katja; Košnik, Mitja

doi:10.1378/chest.07-0128

Cited by 34 publications

(35 citation statements)

References 31 publications

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“…An exuberant production of IgG antibody against the offending antigen is usually identifi ed, but is not causative. 39 Cell-mediated reactions, including the cells like T lymphocytes and natural killer T cells, 40 are believed to play an important role. 34 , 36 , 41 Various cytokines are elevated in hypersensitivity pneumonitides, including IL-8, IL-12, TNF-α, and interferon γ.…”

Section: T Able 2 T Ypes Of a Lveolar H Emorrhage S Yndromesmentioning

confidence: 99%

Interstitial Lung Disease in Children Older Than 2 Years

Vece

Fan

2010

Pediatric Allergy, Immunology, and Pulmonology

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The spectrum of childhood interstitial lung diseases (chILD) encompasses a group of heterogeneous, rare disorders in children characterized by diffuse pulmonary infi ltrates and disordered gas exchange. Whereas the disorders that present in early life are unique to children, those that present in older children are also seen in adults. This review will concentrate on chILD presenting in children older than 2 years of age with a focus on the idiopathic interstitial pneumonias, connective tissue diseases, alveolar hemorrhage, and hypersensitivity pneumonitis. A systematic approach to diagnosis that includes a careful history and physical, computed tomography of the chest, bronchoalveolar lavage, and lung biopsy can be very helpful in establishing the correct diagnosis. Treatment approaches are described, including general supportive measures, indications for a trial of systemic corticosteroids, or other immunomodulating therapies, and when lung transplantation reserved for those with end-stage lung disease should be considered.

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Section: T Able 2 T Ypes Of a Lveolar H Emorrhage S Yndromesmentioning

confidence: 99%

Interstitial Lung Disease in Children Older Than 2 Years

Vece

Fan

2010

Pediatric Allergy, Immunology, and Pulmonology

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“…In the acute and subacute hypersensitivity pneumonitis, Pathology of hypersensitivity pneumonitis Takemura et al 441 CD8þ T cells are predominant, whereas in the chronic form with fibrosis, CD4/8 increased [11,12,[40][41][42][43][44][45]. Phenotype of infiltrating lymphocytes is different in the stage of disease and depends on the antigen species, for example, low CD4/CD8 in summer-type hypersensitivity pneumonitis, more in farmer's lung and bird-fancier's lung [11,12,[41][42][43]46].…”

Section: Bronchoalveolar Lavagementioning

confidence: 99%

Pathology of hypersensitivity pneumonitis

Takemura

Akashi

Ohtani

et al. 2008

Current Opinion in Pulmonary Medicine

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“…Although such finding has not been reported in the literature, we had observed it in another series of patients comparing EP and COP/BOOP [33]. In a recent study by Korosec et al [34], the absolute CD3+CD16/56+ cell count was higher in HSP compared to patients with other ILDs, suggesting a possible contribution of the above cells in the pathogenesis of HSP.…”

Section: Discussionmentioning

confidence: 45%

Bronchoalveolar Lavage Fluid Eosinophils Are Correlated to Natural Killer Cells in Eosinophilic Pneumonias

Papakosta

Manika²,

Kyriazis³

et al. 2009

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Background: Eosinophilic lung diseases comprise a group of heterogeneous pulmonary disorders linked by increased eosinophils in bronchoalveolar lavage fluid (BALF). There is supporting evidence that natural killer (NK) cells participate in the regulation of eosinophilic inflammation. Objective: Our aim was to investigate the relationship between eosinophils and NK cells in BALF in patients with different interstitial lung diseases (ILDs) focusing on eosinophilic pneumonias. Methods: Of 114 patients who presented with increased BALF eosinophils (>5%), 74 patients were classified into the following groups: 27 had eosinophilic pneumonia (EP), 17 had idiopathic pulmonary fibrosis (IPF), 16 had hypersensitivity pneumonitis (HSP) and 14 had cryptogenic organizing pneumonia (COP/BOOP). Total BALF cells, cell density and cell differential counts were assessed and lymphocyte subsets CD3+, CD4+, CD8+, CD19+, CD3–CD16/56+ (NK) and CD3+CD16/56+ (NKT) were determined by flow cytometry. Results: Significant differences were observed in the percentages of lymphocytes (p < 0.001) and CD3+CD16/56+ cells (p = 0.023) among patient groups. In patients with EP, the percentage of eosinophils correlated positively with the number of CD3–CD16/56+ cells (r = 0.522, p = 0.005), the percentage of CD3–CD16/56+ cells (r = 0.690, p < 0.001), and the absolute count of CD3+CD16/56+ absolute cells (r = 0.609, p = 0.001). However, in patients with IPF, HSP or COP/BOOP, no correlation between the percentage of eosinophils and CD3–CD16/56+ or CD3+CD16/56+ cells was observed. Conclusions: Eosinophil inflammation seems to develop through a different pathway in EP compared to other ILDs.

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Expansion of Pulmonary CD8+CD56+ Natural Killer T-Cells in Hypersensitivity Pneumonitis

Cited by 34 publications

References 31 publications

Interstitial Lung Disease in Children Older Than 2 Years

Interstitial Lung Disease in Children Older Than 2 Years

Pathology of hypersensitivity pneumonitis

Bronchoalveolar Lavage Fluid Eosinophils Are Correlated to Natural Killer Cells in Eosinophilic Pneumonias

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