The paper deals with the actual problem of modern medicine, namely, the analysis of the association of headache (HA) in adolescents with the presence and severity of anxiety compulsive disorders. It presents information on the prevalence, etiology, and clinical manifestations of primary HA in children and adolescents. The characteristics of the components (phobic anxiety and compulsiveness) of the psychoemotional status are given. The authors present the results of their own study showing that frequent episodes of HA are associated with the greater severity of compulsive disorders and phobic anxiety. They highlight approaches to correcting anxiety and preventing its negative impact on the occurrence of HA. The need for further researches in this direction is emphasized.