Expectation bias with respect to growth hormone therapy in Turner syndrome

Jh, Brämswig

doi:10.1530/eje.0.1370446

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…The comparably less demanding design of the current study allowed for a study that was relatively free of industry support and completely free of its influence. This has been suggested to induce a bias in favor of publication of uncontrolled positive results, often in non-peer-reviewed articles (16,17).…”

Section: Discussionmentioning

confidence: 99%

Final height in young women with Turner syndrome after GH therapy: an open controlled study

Hochberg

Zadik²

1999

European Journal of Endocrinology

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GH therapy has been applied to patients with Turner syndrome for over a decade, but small sample size, delayed initiation of therapy into adolescent age and comparison with historical control subjects limit the usefulness of these studies for appraisal of the effect of GH on final adult height. We report 49 young women with Turner syndrome who completed a clinical trial in an open, non-randomized, agematched controlled study of GH, given as daily s.c. injections at a weekly dose of 8.2 mg/m 2 for 1.9-7.5 years. Final height was defined as the measurement taken 2 years or more after height velocity declined below 2 cm/year and after a bone age of 15 'years'. The gain in height was evaluated in three ways. The mean final height gain, compared with the control group, was 4.4 cm. When corrected for the projected height at inception of therapy, the mean gained height was 5.3 cm above the control group. Shorter girls showed better response to GH then did taller girls. After correcting for parental height, the mean gain was 4.7 cm. The adult height of the GH-treated Turner women was significantly correlated with the target height, whereas no such correlation was obtained for control untreated women. Furthermore, no correlation was observed between height gain and the age or duration of GH therapy, or the age of inception of estrogen replacement therapy. It is concluded that GH therapy augments final height of girls with Turner syndrome by a mean 4.4-5.3 cm, depending on the method of evaluation, and that shorter girls may be preferred candidates for such therapy. GH therapy can be initiated after age 10 years and there is no reason to delay estrogen therapy beyond the age of 12. Indirect evidence suggests that high-dose GH therapy may surmount a pathophysiological resistance in the GH-IGF-I axis.

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Section: Discussionmentioning

confidence: 99%

Final height in young women with Turner syndrome after GH therapy: an open controlled study

Hochberg

Zadik²

1999

European Journal of Endocrinology

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“…Although one study suggested that all treated girls reached or exceeded their predicted adult height, 22 other studies have not. 33,[38][39][40][41] The ideal dosing regimens and duration of treatment have not been established. 36,42 It has been estimated that the cost of recombinant human growth hormone per centimeter of final gain in height is approximately $29,000.…”

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confidence: 99%

Turner's Syndrome

2004

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Turner Syndrome

Sybert

2005

Management of Genetic Syndromes

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Turner syndrome affects 1/3000 females. The natural history of this sex chromosome aneuploidy is marked by problems in lymphatic development, skeletal development and growth, gonadal function, cardiac and renal malformations, and a number of specific cognitive findings. An increased risk for hypothyroidism, sensorineural hearing loss, hypertension, and other problems is recognized. Evaluation and management are reviewed.

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Expectation bias with respect to growth hormone therapy in Turner syndrome

Cited by 6 publications

References 10 publications

Final height in young women with Turner syndrome after GH therapy: an open controlled study

Final height in young women with Turner syndrome after GH therapy: an open controlled study

Turner's Syndrome

Turner Syndrome

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