2023
DOI: 10.1021/acs.joc.3c01920
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Expedient Synthesis and Characterization of π-Extended Luciferins

Donald R. Caldwell,
Katherine M. Townsend,
Bethany Kolbaba-Kartchner
et al.

Abstract: Bioluminescence imaging enables the sensitive tracking of cell populations and the visualization of biological processes in living systems. Bioluminescent luciferase/luciferin pairs with far-red and near-infrared emission benefit from the reduced competitive absorption by blood and tissue while also facilitating multiplexing strategies. Luciferins with extended π-systems, such as AkaLumine and recently reported CouLuc-1 and -3, can be used for bioluminescence imaging in this long wavelength regime. Existing sy… Show more

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