Conducted the experimental study on the organization of pharmaceutical provision, complaints of patients from the position of management of prescription medicines in Ukraine. It has been proven that the level of organization of pharmaceutical supply affects patient complaints. 750 complaints from patients about unsatisfactory on the organization of the pharmaceutical provision were processed. Found that 77% of complaints of patients (women accounted for 70%; men – 30%) were related to late or incomplete on the organization of the pharmaceutical provision of prescription medicines. Violation of the rights of patients to receive medicines on discounted and free prescriptions of doctors was recorded in 88% of complaints. The matrix of complaints based on patient reports of unsatisfactory of prescription medicines of different clinical and pharmacological, classification and legal and nomenclature and legal groups was constructed. In accordance to the ATC classification, the clinical and pharmacological groups were distributed of medicines on 9 clinical and pharmacological groups. According to ATC code A, 5 INN medicines were not available to patients, and more complaints were received. According to ATC code B, 7 INN medicines were not available to patients, and more complaints were received. According to ATC code C, 25 INN medicines were not available to patients, and more complaints were received. According to ATC code D, 1 INN medicines were not available to patients, and more complaints were received. According to ATC code L, 2 INN medicines were not available to patients, and more complaints were received. According to ATC code M, 1 INN medicines were not available to patients, and more complaints were received. According to ATC code N, 13 INN medicines were not available to patients, and more complaints were received. According to ATC code R, 5 INN medicines were not available to patients, and more complaints were received. According to ATC code S, 2 INN medicines were not available to patients, and more complaints were received. The organization of pharmaceutical provision of these drugs was at a low level. It is substantiated that the main feature of pharmaceutical provision of patients is social orientation. It is proved that it is necessary to actively develop the social potential of health care facilities in the format of transparency, completeness, reliability, and efficiency of information about the costs that form the cost of drugs. In the course of the study, a matrix of complaints based on patient reports of unsatisfactory pharmaceutical provision of drugs of different clinical and pharmacological, classification and legal, nomenclature and legal groups was constructed. On the basis of the matrix of complaints, three national lists of drugs were developed with the further development of organizational and legal measures to increase the level of pharmaceutical provision of patients. It is noted that the reference mechanism of drug pricing is aimed at establishing the level of reimbursement at the expense of the state and reducing costs to 50% for pharmaceutical provision of patients.