EXPERIENCE WITH CHLORMETHIAZOLE (HEMINEVRINr̀) IN THE TREATMENT OF TUBERCULOUS ALCOHOLIC PATIENTS

Levendel, L

doi:10.1111/j.1600-0447.1966.tb08827.x

Cited by 3 publications

(2 citation statements)

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“…However, efficient pharmacological treatments for these affected patients are lacking, and is thus an important issue for patients and society . The beneficial effects of adjunctive antidepressant therapy in anti‐TB treatment was noted in the early 1960s, when a low dose of chlormethiazole was described to have an anti‐mycobacterial inhibitory effect . Chlopromazine was then later reported to also have anti‐TB activity in vitro .…”

Section: Association Between Depression and Tbmentioning

confidence: 99%

“…57 The beneficial effects of adjunctive antidepressant therapy in anti-TB treatment was noted in the early 1960s, when a low dose of chlormethiazole was described to have an anti-mycobacterial inhibitory effect. 58 Chlopromazine was then later reported to also have anti-TB activity in vitro. 59 Phenothiazines and thioridazine have also been investigated for their favorable combined antidepressant and anti-TB effects in mice and preclinical studies.…”

Section: Antidepressantsmentioning

confidence: 99%

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The interplay between depression and tuberculosis

Zhang

Wang

et al. 2019

Journal of Leukocyte Biology

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Depression is a major mental health condition and is expected be the most debilitating and widespread health disorder by 2030. Tuberculosis (TB) is also a leading cause of morbidity and mortality worldwide and interestingly, is a common comorbidity of depression. As such, much attention has been paid to the association between these 2 pathologies. Based on clinical reports, the association between TB and depression seems to be bidirectional, with a substantial overlap in symptoms between the 2 conditions. TB infection or reactivation may precipitate depression, likely as a consequence of the host's inflammatory response and/or dysregulation of the hypothalamic–pituitary–adrenal axis. Nevertheless, few studies have considered whether patients with depression are at a higher risk for TB. In this review, we discuss the hypotheses on the association between depression and TB, highlighting the immuno‐inflammatory response and lipid metabolism as potential mechanisms. Improving our understanding of the interplay between these 2 disorders should help guide TB clinical care and prevention both in patients with comorbid depression and in the general population.

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Section: Association Between Depression and Tbmentioning

confidence: 99%