Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients

Abstract

The results of Sehydrin (Hydrazine Sulfate, HS) treatment of 740 patients with the advanced, recurrent or metastatic solid tumours of various localizations or malignant lymphomas, for whom all the methods of specific treatment (surgery, radiation, chemotherapy) had been exhausted are presented in this work. The objective response, symptomatic therapeutic effects and toxicity were estimated. Clinically significant objective responses were registered in patients with the soft tissue sarcomas, including neuroblastomas, and paradoxically--in such semimalignant tumours as desmoids. Although the objective response in patients with the lung cancer (90%--non-small cell) was only 4%, stabilization of long duration was registered in 22% of cases connected with the impressive relief of heavy common symptoms in 38.5% of the treated patients. Such a subjective response was established in 46.6% of all the 740 cases. The drug given per os was well tolerated by patients in primary and subsequent courses and did not induce myelosuppression or other significant side effects. On the basis of observations available, Sehydrin may be assessed as an alternative drug for the treatment and symptomatic therapy of patients with some advanced solid tumours and malignant lymphomas at a disease stage when the other methods of treatment can not be used. A possible mechanism of antitumour and symptomatic action is being discussed.

Betulin-3,28-diphosphate as a Component of Combination Cytostatic Drugs for the Treatment of Ehrlich Ascites Carcinoma In Vitro and In Vivo Experiments

“…[ 9 , 10 , 11 , 12 ]. Hydrazine sulfate is an insufficiently explored antitumor agent, well-proven in the treatment of tumors of the liver, lungs, mammary glands, intestines, and cervix [ 13 , 14 , 15 ]. The mechanism of HS action includes both the competitive inhibition of monoamine oxidase, leading to the increase of biogenic amines and amino acids (dopamine and serotonin) levels, and the blocking of gluconeogenesis by phosphoenol-pyruvate carboxylase [ 16 ].…”