Expected sensitivity to antibiotics in bacterial infections

Streinu-Cercel, Oana

doi:10.11599/germs.2013.1030

Cited by 9 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Medical history of the patients, results of physical examination, and multiple laboratory parameters were analysed to calculate Carmeli's score in order to identify patients susceptible to be colonized with multidrug-resistant bacteria at the beginning of the hospitalization. The scoring and stratification were based upon the presence of Carmeli's risk factors [36, 37]. Risk factors were ranked with 1, 2, or 3 points according to the prediction for infection with susceptible, resistant, or multidrug-resistant microorganisms.…”

Section: Methodsmentioning

confidence: 99%

Recent Advances in Investigation, Prevention, and Management of Healthcare-Associated Infections (HAIs): Resistant Multidrug Strain Colonization and Its Risk Factors in an Intensive Care Unit of a University Hospital

Zaha

Kiss

Hegedűs

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Active screening for resistant multidrug strain carriers remains an important component of infection control policy in any healthcare setting indifferent of financial and logistical costs. The objective of our study was to determine the spectrum of bacterial colonization individually among intensive care unit patients. A retrospective observational study was performed in the Intensive Care Unit of Emergency Clinical County Hospital of Oradea during 2017. Medical records of the patients were used for evaluation of source of ICU admission, previous antibiotic therapy, comorbidities, and length of hospital stay. Nasal and groin swabs for MRSA detection and rectal swabs for ESBL, VRE, and CRE detection were collected upon ICU admission of all patients in the first 24 hours and after 7 days. Swab samples were processed for isolation and identification of these resistant multidrug strains. Bacterial colonization on admission was detected in a quarter of patients included in the study. Carbapenemase-producing bacteria were the most common colonizers (21.16%). On admission, 12.06% of patients have been colonized by ESBL-producing members of the family Enterobacterales. Risk factors for colonization on admission to the ICU were chronic liver diseases and chronic renal failure for ESBL infection and chronic liver disease for CRE in male patients. Evaluation of Carmeli’s score for male patients showed association only with CRE colonization. Chronic renal failure was found as risk factor for ESBL colonization in female patients. The prevalence of MRSA was 5.23% and less than 1% for VRE. There was no association between any risk factors studied and the presence of S. aureus or VRE upon admission. The 7-day ICU stay also proved to be an increased risk for ESBL and CRE infection.

show abstract

Section: Methodsmentioning

confidence: 99%

Recent Advances in Investigation, Prevention, and Management of Healthcare-Associated Infections (HAIs): Resistant Multidrug Strain Colonization and Its Risk Factors in an Intensive Care Unit of a University Hospital

Zaha

Kiss

Hegedűs

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Another limitation of our study is that clinicians at our institutions do not routinely employ scoring systems such as the CARMELI score or the DRIP score. [ 20 , 28 ] Lastly, our classification of patients coming in from the community as having COBP may be imprecise as it fails to differentiate individuals with healthcare exposure (e.g., recent hospitalization, residence in a nursing home, use of chronic dialysis) from those without such exposure. The most recent IDSA/ATS guidelines recommends against using the classification of healthcare-associated pneumonia as it may lead to greater unnecessary use of broad-spectrum antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Ceftriaxone resistance and adequacy of initial antibiotic therapy in community onset bacterial pneumonia

et al. 2022

View full text Add to dashboard Cite

Much remains unknown about the impact of initial antibiotic adequacy on mortality in community onset bacterial pneumonia (COBP). Therefore, we performed a study to determine how the adequacy of initial antibiotic therapy affects in-hospital mortality for patients with COBP. We carried out a retrospective cohort study among the 11 BJC Healthcare community and academic hospitals in Missouri and Illinois. The electronic medical records for BJC Healthcare were queried to obtain a set of patient admissions with culture positive (respiratory or blood) COBP admitted from January 1, 2016 through December 31, 2019. Patients with COBP required an International Classification of Diseases (ICD)-10 diagnostic code for pneumonia, admission to the hospital through an emergency department, a chest radiograph with an infiltrate, an abnormal white blood cell count or temperature, an order for 1 or more new antibiotics, and a positive respiratory or blood culture. Antibiotic selection was deemed adequate if the patient had organisms susceptible to at least one of the antibiotics received according to in vitro testing using standard laboratory breakpoints. Among 36,645 screened pneumonia admissions, 1843 met criteria for culture positive COBP. Eight hundred nineteen (44.4%) had ceftriaxone-resistant (CTX-R) organisms and 1024 had ceftriaxone-sensitive (CTX-S) organisms. The most common CTX-R pathogens were methicillin resistant Staphylococcus aureus (46.9%), Pseudomonas species (38.4%), and Escherichia coli (4.5%). On the day of admission 71% of all patients were given adequate antibiotic treatment (62.2% of CTX-R and 77.9% of CTX-S). Unnecessarily broad initial treatment was administered to 57.1% of CTX-S patients. In a logistic regression model accounting for comorbidities and severity of illness, inadequate therapy on the day of admission was associated with higher in-hospital mortality ( P = .005). Among CTX-S patients who were adequately treated, initial use of unnecessarily broad antibiotics was associated with increased in-hospital mortality ( P = .003). Ceftriaxone resistance was common in this cohort of culture positive COBP patients. Inappropriate coverage on day of admission was associated with greater likelihood of in-hospital mortality.

show abstract

“…We aim to perform a prospective study on bi-compartmental evaluation of bacterial prints in patients with infectious diseases, within the full range of Carmeli scores [ 2 ]. Serial samples will be collected from normally-sterile bodily compartments, at three different time-points: baseline (initiation of antimicrobial therapy), end-of-treatment, 3-week follow-up.…”

Section: Study Hypothesismentioning

confidence: 99%

Bi-compartmental evaluation of bacterial prints in infectious diseases – study hypothesis

Săndulescu

Florea²,

Streinu‐Cercel

et al. 2014

BMC Infect Dis

View full text Add to dashboard Cite

Expected sensitivity to antibiotics in bacterial infections

Cited by 9 publications

References 0 publications

Recent Advances in Investigation, Prevention, and Management of Healthcare-Associated Infections (HAIs): Resistant Multidrug Strain Colonization and Its Risk Factors in an Intensive Care Unit of a University Hospital

Recent Advances in Investigation, Prevention, and Management of Healthcare-Associated Infections (HAIs): Resistant Multidrug Strain Colonization and Its Risk Factors in an Intensive Care Unit of a University Hospital

Ceftriaxone resistance and adequacy of initial antibiotic therapy in community onset bacterial pneumonia

Bi-compartmental evaluation of bacterial prints in infectious diseases – study hypothesis

Contact Info

Product

Resources

About