The objective: to study the features of systemic and local immunity in pregnant women with a history of sexually transmitted infections.Materials and methods. We examined 100 patients, which were divided into groups: Group I (main) – 50 pregnant women with a history of sexually transmitted infections, with a high risk of placental dysfunction of infectious origin; Group II (control) – 50 pregnant women without obstetric and somatic pathology, who became pregnant spontaneously and had vaginal delivery.In-depth immunological examination included: determination of absolute (×109/л) and relative (%) number of subpopulations of CD3+ lymphocytes (T-lymphocytes), CD4+ (helpers-inductors), CD8+ (cytotoxic suppressors), CD56+ (natural killers), CD19 + (B-lymphocytes); determination of levels of IgG, IgM, IgA in serum and vaginal secretions; studied the content of a number of cytokines (interleukins – IL-1, IL-2, IL-4, IL-10, TNF-α, INFγ) in serum and vaginal contents.Results. The results of studies indicate that in pregnant women with a history of sexually transmitted infections (STIs), that formulate a group of high infectious risk, changes in systemic and local immunity, cytokine status are statistically prognostic. Levels of pro-inflammatory cytokines IL-1, IL-2, TNF-α and anti-inflammatory cytokines IL-4, IL-10 and γ IFN in serum and vaginal contents can be used as prognostic criteria for complications before their clinical manifestations and clinical features of pregnancy. It was also detected that the percentage of СD56+-lymphocytes with properties of natural killers was greater in group of pregnant women with a history of sexually transmitted infections than in the control group dynamically throughout pregnancy (12,3±1,7%, 15,1±1,7%, 13,9±1,73% against 8,6±1,4%, 8,1±1,18%, 7,2±0,98%; р<0,05). Studies also showed a significant increase in IgG levels in pregnant women with a history of sexually transmitted infections compared to the pregnant women in the control group (p <0,05).Conclusion. The study of systemic and local immunity, cytokine status in pregnant women with a history of sexually transmitted infections expands the possibilities of choice of rational, pathogenetic therapy, thereby reducing the incidence of early placental dysfunction of infectious origin, intrauterine infection, obstetric and perinatal complications in these patients.