Expeditious exclusion of acute coronary syndrome diagnosis by combined measurements of copeptin, high-sensitivity troponin, and GRACE score

Diagnostic accuracy of adding copeptin to cardiac troponin for non-ST-elevation myocardial infarction: A systematic review and meta-analysis

“…Myocardial injury triggers neuroendocrine changes that result in the rapid release of copeptin into the circulation [ 29 ]. The measurement of copeptin <6 hours from the presentation of chest pain would make best use of its early release kinetics [ 10 , 30 , 31 ]. In AMI patients, copeptin levels are elevated 0–4 hours after the symptoms occur [ 32 – 34 ].…”

Suspected acute coronary syndrome in the emergency room: Limited added value of heart type fatty acid binding protein point of care or ELISA tests: The FAME-ER (Fatty Acid binding protein in Myocardial infarction Evaluation in the Emergency Room) study

“…a more robust H-FABP assay, or a low hs-cTnT threshold rule-out strategy 23 ) or the addition of a clinical decision rule to admission (dual) biomarker testing. Early discharge of low- to intermediate-risk patients with suspected ACS has recently been reported to be safe, using a strategy incorporating dual biomarker testing on admission (using either H-FABP 24 or copeptin 25,26 along with hs-cTnT) together with clinical risk-stratification. As obviating repeated hs-cTnT testing is likely to shorten length of stay at the ED and to reduce (over)admission of chest pain patients to the hospital for further evaluation, implementation of an ‘early rule out’ strategy should result in substantial reduction of healthcare costs, as costs involved with these patients at the ED are primarily due to admission time.…”

70 Diagnostic Accuracy of Adding Copeptin to Cardiac Troponin for Non-ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis

“…Myocardial injury triggers neuroendocrine changes that result in the rapid release of copeptin into the circulation [29]. The measurement of copeptin <6 hours from the presentation of chest pain would make best use of its early release kinetics [10,30,31]. In AMI patients, copeptin levels are elevated 0-4 hours after the symptoms occur [32][33][34].…”