Experience with a Computer-Based Technique for Estimating Pharmacokinetic Constants from Limited Data

Evaluation of Bayesian Forecasting for Individualized Gentamicin Dosage in Infants Weighing 1000 g or Less

“…-Example of Bayesian forecasting in a 27-weeks' gestation, 900-g infant who was started on gentamicin therapy on day 1. An individualized dosage of 2.6 mg (2.9 mg/kg) every 18 hours resulted in steady-state trough and peak concentrations of 1.8 mg/L and 6.7 mg/L. Computer-fitted line of gentamicin concentration is based on the Bayesian kinetic estimates in Table 1.…”