Experience of treating Candida auris cases at a general hospital in the state of Qatar

Shaukat, Adila; Ansari, Nasir Al; Wali, Walid Al; Karic, Edin; Madhoun, Ihab El; Mitwally, Hassan; Hamed, Manal; Alutra-Visan, Feah

doi:10.1016/j.idcr.2020.e01007

Cited by 23 publications

(21 citation statements)

References 11 publications

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“…and eight United States isolates reported by Park et al (2019) were completely resistant to VRC. Among the AMB-resistant isolates, five Qatar isolates that were reported by A Shaukat et al (2020) were completely resistant to AMB.…”

Section: Resultsmentioning

confidence: 99%

Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

Zhu

Jiang

et al. 2021

Front. Microbiol.

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IntroductionCandida auris is an emerging multidrug-resistant fungus that may cause infections with a high mortality rate. The first case of C. auris infection was reported in 2009 and infections have been reported in 44 countries. The fungus now represents a major global public health threat. We analyzed cases from the emergence of C. auris infections up until the end of 2020. It is hoped that the results of this analysis will raise awareness in scientists to promote protection and control research pertaining to this pathogen.MethodsPubMed and Web of Science databases were searched for all papers related to C. auris infections up until December 31, 2020. We sorted and organized these data into the following categories: date of publication, patient age and sex, underlying diseases, risk factors for infection, patient mortality information, drug sensitivity information of C. auris isolates, and genetic classification. The χ2 test was used to screen for factors that may affect patient mortality.ResultsA total of 912 patients were included in the analysis. There’s a higher proportion of men and a high proportion of patients were premature babies and elderly people. The proportions of patients with underlying diseases such as diabetes, kidney disease, trauma, and ear disease were also high. More than half of patients had a history of central venous catheter use and a history of broad-spectrum antibiotic use. The χ2 test revealed that only kidney disease (P < 0.05) was an important risk factor for mortality in C. auris-infected patients.ConclusionsA comprehensive understanding of C. auris was achieved following this retrospective analysis, including the characteristics of C. auris-infected patients. In recent years, increasing numbers of multidrug-resistant C. auris isolates have been identified, and the high mortality rates associated with infection merit greater attention from the medical world.

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Section: Resultsmentioning

confidence: 99%

Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

Zhu

Jiang

et al. 2021

Front. Microbiol.

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“…Despite increased awareness, numerous outbreaks have been recently reported from many countries including Arab countries in the Middle East. The first regional case was reported in Kuwait in 2014 [ 11 ], followed by several other reports from the region [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. To our knowledge, this is the first C. auris report from Lebanon.…”

Section: Discussionmentioning

confidence: 99%

“…A possible fifth clade was later identified in Iran [ 10 ]. In the Middle East, the first case was reported in Kuwait in 2014 [ 11 , 12 , 13 ] with subsequent reports from Israel [ 14 ], Oman [ 15 , 16 ], Saudi Arabia [ 17 , 18 ], United Arab Emirates [ 19 ], Iran [ 10 , 20 ], Sudan [ 21 ] and Qatar [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

First Candida auris Outbreak during a COVID-19 Pandemic in a Tertiary-Care Center in Lebanon

et al. 2021

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Candida auris is an emerging fungal pathogen considered as a global health threat. Recently there has been growing concern regarding drug resistance, difficulty in identification, as well as problems with eradication. Although outbreaks have been reported throughout the globe including from several Arab countries, there were no previous reports from Lebanon. We herein report the first cases of C. auris infection from the American University of Beirut Medical Center, a tertiary care center in Lebanon describing the clinical features of the affected patients in addition to the infection control investigation and applied interventions to control the outbreak. Fourteen patients with C. auris infection/colonization identified using MALDI-TOF and VITEK 2- Compact system were reported over a period of 13 weeks. Patients were admitted to four separate critical care units. All of them came through the emergency room and had comorbid conditions. Half of the patients were infected with COVID-19 prior to isolation of the C. auris. C. auris was isolated from blood (two isolates), urine (three isolates), respiratory tract (10 isolates) and skin (one isolate). All the patients had received broad spectrum antibiotics prior to isolation of C. auris. Six patients received antifungal treatment, while the remaining eight patients were considered colonized. Environmental cultures were taken from all four units and failed to isolate the organism from any cultured surfaces. A series of interventions were initiated by the Infection Prevention and Control team to contain the outbreak. Rapid detection and reporting of cases are essential to prevent further hospital transmission. A national standardized infection control registry needs to be established to identify widespread colonization.

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“…Although no mutation was detected in FKS1 , which encodes the subunits of 1,3-beta-D-glucan synthase in the fungal cell wall targeted by the echinocandins [ 29 , 39 ], one isolate was resistant to caspofungin. Several isolates were resistant to at least two classes of antifungals [ 20 ], thus limiting treatment options. One of the limitations in this study was that an antifungal susceptibility test was not performed by a reference method (i.e., Clinical & Laboratory Standards Institute (CLSI) or European Committee on Antimicrobial Susceptibility Testing (EUCAST)).…”

Section: Discussionmentioning

confidence: 99%

“…Candida auris has been reported in the Middle East region including Oman, Saudi Arabia, Iran, the UAE, and Kuwait [ 14 , 15 , 16 , 17 , 18 , 19 ]. Local infections in Qatar have also been reported recently; however, the origin, transmission, and genetic relationships among the isolates were not completely resolved using pulsed-field gel electrophoresis (PFGE) [ 20 ]. The underlying genetic mechanisms conferring resistance have also not been characterized.…”

Section: Introductionmentioning

confidence: 99%

Genomic Epidemiology of Candida auris in Qatar Reveals Hospital Transmission Dynamics and a South Asian Origin

Salah

Sundararaju

Dalil

et al. 2021

JoF

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Candida auris is an emerging, multidrug-resistant fungal pathogen that has become a public health threat with an increasing incidence of infections worldwide. Candida auris spreads easily among patients within and between hospitals. Infections and outbreaks caused by C. auris have been reported in the Middle East region including Oman, Kuwait, Saudi Arabia, and Qatar; however, the origin of these isolates is largely unknown. Pathogen whole genome sequencing (WGS) was used to determine the epidemiology and drug resistance mutations of C. auris in Qatar. Forty-four samples isolated from patients in three hospitals and the hospital environment were sequenced by Illumina NextSeq. Core genome single nucleotide polymorphisms (SNPs) revealed that all isolates belonged to the South Asian lineage with genetic heterogeneity that suggests previous acquisition from foreign healthcare. The genetic variability among the outbreak isolates in the two hospitals (A and B) was low. Four environmental isolates clustered with the related clinical isolates, and epidemiologically linked isolates clustered together, suggesting that the ongoing transmission of C. auris could be linked to infected/colonized patients and the hospital environment. Prominent mutations Y132F and K143R in ERG11 linked to increased fluconazole resistance were detected.

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Experience of treating Candida auris cases at a general hospital in the state of Qatar

Cited by 23 publications

References 11 publications

Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

First Candida auris Outbreak during a COVID-19 Pandemic in a Tertiary-Care Center in Lebanon

Genomic Epidemiology of Candida auris in Qatar Reveals Hospital Transmission Dynamics and a South Asian Origin

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