Experience in primary hepatic neuroendocrine tumor

Jia, Changku; Zhang, Yuanbiao; Xu, Jian; Sun, Ke

doi:10.4318/tjg.2012.0370

Cited by 24 publications

(36 citation statements)

References 20 publications

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“…Primary hepatic NETs characteristically grow slowly and become clinically evident only at an advanced stage [ 8 ]. In most cases, they are incidentally detected, as they are nonfunctional [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…When lymph node and distant metastases are absent, liver resection is adequate for treatment. If lymph node metastasis is present, adjuvant chemotherapy may be needed [ 8 ]. Transarterial chemoembolization or radiotherapy treatments also have been reported as effective treatment modalities [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…If lymph node metastasis is present, adjuvant chemotherapy may be needed [ 8 ]. Transarterial chemoembolization or radiotherapy treatments also have been reported as effective treatment modalities [ 8 ]. Five-year survival and recurrence rates after surgical resection have been reported as 74% and 18%, respectively [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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An Unusual Location of Neuroendocrine Tumour: Primary Hepatic Origin

Ceyran

Artış

Şenol

et al. 2015

Case Reports in Pathology

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Although neuroendocrine tumours (NETs) of primary hepatic origin are extremely rare, most of NETs present with liver metastasis. When a NET is found in the liver, it must be treated to exclude metastasis from extrahepatic primary sites. The patient was a 38-year-old female. Abdominal ultrasound showed an 8 cm tumour in liver during a routine examination. Liver biopsy was done. The tumour was first considered a metastatic hepatic tumour on histopathological examination. No clues to the origin of a primary tumour were found. Upper and lower endoscopy of the GI tract and chest CT were performed to search for a primary tumour and were negative for any tumour. One month later, more extensive areas of the tumour were seen on histopathological examination of second liver biopsy with the same morphologic characteristics as the first biopsy. Immunohistochemically, there was positive staining for synaptophysin, CD 56, and S-100 in the tumour cells. These findings suggested the diagnosis of NET. The diagnosis of primary liver NET was considered in a multidisciplinary meeting. Then, left hepatectomy was performed. The final pathologic diagnosis of the tumour in the resected liver specimen was Grade II NET. The patient was doing well at postoperative 28-month follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An Unusual Location of Neuroendocrine Tumour: Primary Hepatic Origin

Ceyran

Artış

Şenol

et al. 2015

Case Reports in Pathology

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“…In some report, TACE is recommended for cases with unresectable and/or recurrence tumors, but the long-term survival is not usually good enough. Primary surgery integrated with chemotherapy, TACE or even radiotherapy is considered to be an effective modality (Jia et al, 2012). Until the end of our study, 60% of the patients (6/10) had recurrence and 40% patients (4/10) died, including patients with well-differentiated tumors.…”

Section: Treatmentmentioning

confidence: 99%

“…The liver biopsy is the gold standard for preoperative diagnosis and is strongly recommended by some research (Jia et al, 2012), but arguments still occur on the value and risk of it (Skagias et al, 2010); therefore, postoperative pathologic examination is the main method for a final diagnosis. From the histologic point of view the hepatic carcinoma appears as a hemorrhagic, not capsulated mass, with central, irregular fibrosis and hyaline degeneration.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and Therapy of Primary Hepatic Neuroendocrine Carcinoma: Clinical Analysis of 10 Cases

Wang

An²,

Wu³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Primary hepatic neuroendocrine carcinoma (PHNEC) is rarer than extrahepatic gastrointestinal neuroendocrine carcinoma (NEC). It is difficult to make a correct diagnosis and poses a challenge for management. Materials and Methods: Ten PHNEC patients were admitted to our hospital from June 2006 to June 2011. Laboratory tests and imaging scans were performed for diagnosis and exclusion of extrahepatic NEC. All patients were AFP -and CA199-. Seven patients had solid tumors with cystic changes on ultrasonography, CT and/or MRI. For the initial treatment, four patients received combined-therapy and six monotherapy. Considering overall treatment, six patients received combined-therapy and four patients monotherapy. Staging criteria of primary hepatocellular carcinoma (PHC, AJCC 7th edition) were used to differentiate the stage of all patients: 3 patients were stage Ⅰ, 2 stageⅡ, 4 patients stageⅢ and 1 stageⅣ. All patients were followed up and clinical data were gathered. Results: The median follow-up duration was 38.5 months. The 1-year, 2-year, 3-year and 6-year disease-free survival was 80.0%, 46.2% and 46.2% and 0% respectively. The overall survival rates were 100%, 67.1%, 67.1% and 33.6% respectively. Patients in early-stages (Ⅰ/Ⅱ) had similar disease-free and overall survival as those in advanced-stages (Ⅲ/Ⅳ). Patients with monotherapy had significant shorter disease-free and overall survival than the patients with combination-therapy. Conclusions: PHNEC has a unique specificity during its occurrence and development. The staging criteria of PHC might not be suitable for the PHENT. More convenient and effective features need to be found in imaging and laboratory detection. Surgical resection, TACE, chemotherapy and radiofrequency ablation should be performed in combination and actively for patients with PHNEC or recurrence to get the best effectiveness; they might extend the disease-free and overall survival.

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Rare Malignant Liver Tumors

Lü

Fan

et al. 2021

Contrast-Enhanced Ultrasound Imaging of Hepatic Neoplasms

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Experience in primary hepatic neuroendocrine tumor

Cited by 24 publications

References 20 publications

An Unusual Location of Neuroendocrine Tumour: Primary Hepatic Origin

An Unusual Location of Neuroendocrine Tumour: Primary Hepatic Origin

Diagnosis and Therapy of Primary Hepatic Neuroendocrine Carcinoma: Clinical Analysis of 10 Cases

Rare Malignant Liver Tumors

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